End-expiratory occlusion manoeuvre does not accurately predict fluid responsiveness in the operating theatre.

abstract：Background:Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing animal brain, including those of non-human primates (NHPs), anaesthetics induce apoptotic cell death. We previously reported that a 5 h isoflurane (ISO...

journal_title：British journal of anaesthesia

authors： Noguchi KK,Johnson SA,Dissen GA,Martin LD,Manzella FM,Schenning KJ,Olney JW,Brambrink AM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established. It is also unclear if ...

journal_title：British journal of anaesthesia

authors： Friederich P,Solth A,Schillemeit S,Isbrandt D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine (DEX) has been shown to provide good perioperative haemodynamic stability with decreased intraoperative opioid requirements. It may have neural protective effects, and thus may be a suitable anaesthetic adjuvant to neurosurgical anaesthesia. METHODS:Fifty-four patients scheduled for elective...

journal_title：British journal of anaesthesia

authors： Tanskanen PE,Kyttä JV,Randell TT,Aantaa RE

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The ilioinguinal/iliohypogastric nerve block is a popular regional anaesthetic technique for children undergoing inguinal surgery. The success rate is only 70-80% and complications may occur. A prospective randomized double-blinded study was designed to compare the use of ultrasonography with the conventiona...

journal_title：British journal of anaesthesia

authors： Willschke H,Marhofer P,Bösenberg A,Johnston S,Wanzel O,Cox SG,Sitzwohl C,Kapral S

更新日期：2005-08-01 00:00:00

abstract：:The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubocurarine). Sedation for patients breathing spontaneously with positive airway pressure was conti...

journal_title：British journal of anaesthesia

authors： Booker PD,Beechey A,Lloyd-Thomas AR

更新日期：1986-10-01 00:00:00

abstract：:Thirty patients for elective lower segment Caesarean section were randomly divided into two groups. One group received 50 mulitre/kg of Althesin for induction of anaesthesia and the other, 100 mulitre/kg. The two maternal groups were similar. There was no significant difference in the clinical or biochemical status of...

journal_title：British journal of anaesthesia

authors： Holdcroft A,Morgan M,Gordon H,Whitwam JG,White Y

更新日期：1975-11-01 00:00:00

abstract：:Cerebral emboli detected by transcranial Doppler imaging were recorded in 20 patients undergoing multiple-vessel coronary artery bypass surgery, either with or without cardiopulmonary bypass, in a prospective unblinded comparative study. Emboli were recorded continuously from the time of pericardial incision until 10 ...

journal_title：British journal of anaesthesia

authors： Watters MP,Cohen AM,Monk CR,Angelini GD,Ryder IG

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) monitor has been suggested as a potential tool to measure depth of sedation in paediatric intensive care unit (PICU) patients. The primary aim of our observational study was to assess the difference in BIS values between the left and right sides of the brain. Secondary aims were to...

journal_title：British journal of anaesthesia

authors： Froom SR,Malan CA,Mecklenburgh JS,Price M,Chawathe MS,Hall JE,Goodwin N

更新日期：2008-05-01 00:00:00

abstract：:The majority of patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation. This support provides time for the lungs to heal, but the adverse effects of mechanical ventilation significantly influence patient outcome. Traditionally, these were ascribed to mechanical effects, such as haemody...

journal_title：British journal of anaesthesia

authors： Moloney ED,Griffiths MJ

更新日期：2004-02-01 00:00:00

abstract：:Haemodynamic effects may occur after stellate ganglion block (SGB) arising from autonomic imbalance and local anaesthetic infiltration to barosensitive areas. We report seven patients who developed severe hypertension (systolic arterial pressure >200 mm Hg) after SGB in our pain clinic service. We postulate that diffu...

journal_title：British journal of anaesthesia

authors： Kimura T,Nishiwaki K,Yokota S,Komatsu T,Shimada Y

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Anaesthetics suppress the formation of lasting memories at concentrations that do not suppress perception, but it is unclear which elements of the complex cascade leading from a conscious experience to a lasting memory trace are disrupted. Experiments in conscious humans suggest that subhypnotic concentratio...

