Viability criterion of muscle bundles used in the in vitro contracture test in patients with neuromuscular diseases.

Abstract:

:We have compared the viability criteria of muscle bundles used in the in vitro contracture test for susceptibility to malignant hyperthermia (MH) in a group of 28 patients with various neuromuscular diseases (NMD) and 93 MH-related family patients. In the patients with NMD, this standard test gave one positive, six equivocal and 21 negative results. Compared with MH-related family patients, muscle bundles used had significantly smaller resting membrane potentials and smaller predrug twitch tension amplitudes. Some results from the group with NMD were obtained with muscles which were damaged, more rapidly deteriorating, non-standard or both, and should not be taken to indicate that the patients have the genetic trait for MH. The in vitro contracture test is not always relevant for myopathic muscle (especially dystrophic muscle) and this could explain the lack of specificity for MH.

journal_name

Br J Anaesth

authors

Adnet PJ,Krivosic-Horber RM,Krivosic I,Haudecoeur G,Reyford HG,Adamantidis MM,Medahoui H

doi

10.1093/bja/72.1.93

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

93-7

issue

1

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45568-1

journal_volume

72

pub_type

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