当前位置： SCI文献检索 > BRITISH JOURNAL OF ANAESTHESIA期刊下所有文献 > Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation.

Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation.

Abstract：

BACKGROUND:The second gas effect (SGE) is considered to be significant only during periods of large volume N(2)O uptake (VN(2)O); however, the SGE of small VN(2)O has not been studied. We hypothesized that the SGE of N(2)O on sevoflurane would become less pronounced when sevoflurane administration is started 60 min after the start of N(2)O administration when VN(2)O has decreased to approximately 125 ml min(-1), and that the kinetics of sevoflurane under these circumstances would become indistinguishable from those when sevoflurane is administered in O(2). METHODS:Seventy-two physical status ASA I-II patients were randomly assigned to one of six groups (n=12 each). In the first four groups, sevoflurane (1.8% vaporizer setting) administration was started 0, 2, 5 and 60 min after starting 2 litre min(-1) O(2) and 4 litre min(-1) N(2)O, respectively. In the last two groups, sevoflurane (1.8 or 3.6% vaporizer setting) was administered in 6 litre min(-1) O(2). The ratios of the alveolar fraction of sevoflurane (Fa) over the inspired fraction (Fi), or Fa/Fi, were compared between the groups. RESULTS:Sevoflurane Fa/Fi was larger in the N(2)O groups than in the O(2) groups, and it was identical in all four N(2)O groups. CONCLUSIONS:We confirmed the existence of a SGE of N(2)O. Surprisingly, when using an Fa of 65% N(2)O, the magnitude of the SGE was the same with large or small VN(2)O. The classical model and the graphical representation of the SGE alone should not be used to explain the magnitude of the SGE. We speculate that changes in ventilation/perfusion inhomogeneity in the lungs during general anaesthesia result in a SGE at levels of VN(2)O previously considered by most to be too small to exert a SGE.

journal_name

Br J Anaesth

journal_title

British journal of anaesthesia

authors

Hendrickx JF,Carette R,Lemmens HJ,De Wolf AM

doi

10.1093/bja/ael008

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

391-5

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)35214-5

journal_volume

96

pub_type

杂志文章,随机对照试验

相关文献

BRITISH JOURNAL OF ANAESTHESIA文献大全
  • Induction dose-response of propofol in unpremedicated children.

    abstract：:The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/68.1.64

    authors： Aun CS,Short SM,Leung DH,Oh TE

    更新日期：1992-01-01 00:00:00

  • Gaseous homeostasis and the circle system. Factors influencing anaesthetic gas exchange.

    abstract：:A mathematical model of a subject breathing from a circle system has been used to follow the course of anaesthetic uptake during the simulated administration of 60% nitrous oxide, 2% halothane and 2% methoxyflurane, under non-rebreathing conditions and with fresh gas flows to the circle system of between 8 and 0.25 li...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/58.10.1167

    authors： Conway CM

    更新日期：1986-10-01 00:00:00

  • Posture used by anaesthetists during laryngoscopy.

    abstract：BACKGROUND:There is little advice on the posture to be used when intubating the trachea. Does the stance used depend on experience? METHODS:Twenty-six subjects with varying experience of intubation were photographed during laryngoscopy of an intubation training mannequin. Posture was measured from the photographs and ...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：

    authors： Walker JD

    更新日期：2002-11-01 00:00:00

  • Intra-vas deferens bupivacaine for prevention of acute pain and chronic discomfort after vasectomy.

    abstract：:We have studied the use of intra-vas deferens local anaesthesia in 70 patients undergoing vasectomy as day-case patients. Patients were allocated randomly to either a control or treatment group. In the treatment group, 0.5% bupivacaine 1 ml or 0.9% saline 1 ml was injected into the lumen of the right or left vas defer...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/74.5.612

    authors： Paxton LD,Huss BK,Loughlin V,Mirakhur RK

    更新日期：1995-05-01 00:00:00

  • The suppressive effect of halothane on DNA synthesis of immunocytes.

