Studies on morphine disposition: influence of general anaesthesia on plasma concentrations of morphine and its metabolites.

abstract：:We describe a six-compartment physiological model of the kinetics and dynamics of induction of anaesthesia with propofol in sheep. It includes a faithful description of initial bolus kinetics caused by accurate representations of the inter-relationships between initial vascular mixing, lung kinetics and cardiac output...

journal_title：British journal of anaesthesia

authors： Upton RN,Ludbrook GL

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine has been proposed as a perineural local anaesthetic (LA) adjunct to prolong peripheral nerve block duration; however, results from our previous meta-analysis in the setting of brachial plexus block (BPB) did not support its use. Many additional randomized trials have since been published. We ...

journal_title：British journal of anaesthesia

authors： Vorobeichik L,Brull R,Abdallah FW

更新日期：2017-02-01 00:00:00

abstract：:Summary While complex physiological mechanisms exist to regulate and optimize tissue oxygenation under various conditions, clinical and experimental evidence indicates that anaemia, unchecked, is associated with organ injury and unfavourable outcomes. More data (especially from human studies) are needed to answer ques...

journal_title：British journal of anaesthesia

authors： Shander A,Javidroozi M,Ozawa S,Hare GM

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...

journal_title：British journal of anaesthesia

authors： Bergström A,Staalsø JM,Romner B,Olsen NV

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Pressures (Pe) exerted by bronchial blockers on the inner wall of the bronchi may cause mucosal ischaemia. Our aims were as follows: (i) to compare the intracuff pressure (Pi) and Pe exerted by commercially available bronchial blockers in an in vitro and an ex vivo model; (ii) to investigate the influence of...

journal_title：British journal of anaesthesia

authors： Carassiti M,Mattei A,Pizzo CM,Vallone N,Saccomandi P,Schena E

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The oesophageal leak pressure is defined as the pressure which breaks the seal between the cuff of a supraglottic airway and the peri-cuff mucosa, allowing penetration of fluid into the pharynx and the oral cavity. As a consequence, a decrease in this variable increases the risk of reflux and can lead to pul...

journal_title：British journal of anaesthesia

authors： Hensel M,Schmidbauer W,Geppert D,Sehner S,Bogusch G,Kerner T

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Midlatency auditory evoked potentials (MLAEP) are a promising tool for monitoring suppression of sensory processing during anaesthesia and might help to avoid awareness. MLAEP in children are different to those in adults and the exact changes during general anaesthesia are unknown. METHODS:In 49 children of...

journal_title：British journal of anaesthesia

authors： Daunderer M,Feuerecker MS,Scheller B,Pape NB,Schwender D,Kuhnle GE

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Muscle relaxants facilitate tracheal intubation, but they are often not used for short peripheral surgical procedures. The consequences of this practice on the upper airway are still a matter of controversy. We therefore compared the incidence of post-intubation symptoms in a randomized study comparing patie...

journal_title：British journal of anaesthesia

authors： Combes X,Andriamifidy L,Dufresne E,Suen P,Sauvat S,Scherrer E,Feiss P,Marty J,Duvaldestin P

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Medication-related adverse events (MRE) in anaesthesia care are frequent and require a deeper understanding if we are to prevent medication harm. METHODS:We searched for reported MRE from the Spanish Anaesthesia Incident Reporting System (SENSAR) database over a 10-yr period. SENSAR is a cross-national, mul...

journal_title：British journal of anaesthesia

authors： Sanduende-Otero Y,Villalón-Coca J,Romero-García E,Díaz-Cambronero Ó,Barach P,Arnal-Velasco D

更新日期：2020-02-01 00:00:00

abstract：:We have examined the effects of sedation with midazolam 0.1 mg kg-1 and reversal with flumazenil 0.5 mg on beat-to-beat heart rate (HR) variability (HRV), systolic arterial pressure (SAP), finger photoplethysmograph amplitude (PLA) and impedence pneumography in eight volunteers. With the onset of sedation there was a ...

