Hepatic disposition of methohexitone in patients undergoing coronary bypass surgery.

Abstract:

:In order to clarify the relative contribution of hepatic metabolism to the short term disposition of methohexitone, we have measured hepatic blood flow during induction of anaesthesia with a 1.5-mg kg-1 i.v. bolus dose of methohexitone. Median hepatic clearance was 1.01 litre min-1 and hepatic extraction 87%. As a consequence of the high hepatic extraction, the hepatic clearance of methohexitone was closely dependent on hepatic plasma flow.

journal_name

Br J Anaesth

authors

Lange H,Stephan H,Brand C,Zielmann S,Sonntag H

doi

10.1093/bja/69.5.478

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

478-81

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46026-0

journal_volume

69

pub_type

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