journal_title：British journal of anaesthesia

authors： Pearce RA,Duscher P,Van Dyke K,Lee M,Andrei AC,Perouansky M

更新日期：2012-04-01 00:00:00

abstract：:Twenty consecutive patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were allocated at random to group 1 (n = 10, high inspired oxygen fraction (FIO2) after CPB), or group 2 (n = 10, moderate FIO2 after CPB). The effects of each FIO2 on arterial and mixed venous concentrations of endothelin-1 (ET-1...

journal_title：British journal of anaesthesia

authors： Reber A,Budmiger B,Wenk M,Haefeli WE,Wolff T,Bein T,Skarvan K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The immobilizing effects of volatile anaesthetics are primarily mediated at the spinal level. A suppression of recurrent spinal responses (F-waves), which reflect spinal excitability, has been shown for propofol. We have assessed the concentration-dependent F-wave suppression by propofol and related it to th...

journal_title：British journal of anaesthesia

authors： Baars JH,Tas S,Herold KF,Hadzidiakos DA,Rehberg B

更新日期：2006-01-01 00:00:00

abstract：:Dose-response relationships for the antagonism of intermediate-acting neuromuscular blocking agents have not been evaluated previously in children. We have examined the dose-response relationships for neostigmine antagonism of 90% rocuronium-induced neuromuscular block in children and adults, during nitrous oxide-1 MA...

journal_title：British journal of anaesthesia

authors： Abdulatif M,Mowafi H,al-Ghamdi A,el-Sanabary M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:The efficacy of opioids typically decreases after long-term use owing to the development of tolerance. Glial activation and the upregulation of proinflammatory cytokines are related to the induction of tolerance. We investigated the effect of leukemia inhibitory factor (LIF) on morphine analgesia and toleran...

journal_title：British journal of anaesthesia

authors： Tu HJ,Kang KH,Ho SY,Liou HC,Liou HH,Lin CP,Fu WM

更新日期：2016-10-01 00:00:00

abstract：:In the prone knee-chest position the spread of plain 0.5% bupivacaine in the cerebrospinal fluid and associated haemodynamic changes may be different compared with the horizontal position. A randomized comparison was performed in 40 ASA I-II patients, aged 24-61 yr, undergoing lumbar disc surgery. Subarachnoid injecti...

journal_title：British journal of anaesthesia

authors： Laakso E,Pitkänen M,Kyttä J,Rosenberg PH

更新日期：1997-11-01 00:00:00

abstract：:We have studied the effect of clonidine, dexmedetomidine and morphine on gastric emptying and gastrointestinal transit in the rat. In one group, each agonist was injected i.p. in 6-12 male Wistar rats. In another group of rats, yohimbine, naloxone or saline was injected with an agonist. At 30 min, radiolabelled saline...

journal_title：British journal of anaesthesia

authors： Asai T,Mapleson WW,Power I

更新日期：1997-03-01 00:00:00

abstract：:Bupivacaine (0.5%) 20 ml was administered extradurally to six healthy volunteers. It was found that simultaneous application of 10 needles to the skin could evoke pain when analgesia was obtained to one needle stimulation. In addition, a laser beam was used as a quantitative technique to activate simultaneously many c...

journal_title：British journal of anaesthesia

authors： Adrendt-Nielsen L,Oberg B,Bjerring P

更新日期：1990-11-01 00:00:00

abstract：:Mice, previously immunized with sheep erythrocytes, were anaesthetized with halothane and the splenic lymphoid cells were incubated with 3H-thymidine at 1-h intervals. Abiphasic response was observed; 0.9 and 1.5% halothane reduced 3H-thymidine incorporation into the primed lymphoid cells by 83 and 94% respectively, w...

journal_title：British journal of anaesthesia

authors： Bandoh T,Fujita T

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Recent studies have shown that ultrasound guidance for paediatric regional anaesthesia can improve the quality of upper extremity and neuraxial blocks. We therefore investigated whether ultrasound guidance for sciatic and femoral nerve blocks prolongs sensory blockade in comparison with nerve stimulator guid...

journal_title：British journal of anaesthesia

authors： Oberndorfer U,Marhofer P,Bösenberg A,Willschke H,Felfernig M,Weintraud M,Kapral S,Kettner SC

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:A significantly increased risk of acute kidney injury (AKI) with the prophylactic use of aprotinin has been reported in adults undergoing cardiac surgery, but not in children. Blood product transfusions have also been shown to carry an independent risk of AKI. The present study assessed associations between ...