journal_title：British journal of anaesthesia

authors： Galletly DC,Williams TB,Robinson BJ

更新日期：1996-04-01 00:00:00

abstract：:Thiopental is a racemate of equimolar R- and S-thiopental enantiomers that have different potencies in laboratory experiments. We measured concentrations of R- and S-thiopental in plasma, tissues and brain microdialysate of rats after computer-controlled infusion of thiopental i.v. to a plasma concentration of 40 micr...

journal_title：British journal of anaesthesia

authors： Mather LE,Edwards SR,Duke CC,Cousins MJ

更新日期：2000-01-01 00:00:00

abstract：:Cardiovascular risk prediction using clinical risk factors is integral to both the European and the American algorithms for preoperative cardiac risk assessment and perioperative management for non-cardiac surgery. We have reviewed these risk factors and their ability to guide clinical decision making. We examine thei...

journal_title：British journal of anaesthesia

authors： Biccard BM,Rodseth RN

更新日期：2011-08-01 00:00:00

abstract：:The time course of the plasma lignocaine concentration, following caudal anaesthesia, was studied in 11 healthy children (3.5-9 yr). Plasma lignocaine concentrations were measured for up to 6 h after administration (5 mg kg-1). Peak plasma concentration was 2.05 +/- 0.08 micrograms ml-1 and occurred at 28.2 +/- 2.9 mi...

journal_title：British journal of anaesthesia

authors： Ecoffey C,Desparmet J,Berdeaux A,Maury M,Giudicelli JF,Saint-Maurice C

更新日期：1984-12-01 00:00:00

abstract：:Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenaline 10 mumol litre-1 was used as a control. In contrast with noradrenaline...

journal_title：British journal of anaesthesia

authors： Desborough JP,Jones PM,Persaud SJ,Howell SL

更新日期：1993-02-01 00:00:00

abstract：:The effects of bolus doses of phenoperidine 1-2 mg i.v. either alone, or combined with pancuronium 2-4 mg, were investigated in seven patients in traumatic coma. Phenoperidine alone significantly reduced mean arterial pressure (MAP) by a mean (+/- SEM) of 13.2 (+/- 2.8) mm Hg. Overall there was no significant change i...

journal_title：British journal of anaesthesia

authors： Bingham RM,Hinds CJ

更新日期：1987-05-01 00:00:00

abstract：:This editorial looks at some of the various anesthesias used during pregnancy termination. Trichloroethylene, often a popular substitute for halothane, has been subjected to little evaluation. Only clinical study however, can actually establish the significance of myometrial depressant properties in the pregnant pat...

journal_title：British journal of anaesthesia

authors： Grant IS

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS:PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes...

journal_title：British journal of anaesthesia

authors： Ing C,Jackson WM,Zaccariello MJ,Goldberg TE,McCann ME,Grobler A,Davidson A,Sun L,Li G,Warner DO

更新日期：2021-02-01 00:00:00

abstract：:The effect of the administration of propranolol 0.15 mg per kg body weight i.v. on the metabolic response to pelvic surgery was compared with results in similar patients who had not received propranolol. The only significant difference between the two groups was a lower plasma insulin concentration in the beta-blockad...

journal_title：British journal of anaesthesia

authors： Cooper GM,Paterson JL,Mashiter K,Hall GM

更新日期：1980-12-01 00:00:00

abstract：:We studied 20 patients undergoing thoracotomy, in a double-blind, placebo-controlled crossover trial of intercostal bupivacaine. Bupivacaine 0.25% was infused at 5 ml h-1 through each of two catheters placed in the intercostal space at operation. Mean (95% confidence limits) 24-h requirements for morphine from a patie...

journal_title：British journal of anaesthesia

authors： Dryden CM,McMenemin I,Duthie DJ

更新日期：1993-05-01 00:00:00

abstract：:The problems of selection of tracheal tubes, and the need for a rationale, are outlined. Tracheal tubes of 7.5 mm and 8.5 mm i.d. are recommended for female and male patients, respectively. Tracheal size was determined using high pressure-low volume cuffs as measuring devices. The average diameter of the cuff at seal ...

