Abstract:
:We have compared the anaesthetic and analgesic efficacy of levobupivacaine with that of racemic bupivacaine in 66 male patients undergoing ambulatory primary inguinal herniorrhaphy. Patients were allocated randomly in a double-blind manner to local infiltration anaesthesia (0.25% w/v 50 ml) with either racemic bupivacaine (n = 33) or levobupivacaine (n = 33). Scores for intraoperative pain and satisfaction with anaesthesia were recorded, together with perception of postoperative pain and need for supplementary postoperative analgesic medications in the first 48 h after operation. Intraoperative satisfaction with the infiltration anaesthesia was similar, with median scores of 77 (levobupivacaine) and 80 (bupivacaine) (VAS; 100 mm = extremely satisfied). Time averaged postoperative pain scores (48 h) were 8 (levobupivacaine) and 10 (bupivacaine) in the supine position, 13 (levobupivacaine) and 12 (bupivacaine) while rising from the supine position to sitting, and 9 (levobupivacaine) and 13 (bupivacaine) while walking (VAS; 100 mm = worst pain imaginable) (ns). There was no difference in the use of peroral postoperative analgesics between the two groups. We conclude that racemic bupivacaine and its S-enantiomer levobupivacaine had similar efficacy when used as local infiltration anaesthesia in inguinal herniorrhaphy.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Bay-Nielsen M,Klarskov B,Bech K,Andersen J,Kehlet Hdoi
10.1093/bja/82.2.280subject
Has Abstractpub_date
1999-02-01 00:00:00pages
280-2issue
2eissn
0007-0912issn
1471-6771pii
S0007-0912(17)38204-1journal_volume
82pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The objective of the present study was to investigate sublingual microvascular blood flow and microcirculatory haemoglobin oxygen saturation (Smc(O(2))) during cardiopulmonary bypass (CPB) using constant systemic blood flow but different perfusion pressures achieved by phenylephrine administration. METHODS:...
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更新日期:2009-04-01 00:00:00
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journal_title:British journal of anaesthesia
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journal_title:British journal of anaesthesia
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-03-01 00:00:00
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更新日期:2001-09-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章
doi:10.1093/bja/52.8.817
更新日期:1980-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-08-01 00:00:00