Blood concentrations of nitrous oxide in theatre personnel.

abstract：:The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful preme...

journal_title：British journal of anaesthesia

authors： Kanto J,Sjövall S,Vuori A

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS:The two monitors ...

journal_title：British journal of anaesthesia

authors： Dahaba AA,Bornemann H,Holst B,Wilfinger G,Metzler H

更新日期：2008-03-01 00:00:00

abstract：:In 10 dogs, one carotid sinus was isolated from the systemic circulation without disturbing its sympathetic innervation. The isolated sinus was connected to a servo-controlled pressure generator which kept mean intrasinus pressure, pulse pressure, and frequency of pulsation constant. The carotid sinus baroreceptor ner...

journal_title：British journal of anaesthesia

authors： Behnia R,Koushanpour E,Shanks CA,McCarthy WJ

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

journal_title：British journal of anaesthesia

authors： Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

更新日期：2015-03-01 00:00:00

abstract：:Muscle biopsy and in vitro contracture tests for diagnosis of susceptibility to malignant hyperthermia (MH) were performed in two patients who had developed fever and severe myolysis during exercise. MH susceptibility was confirmed in one patient, but in the other, exercise-induced heat stroke proved to be the correct...

journal_title：British journal of anaesthesia

authors： Hackl W,Winkler M,Mauritz W,Sporn P,Steinbereithner K

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Ketamine-induced neuroapoptosis has been attributed to diverse stress-related mechanisms. Glycogen synthase kinase-3β (GSK-3β) is a multifunctional kinase that is active in neuronal development and linked to neurodegenerative disorders. We hypothesized that ketamine would enhance GSK-3β-induced neuroapopotos...

journal_title：British journal of anaesthesia

authors： Liu JR,Baek C,Han XH,Shoureshi P,Soriano SG

更新日期：2013-06-01 00:00:00

abstract：:We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent manner with an ED50 value of 140 (95% confidence limits 123-160) mg kg-1 (n = 40; eight animals per d...

journal_title：British journal of anaesthesia

authors： Irifune M,Sugimura M,Takarada T,Maeoka K,Shimizu Y,Dohi T,Nishikawa T,Kawahara M

更新日期：1999-10-01 00:00:00

abstract：:In order to clarify the relative contribution of hepatic metabolism to the short term disposition of methohexitone, we have measured hepatic blood flow during induction of anaesthesia with a 1.5-mg kg-1 i.v. bolus dose of methohexitone. Median hepatic clearance was 1.01 litre min-1 and hepatic extraction 87%. As a con...

journal_title：British journal of anaesthesia

authors： Lange H,Stephan H,Brand C,Zielmann S,Sonntag H

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:General anaesthesia is a balance between hypnosis and analgesia. We investigated whether an increase in remifentanil blood concentration would reduce the amount of propofol required to maintain a comparable level of anaesthesia in 60 patients undergoing ambulatory surgery. METHODS:Patients were allocated ra...

journal_title：British journal of anaesthesia

authors： Milne SE,Kenny GN,Schraag S

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Several medications have proved to be useful in preventing postoperative nausea and vomiting (PONV). However, routine antiemetic prophylaxis is not cost-effective. We evaluated the accuracy and discriminating power of an artificial neural network (ANN) to predict PONV. METHODS:We analysed data from 1086 in-...

journal_title：British journal of anaesthesia

authors： Peng SY,Wu KC,Wang JJ,Chuang JH,Peng SK,Lai YH

更新日期：2007-01-01 00:00:00

abstract：:We have investigated 296 inpatients in a single-blind observer study to determine the incidence, degree and duration of hypoxaemia during anaesthesia. The clinical recognition of hypoxaemia, period of time until recognition and risk factors were studied. Oxygen saturation (Spo2) was monitored continuously with a pulse...

