Propofol administered by a manual infusion regimen.

Abstract:

:We have evaluated the clinical utility and blood propofol concentrations produced with two different infusion regimens for propofol, given to supplement 67% nitrous oxide-morphine anaesthesia. Patients received a standardized three-step infusion of propofol based either on body weight (weight-corrected group) or on a mean body weight of 70 kg (standard dose group). Both groups showed similar cardiovascular stability and recovery times. In the 48 patients studied, isoflurane was used as a supplement in nine (two in the weight-corrected group). Apparent steady state blood propofol concentrations were 3.41 (SD 0.69) micrograms ml-1 in the weight-corrected group and 3.46 (0.79) microgram ml-1 in the standard dose group. These results suggest that for patients weighing 60-90 kg body weight, a standard dose infusion regimen may be a suitable starting point. In routine clinical practice, the need for isoflurane supplementation may be avoided by subsequent titration of the infusion rate according to clinical response. Computer simulation of the actual infusion rates used in each patient has allowed retrospective comparison of the predictive performance of different pharmacokinetic descriptors for propofol. The variables described by Tackley and colleagues provided a more accurate prediction of the measured blood propofol concentration than did the variable set reported by Gepts and colleagues.

journal_name

Br J Anaesth

authors

Sear JW,Glen JB

doi

10.1093/bja/74.4.362

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

362-7

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)40650-7

journal_volume

74

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Gorven AM,Cooper GM,Prys-Roberts C

    更新日期:1986-03-01 00:00:00

  • Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine.

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    doi:10.1093/bja/aei156

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    更新日期:2005-08-01 00:00:00

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    更新日期:2009-09-01 00:00:00

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    更新日期:1986-03-01 00:00:00

  • Effects of anaesthesia method and tourniquet use on recovery following total knee arthroplasty: a randomised controlled study.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bja.2020.03.036

    authors: Palanne R,Rantasalo M,Vakkuri A,Madanat R,Olkkola KT,Lahtinen K,Reponen E,Linko R,Vahlberg T,Skants N

    更新日期:2020-11-01 00:00:00

  • Haemodynamic effects of diaspirin crosslinked haemoglobin (DCLHb) given before abdominal aortic aneurysm surgery.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/83.5.702

    authors: Garrioch MA,McClure JH,Wildsmith JA

    更新日期:1999-11-01 00:00:00

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    更新日期:1988-10-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aew215

    authors: Harju J,Kalliomäki ML,Leppikangas H,Kiviharju M,Yli-Hankala A

    更新日期:2016-09-01 00:00:00

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    authors: Tremlett MR,Kelly PJ,Parkins J,Hughes D,Redfern N

    更新日期:1999-08-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:1997-06-01 00:00:00

  • Inhibition of mitochondrial respiration by sodium nitroprusside and the mechanism of cyanide liberation.

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    pub_type: 杂志文章

    doi:10.1093/bja/49.12.1239

    authors: Nakamura S,Shin T,Hirokata Y,Shigematsu A

    更新日期:1977-12-01 00:00:00

  • A stochastic basis for neural inertia in emergence from general anaesthesia.

    abstract:BACKGROUND:Transitions into and out of the anaesthetised state exhibit resistance to state transitions known as neural inertia. As a consequence, emergence from anaesthesia occurs at a consistently lower anaesthetic concentration than induction. Motivated by stochastic switching between discrete activity patterns obser...

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    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.02.035

    authors: Proekt A,Hudson AE

    更新日期:2018-07-01 00:00:00

  • Regurgitation of gastric contents during general anaesthesia using the laryngeal mask airway.

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    pub_type: 杂志文章

    doi:10.1093/bja/69.3.314

    authors: Barker P,Langton JA,Murphy PJ,Rowbotham DJ

    更新日期:1992-09-01 00:00:00

  • Cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys.

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    pub_type: 杂志文章

    doi:10.1093/bja/48.9.847

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    更新日期:1976-09-01 00:00:00

  • Effects of diazepam and ketamine administered individually or in combination on regional rates of glucose utilization in rat brain.

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    doi:10.1093/bja/82.4.596

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    pub_type: 杂志文章

    doi:10.1093/bja/57.2.204

    authors: Feldt-Rasmussen BF,Gefke K,Mosbech H,Hanel HK

    更新日期:1985-02-01 00:00:00

  • Validity and reliability of a postoperative quality of recovery score: the QoR-40.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.bja.a013366

    authors: Myles PS,Weitkamp B,Jones K,Melick J,Hensen S

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/bja/68.3.318

    authors: Chui PT,Gin T,Chung SC

    更新日期:1992-03-01 00:00:00

  • Enjoying work or burdened by it? How anaesthetists experience and handle difficulties at work: a qualitative study.

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    pub_type: 杂志文章,多中心研究

    doi:10.1093/bja/aem233

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    更新日期:2007-10-01 00:00:00

  • Influence of halothane on the train-of-four fade after atracurium in children.

    abstract::The influence of halothane was studied on train-of-four fade during spontaneous recovery from neuromuscular block produced by atracurium in 42 children undergoing routine surgical procedures under general anaesthesia. The ulnar nerve was stimulated at the wrist, and compound electromyographic responses were recorded f...

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    pub_type: 杂志文章

    doi:10.1093/bja/65.4.540

    authors: Woloszczuk-Gebicka B

    更新日期:1990-10-01 00:00:00

  • Althesin as an induction agent for Caesarean section.

    abstract::Thirty patients for elective lower segment Caesarean section were randomly divided into two groups. One group received 50 mulitre/kg of Althesin for induction of anaesthesia and the other, 100 mulitre/kg. The two maternal groups were similar. There was no significant difference in the clinical or biochemical status of...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/47.11.1213

    authors: Holdcroft A,Morgan M,Gordon H,Whitwam JG,White Y

    更新日期:1975-11-01 00:00:00

  • Comparison of Alaris AEP index and bispectral index during propofol-remifentanil anaesthesia.

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    pub_type: 杂志文章

    doi:10.1093/bja/aeg189

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    更新日期:2003-09-01 00:00:00

  • Continuous flow ventilation without respiratory movement in cat, dog and human.

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    pub_type: 杂志文章

    doi:10.1093/bja/58.5.544

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  • Suxamethonium-induced hyperkalaemia in patients with severe intra-abdominal infections.

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    doi:10.1093/bja/48.6.557

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    pub_type: 杂志文章

    doi:10.1093/bja/51.11.1007

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    更新日期:1979-11-01 00:00:00

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    更新日期:1999-01-01 00:00:00