journal_title：British journal of anaesthesia

authors： Chandler M,Crawley BE

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR). METHODS:Male New Zealand White rabbits (n=48) were anaesthetized wi...

journal_title：British journal of anaesthesia

authors： Andrews DT,Royse AG,Royse CF

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:We investigated the extent and frequency of dose errors and treatment delays made as a consequence of preparing drug infusions at the bedside, rather than using pre-filled syringes. METHODS:Forty-eight nurses with critical care experience volunteered to take part in this randomized, blinded, controlled stud...

journal_title：British journal of anaesthesia

authors： Adapa RM,Mani V,Murray LJ,Degnan BA,Ercole A,Cadman B,Williams CE,Gupta AK,Wheeler DW

更新日期：2012-11-01 00:00:00

abstract：:The majority of patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation. This support provides time for the lungs to heal, but the adverse effects of mechanical ventilation significantly influence patient outcome. Traditionally, these were ascribed to mechanical effects, such as haemody...

journal_title：British journal of anaesthesia

authors： Moloney ED,Griffiths MJ

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Emotional information has the ability to alter the formation and strength of a memory ('memory modulation'). Memory modulation by negative emotion is mediated by the amygdala. It is not known how gamma aminobutyric acid (GABA)ergic drugs affect the processes involved in memory modulation. This study investig...

journal_title：British journal of anaesthesia

authors： Pryor KO,Veselis RA,Reinsel RA,Feshchenko VA

更新日期：2004-09-01 00:00:00

abstract：:Using human nasal cytological brushings, we have investigated the effects of morphine on ciliary function by measurement of cilia beat frequency in vitro, and we have also determined opioid receptor binding in these specimens. We obtained ciliated samples from seven volunteers, and measured cilia beat frequency using ...

journal_title：British journal of anaesthesia

authors： Selwyn DA,Raphael JH,Lambert DG,Langton JA

更新日期：1996-02-01 00:00:00

abstract：:It is generally accepted that halothane reduces airway and tissue resistance in lungs with preexisting airway tone. However, under conditions of resting airway tone, pulmonary resistance remains unaltered. In this study, we have determined the effects of halothane on respiratory system, pulmonary and chest wall resist...

journal_title：British journal of anaesthesia

authors： Reta GS,Riva JA,Piriz H,Medeiros AS,Rocco PR,Zin WA

更新日期：2000-03-01 00:00:00

abstract：:Standard methods for accurate intraoperative measurement of neuromuscular block are either expensive or inconvenient and are not used widely. We have evaluated a new method of monitoring neuromuscular block using a low-frequency microphone. The method is based on the phenomenon of low-frequency sound emission by contr...

journal_title：British journal of anaesthesia

authors： Dascalu A,Geller E,Moalem Y,Manoah M,Enav S,Rudick Z

更新日期：1999-09-01 00:00:00

abstract：:The pharmacokinetics of edrophonium were determined in patients anaesthetized with nitrous oxide and halothane undergoing kidney transplant nephrectomy (n=6) or transplantation of a live related donor kidney (n = 6). Serum concentrations of edrophonium were assayed by high pressure liquid chromatography and pharmacoki...

journal_title：British journal of anaesthesia

authors： Morris RB,Cronnelly R,Miller RD,Stanski DR,Fahey MR

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Better education of clinicians is expected to enhance patient safety. An important component of education is adherence to standard protocols, which are mainly available in written form. Believing in the potential power of videos, we hypothesized that the introduction of an educational video, based on an inst...

journal_title：British journal of anaesthesia

authors： Kandler L,Tscholl DW,Kolbe M,Seifert B,Spahn DR,Noethiger CB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Assessments of labour pain focus on pain intensity, not on duration. We aimed to assess the importance labouring women apply to pain intensity and duration before labour and post-delivery. METHODS:Forty healthy women scheduled for labour induction were enrolled in this institutional review board-approved, p...

journal_title：British journal of anaesthesia

authors： Carvalho B,Hilton G,Wen L,Weiniger CF

更新日期：2014-09-01 00:00:00