Effect of clonidine on gastric emptying of liquids.

Abstract:

:We have investigated the effects of clonidine on gastric emptying of liquids in 30 patients. In a double-blind, randomized design, clonidine 150 micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later, the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous blood samples were obtained every 15 min for 90 min thereafter. Plasma paracetamol concentrations were measured using high-pressure liquid chromatography and the area under the concentration-time curve was calculated. The degree of sedation and complications were recorded. The area under the curve for 0-60 min was significantly smaller in the morphine group than in the saline group (P = 0.002; 95% confidence interval (CI) for difference -1237 to -502 micrograms min ml-1), whereas it was greater in the clonidine group compared with the saline group, although this was not significant (95% CI for difference -423 to 1264 micrograms min ml-1). Arterial pressure was significantly lower in the clonidine group compared with the saline group. Both clonidine and morphine appeared to cause mild sedation. We conclude that clonidine 150 micrograms i.m. does not delay gastric emptying of liquids in a similar manner to morphine.

journal_name

Br J Anaesth

authors

Asai T,McBeth C,Stewart JI,Williams J,Vaughan RS,Power I

doi

10.1093/bja/78.1.28

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

28-33

issue

1

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)42002-2

journal_volume

78

pub_type

临床试验,杂志文章,随机对照试验
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