Antagonism of the effects of midazolam on phrenic nerve activity in the dog by Ro 15-1788 and Ro 15-3505.

abstract：BACKGROUND:In critically ill children, monitoring of cardiac output (CO) is essential to guide haemodynamic management and facilitate cardiovascular therapy. The ultrasound dilution technique (UDT), a novel minimally invasive indicator method, was recently introduced to determine CO. We validated UDT against the 'gold ...

journal_title：British journal of anaesthesia

authors： Boehne M,Baustert M,Paetzel V,Köditz H,Schoof S,Happel CM,Bertram H

更新日期：2014-03-01 00:00:00

abstract：:An oxygen consuming lung model was used for evaluation and validation of a technique for metabolic gas exchange measurements during controlled ventilation. The technique comprised a Servo 900 C ventilator (Siemens) and separate oxygen and carbon dioxide analysers (Beckman). Measurements of oxygen consumption and carbo...

journal_title：British journal of anaesthesia

authors： Svensson KL,Sonander HG,Stenqvist O

更新日期：1990-03-01 00:00:00

abstract：:This editorial looks at some of the various anesthesias used during pregnancy termination. Trichloroethylene, often a popular substitute for halothane, has been subjected to little evaluation. Only clinical study however, can actually establish the significance of myometrial depressant properties in the pregnant pat...

journal_title：British journal of anaesthesia

authors： Grant IS

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Pressures (Pe) exerted by bronchial blockers on the inner wall of the bronchi may cause mucosal ischaemia. Our aims were as follows: (i) to compare the intracuff pressure (Pi) and Pe exerted by commercially available bronchial blockers in an in vitro and an ex vivo model; (ii) to investigate the influence of...

journal_title：British journal of anaesthesia

authors： Carassiti M,Mattei A,Pizzo CM,Vallone N,Saccomandi P,Schena E

更新日期：2016-09-01 00:00:00

abstract：:To assess the usefulness of the Gram stain in the early diagnosis of ventilator-associated pneumonia (VAP), we performed 146 protected specimen brushings (PSB) and bronchoalveolar lavages (BAL) in 118 patients suspected of having nosocomial pneumonia. Gram stain and counts of infected cells were performed in all sampl...

journal_title：British journal of anaesthesia

authors： Allaouchiche B,Jaumain H,Chassard D,Boulétreau P

更新日期：1999-12-01 00:00:00

abstract：:We investigated the effect of incision and sternotomy on the auditory evoked potential (AEP) and EEG, to try to predict a haemodynamic response to incision or sternotomy using the AEP and EEG in 41 patients undergoing cardiac surgery during propofol and alfentanil anaesthesia. The AEP and EEG were recorded before inci...

journal_title：British journal of anaesthesia

authors： de Beer NA,van Hooff JC,Cluitmans PJ,Korsten HH,Grouls RJ

更新日期：1996-05-01 00:00:00

abstract：:Placental blood flow was measured during the first stage of normal labour using a xenon-133 clearance technique before and after segmental extradural analgesia. Analgesia was produced with 0.5% plain bupivacaine in eight patients and with 0.5% bupivacaine--adrenaline in 10 patients. Segmental extradural analgesia with...

journal_title：British journal of anaesthesia

authors： Jouppila R,Jouppila P,Hollmén A,Kuikka J

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:The esCCO monitor (ECG- estimated Continuous Cardiac Output, Nihon Kohden(®)) is a new non-invasive tool for estimating cardiac output (CO). It derives CO from the pulse wave transit time (PWTT) estimated by the ECG and the plethysmographic wave. An initial calibration is needed to refine the relation linkin...

journal_title：British journal of anaesthesia

authors： Bataille B,Bertuit M,Mora M,Mazerolles M,Cocquet P,Masson B,Moussot PE,Ginot J,Silva S,Larché J

更新日期：2012-12-01 00:00:00

abstract：:A combination of exogenous surfactant and partial liquid ventilation (PLV) with perfluorocarbons should enhance gas exchange, improve respiratory mechanics and reduce tissue damage of the lung in acute lung injury (ALI). We used a small dose of exogenous surfactant with and without PLV in an experimental model of ALI ...

journal_title：British journal of anaesthesia

authors： Wolf S,Lohbrunner H,Busch T,Sterner-Kock A,Deja M,Sarrafzadeh A,Neumann U,Kaisers U

更新日期：2001-10-01 00:00:00

abstract：:Recent research has shown that high-frequency, gamma-band electroencephalographic (EEG) oscillations (40-60 Hz) may be an important marker of the conscious state. We compared the ability of the bispectral index (BIS) to distinguish the awake and anaesthetized states during the induction of general anaesthesia with: (i...

