Effects of small concentrations of isoflurane on some psychometric measurements.

Abstract:

:We have investigated the effects of 9.5% and 14.1% MAC concentrations of isoflurane on some psychometric measurements. Both concentrations depressed peak saccadic velocity (P < 0.01), choice reaction time (P < 0.05) and visual analogue scores for sedation (P < 0.05), but not the critical flicker fusion threshold. The incidence of errors in saccade tasks increased in a dose-related fashion, which made analysis of peak saccadic velocity less accurate at more than 10% MAC. The percentage error itself was an indicator of the depth of sedation. All the objective measures correlated highly with the estimated brain tension of isoflurane (r2 = 0.86-0.96), but not the visual analogue score for sedation (r2 = 0.51). This suggests that a combination of peak saccadic velocity, percentage error and choice reaction time is a potentially useful batch of tests to measure recovery from anaesthesia.

journal_name

Br J Anaesth

authors

Yoshizumi J,Marshall RW,Sanders LD,Vickers MD

doi

10.1093/bja/71.6.839

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

839-44

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45598-X

journal_volume

71

pub_type

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