Effects of propofol vs sevoflurane on arterial oxygenation during one-lung ventilation.

Abstract:

BACKGROUND:The inhibitory effect of anaesthetic agents on hypoxic pulmonary vasoconstriction may depend upon their dose, especially when using a volatile agent. The aim of this randomized open study was to compare the effects of sevoflurane and propofol, as primary anaesthetic agents, on oxygenation during one-lung ventilation (OLV), with their administration being adjusted to maintain bispectral index (BIS) values between 40 and 60. METHODS:Eighty patients scheduled for a lobectomy, receiving an epidural mixture of ropivacaine and sufentanil, were randomly assigned to Group S (maintenance with sevoflurane) or Group P (maintenance with propofol). After placement of a double-lumen tube, the lungs were ventilated at an inspiratory fraction of oxygen of 1.0, a tidal volume of 6 ml kg(-1), and 12 bpm. Arterial blood gas samples were taken as follows: during two-lung ventilation before OLV, and during the first 40 min of OLV. RESULTS:Fifteen patients were excluded (incorrect placement of the tube or BIS outside the desired range). The two groups were comparable in terms of demographic variables, haemodynamic, and BIS levels during the operation. Four patients in each group had a Sp(O2)<90%. Mean of the lowest Pa(O2) was 16.3 (7.5) kPa in Group S and 17.7 (9.3) kPa in Group P (ns). CONCLUSIONS:Sevoflurane and propofol had similar effect on Pa(O2) during OLV when their administration is titrated to maintain BIS between 40 and 60.

journal_name

Br J Anaesth

authors

Pruszkowski O,Dalibon N,Moutafis M,Jugan E,Law-Koune JD,Laloë PA,Fischler M

doi

10.1093/bja/aem039

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

539-44

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)35509-5

journal_volume

98

pub_type

杂志文章,随机对照试验
  • Excitatory and inhibitory synaptic mechanisms in anaesthesia.

    abstract::To understand the cellular and molecular basis of the anaesthetic state, it is important to remember that, in the intact CNS, synapses operate within elaborate nerve networks. From the data presented above, it is evident that block of impulse conduction in presynaptic fibres does not explain the effects of most anesth...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/71.1.134

    authors: Pocock G,Richards CD

    更新日期:1993-07-01 00:00:00

  • Comparison of the new emulsion formulation of propofol with methohexitone and thiopentone for induction of anaesthesia in day cases.

    abstract::The new emulsion formulation of di-isopropyl phenol (propofol) was compared with methohexitone and thiopentone for induction of anaesthesia in day cases. Propofol produced significantly smoother induction of anaesthesia, but caused more cardiovascular and respiratory depression. Pain on injection was significantly les...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/57.8.725

    authors: Mackenzie N,Grant IS

    更新日期:1985-08-01 00:00:00

  • Abilities of pulse pressure variations and stroke volume variations to predict fluid responsiveness in prone position during scoliosis surgery.

    abstract:BACKGROUND:Pulse pressure variation (PPV) and stroke volume variation (SVV) are robust indicators of fluid responsiveness in mechanically ventilated supine patients. The aim of the study was to evaluate the ability of PPV and SVV to predict fluid responsiveness in mechanically ventilated patients in the prone position ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq031

    authors: Biais M,Bernard O,Ha JC,Degryse C,Sztark F

    更新日期:2010-04-01 00:00:00

  • Fatal myocardial infarction after lung resection in a patient with prophylactic preoperative coronary stenting.

    abstract::In this report we present the case of a 77-yr-old man who underwent resection of the upper lobe of the left lung for a carcinoma, six weeks after percutaneous transluminal coronary angioplasty (PTCA) with stenting of the left anterior descending (LAD) and circumflex coronary arteries. Antiplatelet therapy with clopido...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeh110

    authors: Marcucci C,Chassot PG,Gardaz JP,Magnusson L,Ris HB,Delabays A,Spahn DR

    更新日期:2004-05-01 00:00:00

  • Lung protective strategies in anaesthesia.

    abstract::Patients are at risk for several types of lung injury in the perioperative period including atelectasis, pneumonia, pneumothorax, acute lung injury, and acute respiratory distress syndrome. Anaesthetic management can cause, exacerbate, or ameliorate these injuries. This review examines the effects of perioperative mec...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aeq299

    authors: Kilpatrick B,Slinger P

    更新日期:2010-12-01 00:00:00

  • Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis.