journal_title：British journal of anaesthesia

authors： Moller JT,Johannessen NW,Berg H,Espersen K,Larsen LE

更新日期：1991-04-01 00:00:00

abstract：:Cardiovascular risk prediction using clinical risk factors is integral to both the European and the American algorithms for preoperative cardiac risk assessment and perioperative management for non-cardiac surgery. We have reviewed these risk factors and their ability to guide clinical decision making. We examine thei...

journal_title：British journal of anaesthesia

authors： Biccard BM,Rodseth RN

更新日期：2011-08-01 00:00:00

abstract：:A series of 443 spinal anaesthetics is described. The procedures included operative vaginal delivery, removal of retained placenta and a miscellaneous group common to most obstetric units. Failure to provide effective relief of pain occurred in 5.2% of patients. There was one potentially serious complication, but with...

journal_title：British journal of anaesthesia

authors： Crawford JS

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:The efficacy of opioids typically decreases after long-term use owing to the development of tolerance. Glial activation and the upregulation of proinflammatory cytokines are related to the induction of tolerance. We investigated the effect of leukemia inhibitory factor (LIF) on morphine analgesia and toleran...

journal_title：British journal of anaesthesia

authors： Tu HJ,Kang KH,Ho SY,Liou HC,Liou HH,Lin CP,Fu WM

更新日期：2016-10-01 00:00:00

abstract：:Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 micrograms kg-1 min-1 (0.8-1.5 micrograms kg-1 min-1), being in the same range ...

journal_title：British journal of anaesthesia

authors： de Vries JW,Ros HH,Booij LH

更新日期：1986-10-01 00:00:00

abstract：:We have assessed neuromuscular block electromyographically at the gastrocnemius muscle and compared it with that at the abductor digiti minimi muscle in 60 adult patients undergoing cervical spine surgery under general anaesthesia. All patients were in the prone position. After vecuronium 0.2 mg kg-1, times to onset o...

journal_title：British journal of anaesthesia

authors： Saitoh Y,Narumi Y,Fujii Y,Ueki M,Makita K

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:There are no published data to predict tracheostomy tube size as growth proceeds in children requiring long-term ventilation. METHODS:A retrospective audit was undertaken of children having long-term ventilation, managed from the Southport spinal injuries unit. The dates of step-up in size of tracheostomy t...

journal_title：British journal of anaesthesia

authors： Behl S,Watt JW

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The observation that patients presenting for bariatric surgery had a high incidence of neuromuscular blocking agent (NMBA) anaphylaxis prompted this restricted case-control study to test the hypothesis that obesity is a risk factor for NMBA anaphylaxis, independent of differences in pholcodine consumption. ...

journal_title：British journal of anaesthesia

authors： Sadleir PHM,Clarke RC,Goddard CE,Day C,Weightman W,Middleditch A,Platt PR

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:A pulmonary hypertensive crisis (PHC) can be a life-threatening condition. We established a PHC model by exposing rats with monocrotaline (MCT)-induced pulmonary hypertension to acute hypoxia, and investigated the effects of vasopressin, phenylephrine, and norepinephrine on the PHC. METHODS:Four weeks after...

journal_title：British journal of anaesthesia

authors： Sugawara Y,Mizuno Y,Oku S,Goto T

更新日期：2019-04-01 00:00:00

abstract：:A computer program written mainly in a high level language (ALGOL), but with the sampling routine and certain calculations written in assembly language (SIR), has been developed to assess neuromuscular blockade in anaesthetized man by means of an Elliott 903 digital computer. The program allows the on-line real-time a...

journal_title：British journal of anaesthesia

authors： Perry IR,Worsley R,Sugai N,Payne JP

更新日期：1975-10-01 00:00:00

abstract：Background.:Perioperative administration of cefazolin reduces the incidence of perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 and 5 h after the initial dose. This study was undertaken to determine whether intraoperative continuous infusions of cefazolin achieve better probab...