journal_title：British journal of anaesthesia

authors： Bojan M,Vicca S,Boulat C,Gioanni S,Pouard P

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The esCCO monitor (ECG- estimated Continuous Cardiac Output, Nihon Kohden(®)) is a new non-invasive tool for estimating cardiac output (CO). It derives CO from the pulse wave transit time (PWTT) estimated by the ECG and the plethysmographic wave. An initial calibration is needed to refine the relation linkin...

journal_title：British journal of anaesthesia

authors： Bataille B,Bertuit M,Mora M,Mazerolles M,Cocquet P,Masson B,Moussot PE,Ginot J,Silva S,Larché J

更新日期：2012-12-01 00:00:00

abstract：:We have evaluated the clinical utility and blood propofol concentrations produced with two different infusion regimens for propofol, given to supplement 67% nitrous oxide-morphine anaesthesia. Patients received a standardized three-step infusion of propofol based either on body weight (weight-corrected group) or on a ...

journal_title：British journal of anaesthesia

authors： Sear JW,Glen JB

更新日期：1995-04-01 00:00:00

abstract：:Following a paravertebral surgical incision, mature, female rats under ether anaesthesia were exposed to either 3% nitrous oxide, continuously for 48 h, or 50% nitrous oxide, 4 h each day for 7 days. For each exposure group, a similar number of rats was exposed to atmospheres containing no nitrous oxide. Wound healing...

journal_title：British journal of anaesthesia

authors： Algie TA,Seth A,Barbenel JC,Galloway DJ,Gray WM,Spence AA

更新日期：1985-06-01 00:00:00

abstract：:The coherent frequency (CF) of the auditory evoked response (AER) is derived using auditory clicks presented at frequencies in the range 5-47 Hz. CF and psychological performance were measured while seven subjects breathed isoflurane in doses increasing from 0% to 0.2%, 0.4% and 0.8% end-tidal concentration and then d...

journal_title：British journal of anaesthesia

authors： Munglani R,Andrade J,Sapsford DJ,Baddeley A,Jones JG

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Recent research into memory formation under sedation has generated conflicting results. We investigated explicit and implicit memory in ICU patients during moderate to deep propofol sedation following cardiac surgery. METHODS:Two different methods of memory testing were used; (1). free-association (F-A) wor...

journal_title：British journal of anaesthesia

authors： Clark J,Voss L,Barnard J,Sleigh J

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Multiple studies have shown that cerebral tissue oxygen saturation (Sct(O(2))) is decreased after phenylephrine treatment. We hypothesized that the negative impact of phenylephrine administration on Sct(O(2)) is affected by arterial blood carbon dioxide partial pressure (Pa(CO(2))) because CO(2) is a powerfu...

journal_title：British journal of anaesthesia

authors： Meng L,Gelb AW,Alexander BS,Cerussi AE,Tromberg BJ,Yu Z,Mantulin WW

更新日期：2012-05-01 00:00:00

abstract：:We have compared the effects of dexmedetomidine and propofol on endocrine, metabolic, inflammatory and cardiovascular responses in patients in the intensive care unit (ICU) after major surgery. Twenty patients who were expected to require 8 h of post-operative sedation and ventilation were allocated randomly to receiv...

journal_title：British journal of anaesthesia

authors： Venn RM,Bryant A,Hall GM,Grounds RM

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Investigators planning dose-response studies of neuromuscular blockers have rarely used a priori power analysis to determine the minimal sample size their protocols require. Institutional Review Boards and peer-reviewed journals now generally ask for this information. This study outlines a proposed method fo...

journal_title：British journal of anaesthesia

authors： Kopman AF,Lien CA,Naguib M

更新日期：2011-02-01 00:00:00

abstract：:The 119 patients who had undergone previous Caesarean section lumbar extradural block was administered to 77 (65%); the other 42 (35%) received analgesia with ketobemidone 0.8-1.0 ml i.m. or nitrous oxide in oxygen intermittently, or both. Controlled i.v. infusion of oxytocin for induction or acceleration of labour wa...

journal_title：British journal of anaesthesia

authors： Carlsson C,Nybell-Lindahl G,Ingemarsson I

更新日期：1980-08-01 00:00:00