Effect of a mixture of pyridostigmine and atropine on forced expiratory volume (FEV1), and serum cholinesterase activity in normal subjects.

Abstract:

:Pyridostigmine 0.143 mg kg-1 (maximum 10 mg) and atropine 0.0143 mg kg-1 (maximum 1 mg) were administered i.v. to six healthy male volunteers. Peripheral venous blood samples were drawn for measurement of serum cholinesterase activity. Maximum inhibition of the enzyme was found 5 min after injection with a decrease to 27 +/- 5% (mean +/- SEM) of the original activity. Forced expiratory volume in the first 1s (FEV1) was measured at fixed time intervals for 90 min. No decrease in FEV1 was observed; on the contrary, there was a small increase. We conclude that atropine effectively antagonizes the muscarinic side-effects of pyridostigmine on bronchial smooth muscle tone and bronchial secretions, when administered in clinical doses to normal human subjects.

journal_name

Br J Anaesth

authors

Feldt-Rasmussen BF,Gefke K,Mosbech H,Hanel HK

doi

10.1093/bja/57.2.204

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

204-7

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)41493-0

journal_volume

57

pub_type

杂志文章
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    更新日期:2000-01-01 00:00:00

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  • Incidence of venous gas embolism during robotic-assisted laparoscopic radical prostatectomy is lower than that during radical retropubic prostatectomy.

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    pub_type: 杂志文章

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    更新日期:2010-12-01 00:00:00

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    doi:10.1093/bja/65.4.521

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  • Determination of moderate-to-severe postoperative pain on the numeric rating scale: a cut-off point analysis applying four different methods.

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    pub_type: 杂志文章

    doi:10.1093/bja/aer195

    authors: Gerbershagen HJ,Rothaug J,Kalkman CJ,Meissner W

    更新日期:2011-10-01 00:00:00

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    更新日期:2008-07-01 00:00:00

  • Antagonism of the effects of midazolam on phrenic nerve activity in the dog by Ro 15-1788 and Ro 15-3505.

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    doi:10.1093/bja/aeh199

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    doi:10.1093/bja/80.6.796

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  • Anaesthetics and cardiac preconditioning. Part II. Clinical implications.

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    pub_type: 杂志文章,评审

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    更新日期:2003-10-01 00:00:00

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    doi:10.1093/bja/48.9.847

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    更新日期:1976-09-01 00:00:00

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    更新日期:1978-09-01 00:00:00

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    更新日期:1998-09-01 00:00:00

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