Lung protective strategies in anaesthesia.

abstract：:We compared psychomotor recovery after total intravenous anaesthesia (TIVA) with remifentanil/propofol and balanced anaesthesia (BAL) with etomidate/fentanyl/isoflurane in 40 patients, ASA I-III, aged > or =80 yr undergoing elective cataract surgery. Recovery times were recorded and psychomotor recovery was assessed a...

journal_title：British journal of anaesthesia

authors： Kubitz J,Epple J,Bach A,Motsch J,Martin E,Schmidt H

更新日期：2001-02-01 00:00:00

abstract：:The relative sensitivity of sympathetic preganglionic and postganglionic axons, B and C fibres, respectively, to two structurally dissimilar local anaesthetics was examined. The concentration of amethocaine (ester-linked tertiary amine) or prilocaine (amide-linked secondary amine) required to reduce the B fibre compou...

journal_title：British journal of anaesthesia

authors： Scurlock JE,Heavner JE,de Jong RH

更新日期：1975-11-01 00:00:00

abstract：:We have studied the effects of stepwise increasing infusion rates of propofol 200-500 micrograms kg-1 min-1 on blood concentrations of propofol and the disposition and clearance of a bolus dose of indocyanine green (ICG) 0.5 mg kg-1 in 10 acutely instrumented dogs. Drug concentrations and ICG clearance were measured 3...

journal_title：British journal of anaesthesia

authors： Sear JW,Diedericks J,Foex P

更新日期：1994-04-01 00:00:00

abstract：:The accuracy of five new oxygen and nitrous oxide flowmeter units was investigated using the bubble meter method. The results were compared with those previously found in flowmeters withdrawn from clinical use. New oxygen flowmeters demonstrated less inaccuracies than old flowmeters. No differences were found between ...

journal_title：British journal of anaesthesia

authors： Waaben J,Brinkløv MM,Stokke DB

更新日期：1980-01-01 00:00:00

abstract：:The determination of blood flow, i.e. cardiac output, is an integral part of haemodynamic monitoring. This is a review on noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. We present the underlying principles and validation data of the following technologies: thoracic elect...

journal_title：British journal of anaesthesia

authors： Saugel B,Cecconi M,Wagner JY,Reuter DA

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The inhibitory effect of anaesthetic agents on hypoxic pulmonary vasoconstriction may depend upon their dose, especially when using a volatile agent. The aim of this randomized open study was to compare the effects of sevoflurane and propofol, as primary anaesthetic agents, on oxygenation during one-lung ven...

journal_title：British journal of anaesthesia

authors： Pruszkowski O,Dalibon N,Moutafis M,Jugan E,Law-Koune JD,Laloë PA,Fischler M

更新日期：2007-04-01 00:00:00

abstract：:Fresh gas flows of nitrous oxide, oxygen and halothane at 6, 3, 2 and 1 litre/min were introduced into a circle absorber system. Spontaneous respiration and IPPV were studied and a regression of inspired on delivered oxygen concentration % was calculated. The difference between delivered and inspired oxygen concentrat...

journal_title：British journal of anaesthesia

authors： Raymond JA

更新日期：1976-03-01 00:00:00

abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...

journal_title：British journal of anaesthesia

authors： Clarke TN,Foëx P,Roberts JG,Saner CA,Bennett MJ

更新日期：1980-03-01 00:00:00

abstract：:We studied psychomotor performance in 10 healthy volunteers during recovery after a target-controlled infusion of propofol. Choice reaction time, dual task tracking with secondary reaction time and a within-list recognition task were assessed at target blood propofol concentrations of 0.8, 0.4 and 0.2 microgram ml-1. ...

journal_title：British journal of anaesthesia

authors： Grant SA,Murdoch J,Millar K,Kenny GN

更新日期：2000-09-01 00:00:00

abstract：:Protein kinase C (PKC) is a key regulatory enzyme that has been implicated as a molecular target for the action of general anaesthetics. We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol...

journal_title：British journal of anaesthesia

authors： Hemmings HC Jr,Adamo AI

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam. METHODS:After ethics committee approval and consent, 40 adult patients undergoing s...

journal_title：British journal of anaesthesia

authors： Bulach R,Myles PS,Russnak M

更新日期：2005-03-01 00:00:00

abstract：:Pre- and postjunctional effects of three ethers (enflurane, diethyle ether, and methoxyflurane) and three non-ethers (chloroform, halothane, and trichloroethylene) were studied in the rat phrenic nerve diaphragm preparation using standard microelectrode recording techniques. Depression of postjunctional function inclu...

journal_title：British journal of anaesthesia

authors： Kennedy RD,Galindo AD

更新日期：1975-05-01 00:00:00

abstract：:One hundred years after Morton's demonstration of the anaesthetic effects of ether, T. Cecil Gray revolutionized anaesthesia with his introduction of balanced general anaesthesia. Gray's technique involved i.v. induction, administration of a neuromuscular blocking agent (curare), tracheal intubation, controlled ventil...

journal_title：British journal of anaesthesia

authors： Shafer SL

更新日期：2011-07-01 00:00:00

abstract：:Percutaneous dilatational tracheostomy (PDT) is associated with a number of life-threatening complications. We present a case of massive and fatal arterial haemorrhage that occurred in the intensive care unit during an elective PDT on an 86-year-old woman following earlier evacuation of a traumatic subdural haematoma....