    abstract：:Mice, previously immunized with sheep erythrocytes, were anaesthetized with halothane and the splenic lymphoid cells were incubated with 3H-thymidine at 1-h intervals. Abiphasic response was observed; 0.9 and 1.5% halothane reduced 3H-thymidine incorporation into the primed lymphoid cells by 83 and 94% respectively, w...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/48.12.1129

    authors： Bandoh T,Fujita T

    更新日期：1976-12-01 00:00:00

  • Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow.

    abstract：BACKGROUND:Ischaemia is one of the causative mechanisms of peripheral nerve injury, a documented complication of regional anaesthesia. Local anaesthetics per se and/or vasopressor adjuvants may account for changes in peripheral nerve blood flow. The aim of this study was to test the effects of levobupivacaine and ropiv...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aei242

    authors： Bouaziz H,Iohom G,Estèbe JP,Campana WM,Myers RR

    更新日期：2005-11-01 00:00:00

  • Prediction of fluid responsiveness in patients during cardiac surgery.

    abstract：BACKGROUND:Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes. METHODS:Fourteen patients were studied immediately after coronary a...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aeh280

    authors： Rex S,Brose S,Metzelder S,Hüneke R,Schälte G,Autschbach R,Rossaint R,Buhre W

    更新日期：2004-12-01 00:00:00

  • Relationship between severe obesity and depth to the cricothyroid membrane in third-trimester non-labouring parturients: a prospective observational study.

    abstract：BACKGROUND:Severely obese parturients have increased 'cannot intubate, cannot oxygenate' risk during Caesarean section under general anaesthesia. Front-of-neck access (FONA) at the cricothyroid membrane (CTM) is definitive management; however, attempted FONA can fail. Point-of-care ultrasonography may provide useful in...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1016/j.bja.2018.02.010

    authors： Gadd K,Wills K,Harle R,Terblanche N

    更新日期：2018-05-01 00:00:00

  • Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients.

    abstract：BACKGROUND:Postoperative delirium and cognitive decline are common in elderly surgical patients after non-cardiac surgery. Despite this prevalence and clinical importance, no specific aetiological factor has been identified for postoperative delirium and cognitive decline. In experimental setting in a rat model, nitrou...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/bja/ael106

    authors： Leung JM,Sands LP,Vaurio LE,Wang Y

    更新日期：2006-06-01 00:00:00

  • Recovery and skills related to driving after intravenous sedation: dose-response relationship with diazepam.

    abstract：:Skills related to driving, the ability to discriminate the fusion of flickering light, and hand and foot proprioception, were measured double-blind in 34 healthy volunteers before and after three doses of i.v. diazepam. The effects of diazepam were most harmful to co-ordination. With 0.15 mg/kg, 0.30 mg/kg and 0.45 mg...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章

    doi：10.1093/bja/47.4.457

    authors： Korttila K,Linnoila M

    更新日期：1975-04-01 00:00:00

  • A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

    abstract：:The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy volunteers. No significant change in the ventilatory response to rebreathing carbon dioxide was observed after meptazin...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/51.6.497

    authors： Jordan C,Lehane JR,Robson PJ,Jones JG

    更新日期：1979-06-01 00:00:00

  • Blood-gas changes during induced hypotension with sodium nitroprusside.

    abstract：:A blood-gas study of the respiratory effects of sodium nitroprusside during anaesthesia has shown a marked reduction in PaO2 when the drug was administered. After nitroprusside PaO2 returned to the previous values. It is suggested that the reduction in PaO2 is a result of an increased scatter of ventilation/perfusion ...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章

    doi：10.1093/bja/47.11.1205

    authors： Wildsmith JA,Drummond GB,MacRae WR

    更新日期：1975-11-01 00:00:00

  • Pulmonary embolism during surgery for a Wilms' tumour (nephroblastoma). Case report.

    abstract：:During resection of a Wilms' tumour in a 10-year-old girl, sudden bradycardia, hypotension and cyanosis developed, leading to cardiac arrest. It was thought that part of the tumour had caused a pulmonary embolus. After prompt resuscitation, cardiopulmonary bypass surgery was started within 20 min. At operation the lef...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/53.8.903

    authors： Akyön MG,Arslan G

    更新日期：1981-08-01 00:00:00

  • Differential nitric oxide synthase activity, cofactor availability and cGMP accumulation in the central nervous system during anaesthesia.

