Blood propofol concentration and psychomotor effects on driving skills.

abstract：:We describe a six-compartment physiological model of the kinetics and dynamics of induction of anaesthesia with propofol in sheep. It includes a faithful description of initial bolus kinetics caused by accurate representations of the inter-relationships between initial vascular mixing, lung kinetics and cardiac output...

journal_title：British journal of anaesthesia

authors： Upton RN,Ludbrook GL

更新日期：1997-10-01 00:00:00

abstract：Background:Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. We therefore conducted...

journal_title：British journal of anaesthesia

authors： Nieuwenhuijs-Moeke GJ,Nieuwenhuijs VB,Seelen MAJ,Berger SP,van den Heuvel MC,Burgerhof JGM,Ottens PJ,Ploeg RJ,Leuvenink HGD,Struys MMRF

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-co...

journal_title：British journal of anaesthesia

authors： Lee JR,Jung CW,Lee YH

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Prediction models to identify parturients who experience protracted pain, prolonged opioid use, and delayed self-assessed functional recovery are currently inadequate. METHODS:For this study, 213 nulliparous women who planned vaginal delivery were enrolled and assessed daily until they completed three outco...

journal_title：British journal of anaesthesia

authors： Komatsu R,Carvalho B,Flood P

更新日期：2018-08-01 00:00:00

abstract：:Raised intracranial pressure (ICP) and low cerebral blood flow (CBF) are associated with ischaemia and poor outcome after brain injury. Therefore, many management protocols target these parameters. This overview summarizes the technical aspects of ICP and CBF monitoring, and their role in the clinical management of br...

journal_title：British journal of anaesthesia

authors： Steiner LA,Andrews PJ

更新日期：2006-07-01 00:00:00

abstract：:The haemodynamic effects of diltiazem were studied in six dogs during fentanyl-nitrous oxide (in oxygen) anaesthesia. A bolus of diltiazem 300 micrograms kg-1 was given, followed by infusions at 30, 60 and 90 micrograms kg-1 min-1 which produced plasma diltiazem concentrations of 392 +/- 30, 908 +/- 54 and 1483 +/- 13...

journal_title：British journal of anaesthesia

authors： Griffin RM,Dimich I,Jurado R,Kaplan JA

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:There has been increasing use of invasive techniques, such as extracorporeal organ support, in intensive care units (ICU), and declining autopsy rates. Thus, new measures are needed to maintain high-quality standards. We investigated the potential of computed tomography (CT)-based virtual autopsy to substitu...

journal_title：British journal of anaesthesia

authors： Wichmann D,Heinemann A,Zähler S,Vogel H,Höpker W,Püschel K,Kluge S

更新日期：2018-06-01 00:00:00

abstract：:The effect of incubation at 37 degrees C, 46 degrees C, 47 degrees C and 48 degrees C for 1 h on the osmotic fragility of blood was determined. Blood taken from volunteers into ACD and CPD was examined after 1, 7, 14 and 21 days of storage. In addition, 22-day-old blood stored in CPD was examined. The osmotic fragilit...

journal_title：British journal of anaesthesia

authors： Van der Walt JH,Russell WJ

更新日期：1978-08-01 00:00:00

abstract：:Thiopental is a racemate of equimolar R- and S-thiopental enantiomers that have different potencies in laboratory experiments. We measured concentrations of R- and S-thiopental in plasma, tissues and brain microdialysate of rats after computer-controlled infusion of thiopental i.v. to a plasma concentration of 40 micr...

journal_title：British journal of anaesthesia

authors： Mather LE,Edwards SR,Duke CC,Cousins MJ

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Anaesthetics suppress the formation of lasting memories at concentrations that do not suppress perception, but it is unclear which elements of the complex cascade leading from a conscious experience to a lasting memory trace are disrupted. Experiments in conscious humans suggest that subhypnotic concentratio...