journal_title：British journal of anaesthesia

authors： Naik BI,Roger C,Ikeda K,Todorovic MS,Wallis SC,Lipman J,Roberts JA

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Paradoxical excitement response during sedation consists of loss of affective control and abnormal movements. Chronic alcohol abuse has been proposed as a predisposing factor despite lack of supporting evidence. Because alcohol and propofol have a common site of action, we postulated that paradoxical excitem...

journal_title：British journal of anaesthesia

authors： Jeong S,Lee HG,Kim WM,Jeong CW,Lee SH,Yoon MH,Choi JI

更新日期：2011-12-01 00:00:00

abstract：:We have studied the effects of stepwise increasing infusion rates of propofol 200-500 micrograms kg-1 min-1 on blood concentrations of propofol and the disposition and clearance of a bolus dose of indocyanine green (ICG) 0.5 mg kg-1 in 10 acutely instrumented dogs. Drug concentrations and ICG clearance were measured 3...

journal_title：British journal of anaesthesia

authors： Sear JW,Diedericks J,Foex P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explore difficulties at work from anaesthetists' own perspective and to examine how anaesthetists handle and cope with situations that are perceived as difficult and potentially stressful. METHODS:Two sets of interviews were conducted with 19 specialist anaesthetists in Sweden. ...

journal_title：British journal of anaesthesia

authors： Larsson J,Rosenqvist U,Holmström I

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Risks and costs of allogeneic blood transfusions mandate strategies to reduce blood loss in surgery. The objective of this study was to assess the efficacy of antifibrinolytic treatment in reducing perioperative blood loss during total knee replacement. METHODS:A double-blind, randomized and placebo-control...

journal_title：British journal of anaesthesia

authors： Camarasa MA,Ollé G,Serra-Prat M,Martín A,Sánchez M,Ricós P,Pérez A,Opisso L

更新日期：2006-05-01 00:00:00

abstract：:We have studied the pharmacokinetics and pharmacodynamics of alfentanil, fentanyl and sufentanil together with propofol in patients undergoing coronary artery bypass graft surgery (CABG). Sixty patients (age 40-73 yr, 56 male) were assigned randomly to receive alfentanil, fentanyl or sufentanil and propofol. Plasma co...

journal_title：British journal of anaesthesia

authors： Ahonen J,Olkkola KT,Hynynen M,Seppälä T,Ikävalko H,Remmerie B,Salmenperä M

更新日期：2000-10-01 00:00:00

abstract：:The effect of ketamine analgesia on gastric emptying was assessed in five healthy volunteers. Gastric emptying, estimated indirectly by the absorption of orally administered paracetamol, was not significantly delayed following administration of i.m. ketamine when compared with placebo. ...

journal_title：British journal of anaesthesia

authors： Grant IS,Nimmo WS,Clements JA

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Psychological factors are thought to drive inter-patient variations in anaesthetic and analgesic requirements. This cross-sectional study investigated whether preoperative psychological factors can predict anaesthetic requirements and postoperative pain. METHODS:Before total thyroidectomy, 100 consecutive w...

journal_title：British journal of anaesthesia

authors： Kil HK,Kim WO,Chung WY,Kim GH,Seo H,Hong JY

更新日期：2012-01-01 00:00:00

abstract：:Protein kinase C (PKC) is a key regulatory enzyme that has been implicated as a molecular target for the action of general anaesthetics. We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol...

journal_title：British journal of anaesthesia

authors： Hemmings HC Jr,Adamo AI

更新日期：1997-02-01 00:00:00

abstract：:The effects of diazepam, which acts at GABAA receptors to enhance the effects of GABA, and ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, on local rates of cerebral glucose utilization (ICMRglc) were examined in unrestrained rats. Four groups were studied: vehicle-injected controls; and ketamine...

journal_title：British journal of anaesthesia

authors： Eintrei C,Sokoloff L,Smith CB

更新日期：1999-04-01 00:00:00