    abstract:BACKGROUND:Patients undergoing non-cardiac, non-vascular surgery are at risk of major cardiovascular complications. In non-cardiac surgery, troponin elevation has previously been shown to be an independent predictor of major adverse cardiac events and postoperative mortality; however, a majority of studies have focused...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aew321

    authors: Ekeloef S,Alamili M,Devereaux PJ,Gögenur I

    更新日期:2016-11-01 00:00:00

  • Monitoring of end-tidal carbon dioxide partial pressure during high frequency jet ventilation.

    abstract::A new method has been developed to measure end-tidal carbon dioxide partial pressure (PECO2) during high frequency jet ventilation (HFJV). A digital flow controller incorporated in a computerized high frequency jet ventilator was used to deliver either a single deep breath or a series of three deep breaths. On user re...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/63.7.47

    authors: Sehati S,Young JD,Sykes MK,McLeod CN

    更新日期:1989-01-01 00:00:00

  • Effect of airway occlusion on respiratory timing during anaesthesia with enflurane or halothane.

    abstract::Eighteen patients were studied, during operations under subarachnoid or extradural anaesthesia combined with general anaesthesia, to assess the influence of occlusion of inspiration on the duration of inspiration, and the likelihood of a relationship between lung volume and duration of inspiration. Ten patients breath...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.3.215

    authors: Drummond GB

    更新日期:1984-03-01 00:00:00

  • A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery.

    abstract::The effects of i.m. dexmedetomidine 1.0 micrograms kg-1, a new alpha 2-adrenoceptor agonist, were compared with those of i.m. midazolam 0.08 mg kg-1 and placebo on vigilance, anaesthetic requirements, haemodynamic state and plasma catecholamine concentrations in a double-blind placebo-controlled study in 107 healthy (...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/67.4.402

    authors: Aantaa R,Jaakola ML,Kallio A,Kanto J,Scheinin M,Vuorinen J

    更新日期:1991-10-01 00:00:00

  • Cardiovascular effects of propofol in the anaesthetized dog.

    abstract::This study was designed to investigate if propofol produced cardiovascular effects by direct actions or by indirect actions secondary to depression of the central nervous system. Experiments were performed on chloralose anaesthetized dogs in which all neurogenic cardiovascular reflexes were abolished by bilateral vago...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/63.1.87

    authors: Goodchild CS,Serrao JM

    更新日期:1989-07-01 00:00:00

  • Nitrous oxide antagonizes CNS stimulation by laudanosine in mice.

    abstract::We have investigated whether nitrous oxide antagonizes or augments the CNS stimulant action of laudanosine in mice by comparing the mean convulsive doses (CD50 (SE] of a control group and those following pretreatment with 65% nitrous oxide in oxygen for 20 and 180 min. Nitrous oxide significantly increased CD50 from 4...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/65.5.704

    authors: Avramov MN,Mori K

    更新日期:1990-11-01 00:00:00

  • The pneuPAC hyperbaric variant HB: a ventilator suitable for use within a one-man hyperbaric chamber.

    abstract::We describe the performance of the pneuPAC hyperbaric variant HB, a ventilator designed for use in a one-man hyperbaric chamber. The ventilator delivered minute volumes of 11-23 litre at 1 atm abs to 7.6-16 litre at 2.5 atm abs. The delivered minute volume may be controlled easily from outside the chamber by manipulat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/67.4.488

    authors: Spittal MJ,Hunter SJ,Jones L

    更新日期:1991-10-01 00:00:00

  • Extradural morphine for the relief of pain following caesarean section.

    abstract::Thirty patients took part in a double-blind trial to compare morphine 10 mg i.m. with morphine 5 mg into the extradural space for pain relief following Caesarean section. With the extradural route the mean time to first analgesia was 7.95 h compared with 4.75 h for the i.m. route. The mean number of further doses of d...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/55.12.1201

    authors: Chambers WA,Mowbray A,Wilson J

    更新日期:1983-12-01 00:00:00

  • Modification of the iso-shunt lines for low inspired oxygen concentrations.

    abstract::Arterial PO2 (PaO2) has been related to inspired oxygen concentration (FIO2 range 0.21-0.60) in 20 patients, breathing spontaneously, while recovering from a range of conditions treated in an intensive therapy unit. There was a highly significant linear trend (P < 0.001) for the mean venous admixture ("virtual shunt")...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/72.5.515

    authors: Petros AJ,Doré CJ,Nunn JF

    更新日期:1994-05-01 00:00:00

  • Electromyographic assessment of neuromuscular block at the gastrocnemius muscle.