journal_title：British journal of anaesthesia

authors： Pearce RA,Duscher P,Van Dyke K,Lee M,Andrei AC,Perouansky M

更新日期：2012-04-01 00:00:00

abstract：Background.:Compromised tissue oxygenation is one of the root causes of dysfunction of various organs and postoperative complications. Oxygenation of different tissue beds may follow different patterns of change during physiological derangement. Methods.:Patients undergoing elective major posterior spine surgery parti...

journal_title：British journal of anaesthesia

authors： Meng L,Xiao J,Gudelunas K,Yu Z,Zhong Z,Hu X

更新日期：2017-04-01 00:00:00

abstract：:Seven patients are described in whom a prophylactic blood patch was instituted within 15 min of accidental dural puncture. Five of the patients received extradural anaesthesia before the blood patch, and one after the blood patch had been performed. In three of these patients further "top-up" doses of local anaestheti...

journal_title：British journal of anaesthesia

authors： Quaynor H,Corbey M

更新日期：1985-05-01 00:00:00

abstract：:Progressive obstruction of an axillary vein following an axillary approach to brachial plexus blockade is described. At surgical exploration, the axillary vein was narrowed with an aneurysm of its wall. It is likely that, during the performance of the block, the needle penetrated the adventitia of the vein, causing a ...

journal_title：British journal of anaesthesia

authors： Restelli L,Pinciroli D,Conoscente F,Cammelli F

更新日期：1984-09-01 00:00:00

abstract：:We have studied the effect of clonidine, dexmedetomidine and morphine on gastric emptying and gastrointestinal transit in the rat. In one group, each agonist was injected i.p. in 6-12 male Wistar rats. In another group of rats, yohimbine, naloxone or saline was injected with an agonist. At 30 min, radiolabelled saline...

journal_title：British journal of anaesthesia

authors： Asai T,Mapleson WW,Power I

更新日期：1997-03-01 00:00:00

abstract：:We report the case of a morbidly obese patient who developed rhabdomyolysis with acute renal failure, hepatic dysfunction, and an increase of cardiac troponin-1 after total knee arthroplasty. Postoperative rhabdomyolysis has a wide range of triggers and differential diagnoses that should be considered by the anaesthes...

journal_title：British journal of anaesthesia

authors： Karcher C,Dieterich HJ,Schroeder TH

更新日期：2006-12-01 00:00:00

abstract：:We have studied the relationship between gas exchange and mechanical frequency response during high frequency jet ventilation (HFJV) at 0.5-5.0 Hz in anaesthetized pigs. The mechanical gain curve showed a minimal "anti-resonant" response at 0.8 Hz (f1) and a maximal "resonant" response at 5.0 Hz (f2). This finding may...

journal_title：British journal of anaesthesia

authors： Lin ES,Jones MJ,Mottram SD,Smith BE,Smith G

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after major surgery. We hypothesized that intraoperative GDT would reduce the...

journal_title：British journal of anaesthesia

authors： Challand C,Struthers R,Sneyd JR,Erasmus PD,Mellor N,Hosie KB,Minto G

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:We previously demonstrated that i.v. emulsified isoflurane induces general anaesthesia in animals. In this study, we compared the pharmacokinetics of emulsified isoflurane given as i.v. bolus and as infusion in beagle dogs. METHODS:Sixteen beagle dogs were assigned randomly to a bolus group comprising three...

journal_title：British journal of anaesthesia

authors： Yang XL,Zhang WS,Liu J,Yang ZB,Jiang XH

更新日期：2013-01-01 00:00:00

abstract：:This editorial looks at some of the various anesthesias used during pregnancy termination. Trichloroethylene, often a popular substitute for halothane, has been subjected to little evaluation. Only clinical study however, can actually establish the significance of myometrial depressant properties in the pregnant pat...

journal_title：British journal of anaesthesia

authors： Grant IS

更新日期：1980-08-01 00:00:00

abstract：:Anaesthetic and sedative drugs transiently disrupt normal neural activity to facilitate healthcare procedures in children, but they can also cause long-term brain injury in experimental animal models. The US Food and Drug Administration (FDA) has recently advised that repeated or lengthy exposures to anaesthetic and s...

