Ondansetron and droperidol in the prevention of postoperative nausea and vomiting.

Abstract:

:We have performed a prospective, randomized, double-blind clinical study to assess the efficacy of ondansetron, droperidol, or both, in preventing postoperative emesis. We studied 242 patients undergoing biliary or gynaecological surgery under general anaesthesia. Shortly before induction of anaesthesia, patients received: saline i.v. (group I, n = 62); droperidol 2.5 mg i.v. (group 2, n = 60); ondansetron 4 mg i.v. (group 3, n = 57); or droperidol 2.5 mg with ondansetron 4 mg i.v. (group 4, n = 63). Nausea occurred in 45%, 37%, 32% and 29% (P = 0.234) and vomiting in 23%, 17%, 9% and 5% (P = 0.016) of patients in groups 1, 2, 3 and 4, respectively, during the first 24 h. Groups 2 and 4 had greater sedation scores than group 1 during the first 3 h (P < 0.01). We conclude that both droperidol and ondansetron showed a significant antiemetic effect, ondansetron was not significantly better than droperidol, and the combination of droperidol and ondansetron was better than droperidol but no better than ondansetron alone.

journal_name

Br J Anaesth

authors

Bugedo G,Gonzalez J,Asenjo C,De la Cuadra JC,Gajardo A,Castillo L,Muñoz H,Dagnino J

doi

10.1093/bja/83.5.813

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

813-4

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)38279-X

journal_volume

83

pub_type

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