    abstract::We have assessed neuromuscular block electromyographically at the gastrocnemius muscle and compared it with that at the abductor digiti minimi muscle in 60 adult patients undergoing cervical spine surgery under general anaesthesia. All patients were in the prone position. After vecuronium 0.2 mg kg-1, times to onset o...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,收录出版

    doi:10.1093/bja/82.3.329

    authors: Saitoh Y,Narumi Y,Fujii Y,Ueki M,Makita K

    更新日期:1999-03-01 00:00:00

  • Inhalation induction with sevoflurane: a double-blind comparison with propofol.

    abstract::We conducted a randomized, double-blind comparison of 8% sevoflurane and propofol as induction agents for day-case cystoscopy in 102 patients. All patients received an i.v. cannula and breathed oxygen 5 litre min-1. Anaesthesia was induced with propofol i.v. or inhalation of 8% sevoflurane and 10% Intralipid (as a pla...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/78.4.356

    authors: Thwaites A,Edmends S,Smith I

    更新日期:1997-04-01 00:00:00

  • Priming and the onset of neuromuscular blockade with alcuronium.

    abstract::"Priming" with alcuronium has been studied in 72 female patients. Blockade of single twitch responses of the adductor pollicis by alcuronium 0.15, 0.2 or 0.3 mg kg-1 could be accelerated by priming with a suitable priming portion of the total dose. Giving alcuronium 0.04 mg kg-1 30 s after the induction of anaesthesia...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/58.8.827

    authors: Black AM,Hutton P,el-Hassan KM,Morgan G,Clutton-Brock TH

    更新日期:1986-08-01 00:00:00

  • Survival from massive intraoperative pulmonary thromboembolism during orthotopic liver transplantation.

    abstract::We report a case of massive pulmonary embolism occurring at the time of graft reperfusion in a patient undergoing orthotopic liver transplantation. The clinical diagnosis of pulmonary embolus was aided by on-table echocardiography. Cardiopulmonary bypass and surgical embolectomy prevented her death. We discuss the dif...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/80.5.685

    authors: Manji M,Isaac JL,Bion J

    更新日期:1998-05-01 00:00:00

  • Comparison of sevoflurane and halothane for outpatient dental anaesthesia in children.

    abstract::In a prospective, randomized, double-blind clinical study, we have studied 100 children, aged 2-12 yr, to compare halothane and sevoflurane in outpatient dental anaesthesia. All patients were unpremedicated and received inhalation induction using nitrous oxide in oxygen supplemented with either halothane (maximum insp...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/79.3.280

    authors: Paris ST,Cafferkey M,Tarling M,Hancock P,Yate PM,Flynn PJ

    更新日期:1997-09-01 00:00:00

  • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.

    abstract::The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery (trapeziectomy). Further investigations revealed a lifelong history...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2019.02.019

    authors: Habib AM,Okorokov AL,Hill MN,Bras JT,Lee MC,Li S,Gossage SJ,van Drimmelen M,Morena M,Houlden H,Ramirez JD,Bennett DLH,Srivastava D,Cox JJ

    更新日期:2019-08-01 00:00:00

  • Improvement in i.v. regional anaesthesia by re-exsanguination before surgery.

    abstract::A modification of an i.v. regional anaesthesia (IVRA) technique is described in which the arm is re-exsanguinated before surgery (re-IVRA). IVRA and re-IVRA were compared for quality of operative field, sensory and motor block, quality of analgesia and blood concentrations of prilocaine, lignocaine and mepivacaine in ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/70.3.280

    authors: Rawal N,Hallén J,Amilon A,Hellstrand P

    更新日期:1993-03-01 00:00:00

  • Determinants of outcome in critically ill octogenarians after surgery: an observational study.

    abstract:BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aem307

    authors: Ford PN,Thomas I,Cook TM,Whitley E,Peden CJ

    更新日期:2007-12-01 00:00:00

  • Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group.

    abstract::Neurone specific enolase (NSE) and S-100 beta protein have been used as markers of brain damage. We hypothesized that blood concentrations of NSE and S-100 beta protein reflect cognitive dysfunction after abdominal surgery. We studied 65 elderly patients in whom neuropsychological testing was performed before abdomina...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.bja.a013410

    authors: Rasmussen LS,Christiansen M,Rasmussen H,Kristensen PA,Moller JT

    更新日期:2000-02-01 00:00:00

  • The skeletal muscle response to edrophonium during neuromuscular blockade by tubocurarine in anaesthetized man.

