Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group.

Abstract:

:Neurone specific enolase (NSE) and S-100 beta protein have been used as markers of brain damage. We hypothesized that blood concentrations of NSE and S-100 beta protein reflect cognitive dysfunction after abdominal surgery. We studied 65 elderly patients in whom neuropsychological testing was performed before abdominal surgery, at discharge from hospital and after 3 months. Serum concentrations of NSE and S-100 beta protein were measured before surgery and after 24, 48 and 72 h. Serum concentrations of S-100 beta protein increased significantly while NSE concentrations decreased significantly. The increase in S-100 beta protein concentration after 48 h was significantly greater in patients with delirium. No correlation was found between cognitive dysfunction and S-100 beta protein or NSE concentration. We conclude that blood concentrations of S-100 beta protein increase after abdominal surgery and may be related to postoperative delirium.

journal_name

Br J Anaesth

authors

Rasmussen LS,Christiansen M,Rasmussen H,Kristensen PA,Moller JT

doi

10.1093/oxfordjournals.bja.a013410

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

242-4

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)38125-4

journal_volume

84

pub_type

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