Abstract：
:We have used mivacurium in four myasthenic patients presenting for thymectomy. Supramaximal single twitch stimulation was applied to the ulnar nerve at the wrist and the force of contraction of the adductor pollicis was measured. After an initial bolus dose of 30 micrograms kg-1 (approximately one-fifth of the normal intubating dose), we observed a mean 37.5 (SEM 5.6)% reduction in evoked twitch tension. Neuromuscular block was increased with incremental doses and maintained with repeat bolus doses of 15 micrograms kg-1 at 25% recovery. The interval between maintenance bolus doses remained constant (mean 5.9 (0.7) min). Spontaneous offset was rapid with a mean recovery index (T25-T75) of 11.9 (2.1) min. Provided anticholinesterase therapy is withheld in the immediate preoperative period, mivacurium would appear to be a safe and appropriate neuromuscular blocker in this variably sensitive group of patients. The cumulative dose required to establish full neuromuscular block varied between 60 and 90 micrograms kg-1. A maintenance infusion, commencing at 3 micrograms kg-1 min-1, is recommended, guided by neuromuscular monitoring.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Paterson IG,Hood JR,Russell SH,Weston MD,Hirsch NPdoi
10.1093/bja/73.4.494subject
Has Abstractpub_date
1994-10-01 00:00:00pages
494-8issue
4eissn
0007-0912issn
1471-6771pii
S0007-0912(17)41753-3journal_volume
73pub_type
杂志文章abstract：:Magnesium inhibits the release of acetylcholine from the motor nerve terminal and thus potentiates the action of the non-depolarizing neuromuscular blocking drugs. We have examined the possibility that this effect might enhance the speed of onset of non-depolarizing block with pancuronium. Following the administration...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/66.2.247
更新日期：1991-02-01 00:00:00
abstract：:We have examined the effects of sedation with midazolam 0.1 mg kg-1 and reversal with flumazenil 0.5 mg on beat-to-beat heart rate (HR) variability (HRV), systolic arterial pressure (SAP), finger photoplethysmograph amplitude (PLA) and impedence pneumography in eight volunteers. With the onset of sedation there was a ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.4.503
更新日期：1996-04-01 00:00:00
abstract：:We studied the interactive effect of dexmedetomidine and morphine on gastric emptying and gastrointestinal transit in the rat. In one group of rats, to examine the interactive effect on gastrointestinal transit, the two drugs were injected i.p. in a fixed ratio (30: 1)--that of their ED50 values--in six doses (0.062-1...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/80.1.63
更新日期：1998-01-01 00:00:00
abstract：:We studied the interaction between paracetamol (acetaminophen U.S.P.) and enflurane. Sixteen rats were assigned to four groups (n = 4) to receive: paracetamol 7.5 mg/100 g body weight; paracetamol plus 1% enflurane; 1% enflurane alone, or no treatment (controls). Animals were killed 6 h later. A second series of 16 we...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.4.429
更新日期：1989-04-01 00:00:00
abstract：:The pharmacokinetics of edrophonium were determined in patients anaesthetized with nitrous oxide and halothane undergoing kidney transplant nephrectomy (n=6) or transplantation of a live related donor kidney (n = 6). Serum concentrations of edrophonium were assayed by high pressure liquid chromatography and pharmacoki...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.12.1311
更新日期：1981-12-01 00:00:00
abstract：:A retrospective study was carried out to determine analgesic requirements in a group of orthopaedic outpatients (n = 145) and oral surgery inpatients (n = 172). The orthopaedic patients received a codeine-paracetamol premedication, an opioid during operation, or no analgesic. Less than 50% of the orthopaedic patients ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/64.5.617
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:The influence of changes in body position relevant to neuraxial blockade on the location of the spinal cord and related neural structures has not been fully quantified. Our aim was to determine the changes, if any, that occur in the location of the spinal cord tip [equivalent to the tip of the conus medullar...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aen295
更新日期：2008-12-01 00:00:00
abstract：:We have assessed neuromuscular block electromyographically at the gastrocnemius muscle and compared it with that at the abductor digiti minimi muscle in 60 adult patients undergoing cervical spine surgery under general anaesthesia. All patients were in the prone position. After vecuronium 0.2 mg kg-1, times to onset o...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,收录出版
doi：10.1093/bja/82.3.329
更新日期：1999-03-01 00:00:00
abstract：:Pre- and postjunctional effects of three ethers (enflurane, diethyle ether, and methoxyflurane) and three non-ethers (chloroform, halothane, and trichloroethylene) were studied in the rat phrenic nerve diaphragm preparation using standard microelectrode recording techniques. Depression of postjunctional function inclu...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/47.5.533
更新日期：1975-05-01 00:00:00
abstract：:The aim of this study was to find, using modern techniques, any histological differences in muscle biopsies between malignant hyperthermia (MH) susceptible (MHS), MH equivocal (MHE) and MH negative (MHN) patients. On the basis of the European MH contracture test carried out in 83 patients, 23 were shown to be MHS, nin...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/79.3.327
更新日期：1997-09-01 00:00:00
abstract：:A blood-gas study of the respiratory effects of sodium nitroprusside during anaesthesia has shown a marked reduction in PaO2 when the drug was administered. After nitroprusside PaO2 returned to the previous values. It is suggested that the reduction in PaO2 is a result of an increased scatter of ventilation/perfusion ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/47.11.1205
更新日期：1975-11-01 00:00:00
abstract：:Fires and explosions have occurred in the operating theatre for many years. Flammable inhalation anaesthetic agents were responsible for many incidents in the past, but these are no longer available in many countries. Other causes of fires and explosions still exist in the operating theatre and, from time to time, res...