journal_title：British journal of anaesthesia

authors： O'Leary JD,Warner DO

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The minimum effective volume of local anaesthetic needed to provide effective analgesia of the four main branches of the axillary brachial plexus is unknown. This study was performed to determine the minimum volume of local anaesthetic required to surround the nerves of the axillary brachial plexus and docum...

journal_title：British journal of anaesthesia

authors： Harper GK,Stafford MA,Hill DA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Current guidelines for perioperative management of coronavirus disease 19 (COVID-19) are mainly based on extrapolated evidence or expert opinion. We aimed to systematically investigate how COVID-19 affects perioperative management and clinical outcomes, to develop evidence-based guidelines. METHODS:First, w...

journal_title：British journal of anaesthesia

authors： Zheng H,Hébert HL,Chatziperi A,Meng W,Smith BH,Yan J,Zhou Z,Zhang X,Luo A,Wang L,Zhu W,Hu J,Colvin LA

更新日期：2020-12-01 00:00:00

abstract：:A specific technique for detection of pulmonary aspiration during the perioperative period is lacking. In this study, we developed a scintigraphic method for its diagnosis. Technetium 99m sulphur colloid was given orally 2 h before an i.v. infusion of propofol in patients undergoing elective colonoscopy. During the pr...

journal_title：British journal of anaesthesia

authors： Rezaiguia-Delclaux S,Streich B,Bouleau D,Delchier JC,Dhonneur G,Meignan M,Duvaldestin P

更新日期：2001-08-01 00:00:00

abstract：:Metoclopramide hastens emptying of the stomach. Since it may be given to patients before operation, the sedative and toxic effects of 10- and 20-mg does given i.m. were studied in patients and student volunteers. Saline and diazepam 10 mg were used as placebo and reference drugs. Neither dose of metoclopramide had as ...

journal_title：British journal of anaesthesia

authors： Dundee JW,Clarke RS,Howard PJ

更新日期：1974-07-01 00:00:00

abstract：:One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endoscopy. Sedation and conditions for examination were comparable and satisfactory in both groups. Midazolam produced more amnesia ...

journal_title：British journal of anaesthesia

authors： Magni VC,Frost RA,Leung JW,Cotton PB

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam. METHODS:After ethics committee approval and consent, 40 adult patients undergoing s...

journal_title：British journal of anaesthesia

authors： Bulach R,Myles PS,Russnak M

更新日期：2005-03-01 00:00:00

abstract：:Three formulations of etomidate were evaluated in unpremedicated patients undergoing minor gynaecological procedures. There was a high frequency of pain on injection (up to 50%) and excitatory phenomena (up to 95%) with all formulations. The frequency of excitatory phenomena was significantly greater than that after m...

journal_title：British journal of anaesthesia

authors： Zacharias M,Clarke RS,Dundee JW,Johnston SB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models. METHODS:Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice w...

journal_title：British journal of anaesthesia

authors： Marcil J,Walczak JS,Guindon J,Ngoc AH,Lu S,Beaulieu P

更新日期：2006-06-01 00:00:00

abstract：:The results of the ventilatory management of babies, obtained in the first 3 years of a neonatal surgical intensive care unit, are assessed. Overall mortality figures and detailed examination of the cause of death in individual diagnostic groups support a selective approach to intermittent positive pressure ventilatio...

journal_title：British journal of anaesthesia

authors： Mackersie AM,Hatch DJ,Farnsworth GM

更新日期：1980-03-01 00:00:00

abstract：:We have studied haemodynamic responses to 0, 0.25, 0.5, 0.75 and 1 MAC isoflurane administration in 10 patients during a zero-order propofol infusion and normocapnia. Isoflurane reduced mean arterial pressure (MAP), systemic vascular resistance and left ventricular stroke work in a dose-dependent manner (29%, 38% and ...

journal_title：British journal of anaesthesia

authors： Verborgh C,Verbessem D,Camu F

更新日期：1992-07-01 00:00:00