Abstract：
:The analgesic effects and bioavailability of a slow-release preparation of morphine (Duromorph) were studied in 12 patients with acute postoperative pain. Duromorph produced significant analgesia within 1-2 h of administration i.m., and there was a progressive decrease in the mean pain score for at least 8 h. None of the patients requested or received additional analgesia within 12 h, and the incidence of side-effects was similar to that associated with i.m. morphine. During the 8-h study, plasma concentrations of morphine slowly increased for 3 h, and then gradually declined. After 3 h, concentrations were invariably greater than those produced by conventional doses of morphine sulphate i.m. The study confirmed that Duromorph was an effective analgesic with a prolonged duration of action, which was suitable for the management of postoperative pain.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Charway CL,Calvey TN,Williams NE,Murray GRdoi
10.1093/bja/57.10.949subject
Has Abstractpub_date
1985-10-01 00:00:00pages
949-53issue
10eissn
0007-0912issn
1471-6771pii
S0007-0912(17)41261-Xjournal_volume
57pub_type
杂志文章abstract：:We present a case of pulmonary thromboendarterectomy performed successfully in a patient with stomatocytosis. Stomatocytosis is a rare condition of abnormal erythrocyte morphology in which haemolysis and hyperkalaemia occur at cooler temperatures. A 35-yr-old male with stomatocytosis was referred for pulmonary thrombo...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg237
更新日期：2003-11-01 00:00:00
abstract：:The effects of some anaesthetics and other agents used in anaesthetic practice on the neuromuscular blocking activity of cumulative doses of Org NC 45 have been studied in cats anaesthetized with chloralose. As expected from studies with other neuromuscular blocking drugs, both inhalation and i.v. anaesthetics reduced...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.8.785
更新日期：1981-08-01 00:00:00
abstract：:To determine the influence of renal failure on the pharmacokinetics and neuromuscular blockade of Org NC 45 (Norcuron), a new monoquaternary homologue of pancuronium, 13 patients under halothane and nitrous oxide anesthesia were studied. Org NC 45 was administered by 2-min infusion in doses of 0.28 mg kg-1 (normal ren...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.10.1049
更新日期：1981-10-01 00:00:00
abstract：:Local reactions after i.v. injection of diazepam, flunitrazepam and isotonic saline were studied in patients who received extradural analgesia or general anaesthesia. The frequency of thrombophlebitis on the 1st, 3rd and 5th days after the injection of diazepam was 2.1%, 17.0% and 14.9% respectively, after flunitrazep...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/52.8.817
更新日期：1980-08-01 00:00:00
abstract：BACKGROUND:Malposition of tracheostomy tubes is difficult to detect at the bedside and may contribute to eventual device misplacement. Endoscopic examination can be undertaken via tracheoscopic (T-view) or trans-laryngeal (L-view) approach, offering more precise detail regarding positioning within the airway. The aims ...
journal_title：British journal of anaesthesia
pub_type： 评论,信件
doi：10.1093/bja/aew336
更新日期：2017-01-01 00:00:00
abstract：:Integrated electromyographic studies in burned patients, and in normal controls, during the administration of small doses of suxamethonium (0.1 or 0.2 mg kg-1) have shown that the level of paralysis and the duration of paralysis are significantly increased in burn patients and that the effect is greater with larger bu...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.8.1017
更新日期：1987-08-01 00:00:00
abstract：:The influence of sodium nitroprusside (SNP) on mitochondrial respiration was examined in rat liver mitochondria. The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%. A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more mark...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.12.1239
更新日期：1977-12-01 00:00:00
abstract：BACKGROUND:We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS:The two monitors ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aem379
更新日期：2008-03-01 00:00:00
abstract：:Plasma concentrations of pancuronium were measured in nine patients undergoing surgery because of total biliary obstruction. When compared with the averaged model-independent pharmacokinetic parameters obtained for normal patients, the terminal half-life of 270 min was more than twice normal (132 min, P less than 0.00...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.11.1103
更新日期：1977-11-01 00:00:00
abstract：BACKGROUND:A significantly increased risk of acute kidney injury (AKI) with the prophylactic use of aprotinin has been reported in adults undergoing cardiac surgery, but not in children. Blood product transfusions have also been shown to carry an independent risk of AKI. The present study assessed associations between ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aes002
更新日期：2012-05-01 00:00:00
abstract：:The effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure were studied in anaesthetized man. A bolus of either Org NC 45 0.1 mg kg-1 or pancuronium 0.1 mg kg-1 was administered to lightly anaesthetized unstimulated subjects. Following Org NC 45 heart rate decreased in the majority of subject...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/54.4.435
更新日期：1982-04-01 00:00:00
abstract：:Animal studies suggest that alpha 2 agonists inhibit the chemoreceptor response to hypoxia. We have examined the effect of oral clonidine on the ventilatory response to sustained, isocapnic hypoxia (SpO2 79.7% (SD 1.1%) for 20 min) in eight male subjects. The hypoxic ventilatory response was measured before and after ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/76.2.214
更新日期：1996-02-01 00:00:00
abstract：:In 105 patients undergoing day-case surgery recovery of consciousness was significantly faster after enfluane compared with halothane anaesthesia. There was no difference in postoperative morbidity between the two anaesthetic groups. ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/51.12.1143