journal_title：British journal of anaesthesia
pub_type： 历史文章,杂志文章
doi：10.1093/bja/73.6.847
更新日期：1994-12-01 00:00:00
abstract：:This study was designed to determine whether dextran, gelatin or hydroxyethyl starch-based colloidal resuscitation fluids (CRF) are inhibitory to T lymphocyte activation and mitogenesis in vitro. Isolated peripheral blood lymphocytes from normal donors were activated with mitogen (PHA) and cultured in up to 50% v:v CR...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/81.2.242
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Plethysmographic variability index (PVI) is an accurate predictor of fluid responsiveness in mechanically ventilated patients. However, the site of measurement of the plethysmographic waveform impacts its morphology and its respiratory variation. The goal of this study was to investigate the ability of PVI t...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aer165
更新日期：2011-09-01 00:00:00
abstract：:We have studied the effects of bilateral ilioinguinal nerve block and wound infiltration with 0.5% bupivacaine on postoperative pain and analgesic requirements in 62 patients undergoing Caesarean section under general anaesthesia. A control group received no local anaesthetic supplementation. Both ilioinguinal block a...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/72.2.229
更新日期：1994-02-01 00:00:00
abstract：:The neuromuscular blocking effect of repeated bolus administration of suxamethonium 1 mg/kg was observed in 10 healthy surgical patients under enflurane-nitrous oxide-oxygen anaesthesia. Tachyphylaxis and slow recovery of the thumb twitch occurred in close dose-relationships with transition of Phase I block to Phase I...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.2.91
更新日期：1976-02-01 00:00:00
abstract：:Two patients are described in whom failure of the Pollard endotracheal tube produced complete respiratory obstruction. Comparisons are made of external diameters, resistance to gas flow and resistance to compression between Pollard tubes and several conventional tubes. It is concluded that the Pollard tube is not sati...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.2.179
更新日期：1977-02-01 00:00:00
abstract：:We have studied the effects of amrinone on left and right ventricular haemodynamics in patients with impaired ventricular performance caused by coronary artery disease. Anaesthesia was achieved with fentanyl, flunitrazepam and pancuronium. After reaching steady state, a bolus dose of amrinone 0.5 mg kg-1 was administe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/72.5.567
更新日期：1994-05-01 00:00:00
abstract：:The interaction of three new non-depolarizing neuromuscular blocking agents--atracurium, vecuronium and Duador--on human red cell acetylcholinesterase (AChE; EC 3.1.1.7) and human plasma butyrylcholinesterase (BuChE; EC 3.1.1.8) was investigated. The binding of these neuromuscular blockers to human plasma proteins (pr...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Day-case anaesthesia requires rapidly eliminated anaesthetics which are relatively expensive. This multinational, multicentre European study assessed the relative costs of propofol or sevoflurane anaesthesia in 211 patients. Anaesthesia was induced and maintained with propofol in group 1, with propofol and sevoflurane...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/bja/83.4.564
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:The safety of performing spinal anaesthesia for both patients and anaesthetists alike in the presence of active infection with the novel coronavirus disease 2019 (COVID-19) is unclear. Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.03.007
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Recent studies have concluded that i.v. dexamethasone can prolong the duration of peripheral nerve blockade. We hypothesized that a 4 mg dose would equally prolong the duration of psoas compartment blocks (PCBs) when compared with 8 mg, and that both doses would prolong the duration when compared with placeb...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bja.2017.11.073
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Transtracheal jet ventilation (TTJV) is recommended in several airway guidelines as a potentially life-saving procedure during the 'Can't Intubate Can't Oxygenate' (CICO) emergency. Some studies have questioned its effectiveness. METHODS:Our goal was to determine the complication rates of TTJV in the CICO e...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aew192
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The perioperative management of two-stage oesophagectomy has not been standardized and the prevailing practice regarding the timing of extubation after the procedure varies. This audit has evaluated the outcome, in particular the respiratory morbidity and mortality, after immediate extubation in patients who...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg091
更新日期：2003-04-01 00:00:00
abstract：:Zomepirac 100 mg and dihydrocodeine 30 mg were compared with placebo in a controlled randomized, double-blind, single-dose postoperative study. Patients continued to receive either zomepirac or dihydrocodeine for pain relief for 5 days at home in a double-blind study, being allowed to titrate the consumption of tablet...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/57.4.412
更新日期：1985-04-01 00:00:00
abstract：Background.:Compromised tissue oxygenation is one of the root causes of dysfunction of various organs and postoperative complications. Oxygenation of different tissue beds may follow different patterns of change during physiological derangement. Methods.:Patients undergoing elective major posterior spine surgery parti...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aex008
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:In regional anaesthesia, there is a risk of direct nerve injury. The purpose of this study was to determine whether the diameter of the applied needle is associated with the magnitude of nerve injury after needle nerve perforation. METHODS:In five anaesthetized pigs, the brachial plexus were exposed bilater...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aep366
更新日期：2010-02-01 00:00:00
abstract：:We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.6.935
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Anaesthetic drugs act at sites within the brain that undergo profound changes during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in the EEG change with age. METHODS:We analysed the EEG in 155 patients aged 18-90 yr who received propofol (n=60) or sevoflurane (n=95) as the ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aev213
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The ProSeal laryngeal mask airway (PLMA) is a new laryngeal mask device with a modified cuff and a drainage tube. METHODS:We assessed the PLMA in 300 anaesthetized adults either paralysed or breathing spontaneously. We assessed insertion characteristics, airway seal pressures, haemodynamic response to inser...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/88.4.534
更新日期：2002-04-01 00:00:00
