A new method for measurement of anaesthetic partial pressure in blood.

Abstract:

:We have developed a simple, reliable method for rapid analysis of the partial pressure of volatile anaesthetic agents, based on a two-stage, head-space analysis. It is designed to solve the problems associated with reduced solubility of modern anaesthetics. After equilibration and analysis of a 2-ml sample of blood at 37 degrees C, 1 ml is transferred to another vial for a second equilibration. This ensures that there is no vapour in the headspace before the second equilibration. Measurements were performed on human blood samples equilibrated with 1% sevoflurane, 2.5% isoflurane or 3% desflurane in a tonometer. The mean error in the sample measurements was -2.3% of the tonometer reading and the 95% confidence interval for an individual measurement was +/- 8.5%. Blood samples may be stored overnight without any significant change in the results.

journal_name

Br J Anaesth

authors

Smith MA,Sapsed-Byrne SM,Lockwood GG

doi

10.1093/bja/78.4.449

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

449-52

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)41918-0

journal_volume

78

pub_type

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