    abstract：:We investigated the effects of anaesthesia on dynamic nitric oxide production, concentrations of tetrahydrobiopterin and the accumulation of cyclic GMP (cGMP) in the rat central nervous system (CNS). Rats were assigned to anaesthesia with halothane, isoflurane, pentobarbital, diazepam, ketamine or xenon (n=6 per group...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/86.3.388

    authors： Galley HF,Le Cras AE,Logan SD,Webster NR

    更新日期：2001-03-01 00:00:00

  • Priming and the onset of neuromuscular blockade with alcuronium.

    abstract：:"Priming" with alcuronium has been studied in 72 female patients. Blockade of single twitch responses of the adductor pollicis by alcuronium 0.15, 0.2 or 0.3 mg kg-1 could be accelerated by priming with a suitable priming portion of the total dose. Giving alcuronium 0.04 mg kg-1 30 s after the induction of anaesthesia...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/58.8.827

    authors： Black AM,Hutton P,el-Hassan KM,Morgan G,Clutton-Brock TH

    更新日期：1986-08-01 00:00:00

  • Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia.

    abstract：BACKGROUND:Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam. METHODS:After ethics committee approval and consent, 40 adult patients undergoing s...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/aei040

    authors： Bulach R,Myles PS,Russnak M

    更新日期：2005-03-01 00:00:00

  • Mortality analysis in hip fracture patients: implications for design of future outcome trials.

    abstract：INTRODUCTION:Patients with hip fractures are usually frail and elderly with a 30-day mortality in excess of 10% in European series. Perioperative morbidity is often multifactorial in nature, and unimodal interventions will not necessarily decrease mortality. The purpose of this prospective study was to analyse causes o...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aei010

    authors： Foss NB,Kehlet H

    更新日期：2005-01-01 00:00:00

  • Lobectomy for cavitating lung abscess with haemoptysis: strategy for protecting the contralateral lung and also the non-involved lobe of the ipsilateral lung.

    abstract：:We describe the anaesthetic management of a patient undergoing lobectomy for cavitating lung abscess complicated by haemoptysis. Surgery for lung abscess is one of the absolute indications for the use of a double-lumen tube (DLT). Because pus or blood could impede fibreoptic-assisted DLT placement, a traditional, blin...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/85.5.791

    authors： Pfitzner J,Peacock MJ,Tsirgiotis E,Walkley IH

    更新日期：2000-11-01 00:00:00

  • Feedback system to estimate the quality of outpatient preoperative evaluation records: an analysis of end-user satisfaction.

    abstract：BACKGROUND:During preanaesthesia evaluation at an outpatient clinic, information is summarized and structured. We aimed to estimate the effectiveness of this process by determining the proportion of patients presenting for surgery who had valid preoperative anaesthesia assessment records, and also the proportion of pat...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aeq200

    authors： van Klei WA,Peelen LM,Kruijswijk JE,van Wolfswinkel L

    更新日期：2010-11-01 00:00:00

  • Effect of baricity on spinal anaesthesia with amethocaine.

    abstract：:Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/52.6.589

    authors： Brown DT,Wildsmith JA,Covino BG,Scott DB

    更新日期：1980-06-01 00:00:00

  • Effect of clonidine on gastric emptying of liquids.

    abstract：:We have investigated the effects of clonidine on gastric emptying of liquids in 30 patients. In a double-blind, randomized design, clonidine 150 micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later, the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous blood samples were obtaine...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/78.1.28

    authors： Asai T,McBeth C,Stewart JI,Williams J,Vaughan RS,Power I

    更新日期：1997-01-01 00:00:00

  • Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.

    abstract：BACKGROUND:Sepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and oxidative stress. We investigated the effects of treatment with antioxidants that protect mitochondria (MitoQ, MitoE, or melatonin) in a rat model of lipop...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aes577

    authors： Lowes DA,Webster NR,Murphy MP,Galley HF

    更新日期：2013-03-01 00:00:00

  • Frailty assessment: from clinical to radiological tools.