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND:This study focuses on a recently developed robotic nerve block system and its impact on learning regional anaesthesia skills. We compared success rates, learning curves, performance times, and inter-subject performance variability of robot-assisted vs manual ultrasound (US)-guided nerve block needle guidance...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet440
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aev458
更新日期：2016-02-01 00:00:00
abstract：:Placental transfer of 14C-dimethyltubocurarine (14C-dmtc) was studied during Caesarean section. Liquid scintillation counting was used for determination of 14C activity from the maternal and foetal blood samples. Paper chromatography was used to confirm the stability of 14C-dmtc. In all cases 14C-dmtc was able to cros...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.3.239
更新日期：1976-03-01 00:00:00
abstract：:The choice of an i.v. anaesthetic induction poses problems for the anaesthetist confronted with a patient with one of the acute porphyrias. We undertook a prospective clinical trial in 13 variegate porphyric subjects using propofol as an anaesthetic induction agent. Urinary porphyrin precursors and porphyrins were mea...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/66.1.60
更新日期：1991-01-01 00:00:00
abstract：:Critical narrowing of the dependent airways was examined in anaesthetized dogs with closed chests. Two techniques were used, (a) "closing" volume (CV), measured from the expired nitrogen plateau and (b) tantalum bronchography, to measure the calibre of airways of 3-8 mm diameter in the upper (UZ), middle (MZ) and lowe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.8.735
更新日期：1978-08-01 00:00:00
abstract：:The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in thre...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.4.345
更新日期：1978-04-01 00:00:00
abstract：:The metabolic effect of infusing 1.0-1.5 litre of Hartmann's solution to normal subjects and those with maturity onset diabetes has been studied during surgery. It was found that the use of Hartmann's solution after operation was associated with a 7.5 mmol litre-u increase in plasm glucose concentration compared with ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.2.185
更新日期：1978-02-01 00:00:00
abstract：BACKGROUND:Target-controlled infusion (TCI) systems use pharmacokinetic (PK) models to predict the drug infusion rates necessary to achieve a desired target plasma or effect-site concentration. As new PK models are developed and implemented in TCI systems, there can be uncertainty as to which target concentrations are ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.05.051
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS:PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1016/j.bja.2020.10.022
更新日期：2021-02-01 00:00:00
abstract：:The effect of alfentanil on sympathetic reflexes evoked by supramaximal electrical stimulation of the radial nerve has been observed in five dogs anaesthetized with alpha-chloralose, paralysed with suxamethonium and artificially ventilated. In five dogs during the infusion of alfentanil at a rate of 20 micrograms kg-1...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/61.4.441
更新日期：1988-10-01 00:00:00
abstract：:We have studied the cardiovascular effects of equipotent concentrations of halothane or isoflurane, with or without 50% nitrous oxide in oxygen, in 80 patients, aged 60 yr or more, during 20 min of stable equipotent anaesthesia. Non-invasive measurement techniques were used, with suprasternal Doppler ultrasonography f...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/80.2.169
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:The safety of performing spinal anaesthesia for both patients and anaesthetists alike in the presence of active infection with the novel coronavirus disease 2019 (COVID-19) is unclear. Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.03.007
更新日期：2020-06-01 00:00:00
abstract：Background.:Perioperative administration of cefazolin reduces the incidence of perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 and 5 h after the initial dose. This study was undertaken to determine whether intraoperative continuous infusions of cefazolin achieve better probab...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aex026
更新日期：2017-06-01 00:00:00
abstract：:Arterial PO2 (PaO2) has been related to inspired oxygen concentration (FIO2 range 0.21-0.60) in 20 patients, breathing spontaneously, while recovering from a range of conditions treated in an intensive therapy unit. There was a highly significant linear trend (P < 0.001) for the mean venous admixture ("virtual shunt")...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/72.5.515
更新日期：1994-05-01 00:00:00
abstract：:Dose-duration relationships for vecuronium were determined and the duration of action produced by vecuronium 0.3 mg kg-1 shown to equal that of pancuronium 0.1 mg kg-1. Using these doses, the neuromuscular blocking properties and cardiovascular effects of the two drugs were compared. With large dose administration of ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/61.2.180
更新日期：1988-08-01 00:00:00
abstract：:Sickle cell disease is a congenital haemoglobinopathy with a high incidence of perioperative complications. Traditional anaesthetic management, based largely on extrapolation from biochemical models, has emphasized avoidance of red cell sickling to prevent exacerbations of the disease. This historical review outlines ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aei129
更新日期：2005-09-01 00:00:00
abstract：:Recent research has shown that high-frequency, gamma-band electroencephalographic (EEG) oscillations (40-60 Hz) may be an important marker of the conscious state. We compared the ability of the bispectral index (BIS) to distinguish the awake and anaesthetized states during the induction of general anaesthesia with: (i...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/86.1.50
更新日期：2001-01-01 00:00:00