    abstract::Tetanic contractions of the adductor pollicis muscle in man were evaluated continuously after the administration of tubocurarine 0.2 mg/kg and during reversal by edrophonium 0.1 mg/kg. Single twitch contractions of the adductor pollicis were measured simultaneously. The response of tetanic and single twitch contractio...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/47.10.1087

    authors: Sugai N,Payne JP

    更新日期:1975-10-01 00:00:00

  • Spinal anaesthesia with hyperbaric bupivacaine. Effects of age on neural blockade and pharmacokinetics.

    abstract::Effects of ageing were studied on the neural blockade and the pharmacokinetics after subarachnoid administration of 0.5% bupivacaine 3 ml in 8% glucose in two groups of 15 male patients, between 20 and 55 yr and older than 55 yr, respectively. The blockade was performed with the patient in the sitting position. Two mi...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/60.2.187

    authors: Veering BT,Burm AG,Spierdijk J

    更新日期:1988-02-01 00:00:00

  • Effect of tropisetron, a 5-HT3 receptor antagonist, on analgesia and nausea after intrathecal morphine.

    abstract::We have studied the effect of tropisetron, a 5-HT3-receptor antagonist, on postoperative nausea, vomiting and pain in 54 patients, aged 50-83 yr, after major hip or knee surgery. The patients were given subarachnoid injection of plain 0.5% bupivacaine, mixed with preservative-free morphine 0.3 mg, for surgical and pos...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/71.5.681

    authors: Pitkänen MT,Niemi L,Tuominen MK,Rosenberg PH

    更新日期:1993-11-01 00:00:00

  • Ventilatory effects of laparoscopy under general anaesthesia.

    abstract::We have studied 14 female patients undergoing elective laparoscopy under general anaesthesia with peritoneal insufflation of carbon dioxide in order to examine changes in physiological deadspace (VDphys), arterial to end-tidal carbon dioxide partial pressure difference (PaCO2-PE' CO2) and PaCO2. VCO2 increased after i...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/68.2.211

    authors: Puri GD,Singh H

    更新日期:1992-02-01 00:00:00

  • Effects of chronic angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor treatments on neurohormonal levels and haemodynamics during cardiopulmonary bypass.

    abstract:BACKGROUND:Chronic treatment with renin-angiotensin system (RAS) antagonists frequently causes deleterious hypotension during anaesthesia. We compared the effects of angiotensin II receptor antagonists (ARA) and angiotensin-converting enzyme inhibitors (ACEI) on neurohormonal levels and haemodynamics during cardiopulmo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael268

    authors: Oh YJ,Lee JH,Nam SB,Shim JK,Song JH,Kwak YL

    更新日期:2006-12-01 00:00:00

  • Anaesthetic care of patients undergoing primary hip and knee arthroplasty: consensus recommendations from the International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) based on a systematic review and meta-analysis.

    abstract:BACKGROUND:Evidence-based international expert consensus regarding anaesthetic practice in hip/knee arthroplasty surgery is needed for improved healthcare outcomes. METHODS:The International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) systematic review, including randomised controlled and ob...

    journal_title:British journal of anaesthesia

    pub_type: 共识发展会议,杂志文章,meta分析

    doi:10.1016/j.bja.2019.05.042

    authors: Memtsoudis SG,Cozowicz C,Bekeris J,Bekere D,Liu J,Soffin EM,Mariano ER,Johnson RL,Hargett MJ,Lee BH,Wendel P,Brouillette M,Go G,Kim SJ,Baaklini L,Wetmore D,Hong G,Goto R,Jivanelli B,Argyra E,Barrington MJ,Borgea

    更新日期:2019-09-01 00:00:00

  • The role of histamine in the cardiovascular effects of atracurium.

    abstract::We have investigated the effect of a bolus injection of atracurium 0.6 mg kg-1 on the cardiovascular system in 16 patients undergoing aortocoronary bypass surgery. H1- and H2-receptor antagonists were administered to eight patients before the neuromuscular blocker. A standard anaesthetic was used comprising fentanyl, ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/68.2.155

    authors: Adt M,Baumert JH,Reimann HJ

    更新日期:1992-02-01 00:00:00