journal_title：British journal of anaesthesia

authors： Shlugman D,Satya-Krishna R,Loh L

更新日期：2003-04-01 00:00:00

abstract：:We describe a 25 mg intrathecal morphine overdose during a combined spinal-epidural block for a Caesarean delivery. Naloxone infusion (5.24 mg over 24 h) was started prior to the patient becoming symptomatic and almost immediately after the overdose. Invasive therapeutics such as mechanical ventilation were avoided. ...

journal_title：British journal of anaesthesia

authors： Cannesson M,Nargues N,Bryssine B,Debon R,Boselli E,Chassard D

更新日期：2002-12-01 00:00:00

abstract：:We have compared, in a double-blind study, the efficacy of flumazenil with that of aminophylline in antagonizing the effects of midazolam in 60 patients (ASA I-II, mean age 66 yr) undergoing transurethral resection of prostate under spinal anaesthesia. All patients received midazolam 0.075 mg kg-1 i.v. and the test dr...

journal_title：British journal of anaesthesia

authors： Sibai AN,Sibai AM,Baraka A

更新日期：1991-05-01 00:00:00

abstract：:Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...

journal_title：British journal of anaesthesia

authors： Sturdee DW

更新日期：1976-11-01 00:00:00

abstract：:As the route of breathing and use of airway apparatus such as mask, mouthpiece and noseclip can alter breathing pattern, this study has used the helium dilution method to estimate the effects of mouthpiece and mask breathing on functional residual capacity (FRC) in the supine position, and the change in FRC that occur...

journal_title：British journal of anaesthesia

authors： Drummond GB

更新日期：1996-04-01 00:00:00

abstract：:Methodology for assessment of depth of anaesthesia based on analysis of the electroencephalogram (EEG) is controversial. Techniques range from display of single measures, for example median value of the frequency spectrum, to dedicated pattern recognition systems based on measures of several EEG features. We have comp...

journal_title：British journal of anaesthesia

authors： Thomsen CE,Prior PF

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-co...

journal_title：British journal of anaesthesia

authors： Lee JR,Jung CW,Lee YH

更新日期：2007-12-01 00:00:00

abstract：:By analysing the EEG, reticular multi-unit activity and behavioural changes, we have classified general anaesthetics into three groups: central nervous system (CNS) depressant, CNS excitant and epileptogenic agents. Changes in CNS neural activity are associated with alteration in transmitter release. We have attempted...

journal_title：British journal of anaesthesia

authors： Shichino T,Murakawa M,Adachi T,Arai T,Miyazaki Y,Mori K

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

journal_title：British journal of anaesthesia

authors： Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

更新日期：2015-03-01 00:00:00

abstract：:A recently installed anti-pollution system, initially designed to function in a passive mode, was evaluated, but found to be inconstant in its performance. A simple method of making the system active is described and evaluated. ...

journal_title：British journal of anaesthesia

authors： Asbury AJ,Hancox AJ

更新日期：1977-05-01 00:00:00

abstract：:We have evaluated the effect of delivering nitric oxide using a continuous flow system (CFS) or two commercially available proportional gas injection systems (PGIS), Nodomo (Dräger, Lübeck, Germany) and Pulmonox-Mini (Messer Griesheim Austria, Gumpoldskirchen, Austria) on measured and simulated concentrations of nitri...

journal_title：British journal of anaesthesia

authors： Hiesmayr MJ,Neugebauer T,Lassnigg A,Steltzer H,Haider W,Gilly H

更新日期：1998-10-01 00:00:00

abstract：:We have evaluated the accuracy and reliability of the Paratrend 7 continuous blood-gas analyser in infants and small children under conditions of severe hypoxaemia admitted to the paediatric intensive care unit in the perioperative period with cyanotic congenital heart disease. PO2, PCO2 and pH (hydrogen ion concentra...

journal_title：British journal of anaesthesia

authors： Hatherill M,Tibby SM,Durward A,Rajah V,Murdoch IA

更新日期：1997-11-01 00:00:00

abstract：:Development targets in anaesthetic pharmacology have evolved from minimizing harm caused by unwanted effects through an era in which rapid onset and offset of drug effect were prioritised. Today's anaesthetists have access to a library of effective drugs whose characteristics offer controllable hypnosis, analgesia and...

journal_title：British journal of anaesthesia

authors： Sneyd JR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The significance of IgE antibodies to neuromuscular blocking agent (NMBA)-induced anaphylactic reactions during anaesthesia is unclear. We investigated the relevance of IgE to rocuronium using an in vitro technique. METHODS:Serum samples from 61 patients with anaphylactic reactions during anaesthesia were i...

journal_title：British journal of anaesthesia

authors： Aalberse RC,Kleine Budde I,Mulder M,Stapel SO,Paulij W,Leynadier F,Hollmann MW

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine whether assessment of stroke volume (SV) and measurement of exhaled end-tidal carbon dioxide [Formula: see text] during an end-expiratory occlusion (EEO) test can predict fluid responsiveness in the operating theatre. METHODS:Forty-two subjects monitored by oesop...

journal_title：British journal of anaesthesia

authors： Guinot PG,Godart J,de Broca B,Bernard E,Lorne E,Dupont H

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:There has been a renewed interest in nitric oxide donor drugs, such as nitroglycerin, delivered by the inhalational route for treatment of pulmonary arterial hypertension (PAH). We investigated the acute effects of inhaled nitroglycerin on pulmonary and systemic haemodynamics in children with PAH associated ...

journal_title：British journal of anaesthesia

authors： Goyal P,Kiran U,Chauhan S,Juneja R,Choudhary M

更新日期：2006-08-01 00:00:00

abstract：:We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...

journal_title：British journal of anaesthesia

authors： Lopez-Gil M,Brimacombe J,Brain AI

更新日期：1999-01-01 00:00:00