    abstract：:Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve pr...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章,评审

    doi：10.1016/j.bja.2019.03.034

    authors： Bentov I,Kaplan SJ,Pham TN,Reed MJ

    更新日期：2019-07-01 00:00:00

  • Performance of proportional and continuous nitric oxide delivery systems during pressure- and volume-controlled ventilation.

    abstract：:We have evaluated the effect of delivering nitric oxide using a continuous flow system (CFS) or two commercially available proportional gas injection systems (PGIS), Nodomo (Dräger, Lübeck, Germany) and Pulmonox-Mini (Messer Griesheim Austria, Gumpoldskirchen, Austria) on measured and simulated concentrations of nitri...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/81.4.544

    authors： Hiesmayr MJ,Neugebauer T,Lassnigg A,Steltzer H,Haider W,Gilly H

    更新日期：1998-10-01 00:00:00

  • Assessing the pathogenicity of RYR1 variants in malignant hyperthermia.

    abstract：Background:. Missense variants in the ryanodine receptor 1 gene ( RYR1 ) are associated with malignant hyperthermia but only a minority of these have met the criteria for use in predictive DNA diagnosis. We examined the utility of a simplified method of segregation analysis and a functional assay for determining the pa...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aex042

    authors： Merritt A,Booms P,Shaw MA,Miller DM,Daly C,Bilmen JG,Stowell KM,Allen PD,Steele DS,Hopkins PM

    更新日期：2017-04-01 00:00:00

  • Isoflurane impairs odour discrimination learning in rats: differential effects on short- and long-term memory.

    abstract：BACKGROUND:Anaesthetics suppress the formation of lasting memories at concentrations that do not suppress perception, but it is unclear which elements of the complex cascade leading from a conscious experience to a lasting memory trace are disrupted. Experiments in conscious humans suggest that subhypnotic concentratio...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aer451

    authors： Pearce RA,Duscher P,Van Dyke K,Lee M,Andrei AC,Perouansky M

    更新日期：2012-04-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.

    abstract：:In a randomized, double-blind study, we have examined the stereoselective disposition and pharmacodynamic characteristics of ketamine in surgical patients after i.v. administration of S(+)-ketamine 1 mg/kg body weight (25 patients) or racemic ketamine 2 mg/kg body weight (25 patients). S(+)-Ketamine was not inverted t...

    journal_title：British journal of anaesthesia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/bja/70.6.666

    authors： Geisslinger G,Hering W,Thomann P,Knoll R,Kamp HD,Brune K

    更新日期：1993-06-01 00:00:00

  • Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo.

    abstract：:By analysing the EEG, reticular multi-unit activity and behavioural changes, we have classified general anaesthetics into three groups: central nervous system (CNS) depressant, CNS excitant and epileptogenic agents. Changes in CNS neural activity are associated with alteration in transmitter release. We have attempted...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/80.3.365

    authors： Shichino T,Murakawa M,Adachi T,Arai T,Miyazaki Y,Mori K

    更新日期：1998-03-01 00:00:00

  • Influence of the site of measurement on the ability of plethysmographic variability index to predict fluid responsiveness.

    abstract：BACKGROUND:Plethysmographic variability index (PVI) is an accurate predictor of fluid responsiveness in mechanically ventilated patients. However, the site of measurement of the plethysmographic waveform impacts its morphology and its respiratory variation. The goal of this study was to investigate the ability of PVI t...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/aer165

    authors： Desgranges FP,Desebbe O,Ghazouani A,Gilbert K,Keller G,Chiari P,Robin J,Bastien O,Lehot JJ,Cannesson M

    更新日期：2011-09-01 00:00:00

  • Selective depression by alfentanil of group III and IV somatosympathetic reflexes in the dog.

    abstract：:The effect of alfentanil on sympathetic reflexes evoked by supramaximal electrical stimulation of the radial nerve has been observed in five dogs anaesthetized with alpha-chloralose, paralysed with suxamethonium and artificially ventilated. In five dogs during the infusion of alfentanil at a rate of 20 micrograms kg-1...

    journal_title：British journal of anaesthesia

    pub_type： 杂志文章

    doi：10.1093/bja/61.4.441

    authors： Swenzen GO,Chakrabarti MK,Sapsed-Byrne S,Whitwam JG

    更新日期：1988-10-01 00:00:00