journal_title：British journal of anaesthesia

authors： Sleigh JW,Steyn-Ross DA,Steyn-Ross ML,Williams ML,Smith P

更新日期：2001-01-01 00:00:00

abstract：:The influence of sodium nitroprusside (SNP) on mitochondrial respiration was examined in rat liver mitochondria. The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%. A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more mark...

journal_title：British journal of anaesthesia

authors： Nakamura S,Shin T,Hirokata Y,Shigematsu A

更新日期：1977-12-01 00:00:00

abstract：:We have investigated the effects of 9.5% and 14.1% MAC concentrations of isoflurane on some psychometric measurements. Both concentrations depressed peak saccadic velocity (P < 0.01), choice reaction time (P < 0.05) and visual analogue scores for sedation (P < 0.05), but not the critical flicker fusion threshold. The ...

journal_title：British journal of anaesthesia

authors： Yoshizumi J,Marshall RW,Sanders LD,Vickers MD

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:To study adequate antinociception during general anaesthesia, tetanic stimulus of 5-10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of ...

journal_title：British journal of anaesthesia

authors： Rantanen M,Yppärilä-Wolters H,van Gils M,Yli-Hankala A,Huiku M,Kymäläinen M,Korhonen I

更新日期：2007-10-01 00:00:00

abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...

journal_title：British journal of anaesthesia

authors： Clarke TN,Foëx P,Roberts JG,Saner CA,Bennett MJ

更新日期：1980-03-01 00:00:00

abstract：:This study was designed to investigate if propofol produced cardiovascular effects by direct actions or by indirect actions secondary to depression of the central nervous system. Experiments were performed on chloralose anaesthetized dogs in which all neurogenic cardiovascular reflexes were abolished by bilateral vago...

journal_title：British journal of anaesthesia

authors： Goodchild CS,Serrao JM

更新日期：1989-07-01 00:00:00

abstract：:Tissue damage during surgery induces coagulation factors and activates platelets. Surgical pain may provoke release of catecholamines, leading to hypercoagulability. We have investigated the effect of surgical pain on blood coagulability and fibrinolysis in orthopaedic operations using tourniquets in 22 patients under...

journal_title：British journal of anaesthesia

authors： Kohro S,Yamakage M,Arakawa J,Kotaki M,Omote T,Namiki A

更新日期：1998-04-01 00:00:00

abstract：:Intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. Sympathetic function was u...

journal_title：British journal of anaesthesia

authors： Hughes R,Chapple DJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Muscle relaxants facilitate tracheal intubation, but they are often not used for short peripheral surgical procedures. The consequences of this practice on the upper airway are still a matter of controversy. We therefore compared the incidence of post-intubation symptoms in a randomized study comparing patie...

journal_title：British journal of anaesthesia

authors： Combes X,Andriamifidy L,Dufresne E,Suen P,Sauvat S,Scherrer E,Feiss P,Marty J,Duvaldestin P

更新日期：2007-08-01 00:00:00

abstract：:Ketamine, as the sole anaesthetic agent, was assessed in a double-blind study of 135 female patients who underwent laparoscopic sterilization. The patients were allocated randomly to one of four groups according to the type (pentobarbitone or droperidol) and route (i.v. or i.m.) of premedication. In addition all the p...

journal_title：British journal of anaesthesia

authors： Figallo EM,Casali H,McKenzie R,Tantisira B,Wadhwa RK,Taylor FH

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Treprostinil sodium improves haemodynamics and symptoms in pulmonary arterial hypertension (PAH) patients, but its subcutaneous (s.c.) administration can produce severe local site pain, and lead to discontinuation of vital treatment. Treprostinil is a prostacyclin analogue which stimulates prostacyclin recep...

journal_title：British journal of anaesthesia

authors： Libri V,Gibbs JS,Pinato DJ,Iddamalgoda T,Khengar RH,Gin-Sing W,Huson L,Anand P

更新日期：2014-02-01 00:00:00

abstract：:A technique of induction of anaesthesia using propanidid, lignocaine and suxamethonium is described, and the muscle fasciculations that follow it are shown to be significantly less than those accompanying induction with methohexitone and suxamethonium. ...

journal_title：British journal of anaesthesia

authors： Fry EN

更新日期：1975-06-01 00:00:00

abstract：:We have investigated the effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy. At the end of surgery, an interpleural catheter was inserted in 17 patients and, in a double-blind and randomized manner, either a bolus of morphine 2.5 mg interpleurally (i.p.) and normal saline i....

journal_title：British journal of anaesthesia

authors： Welte M,Haimerl E,Groh J,Briegel J,Sunder-Plassmann L,Herz A,Peter K,Stein C

更新日期：1992-12-01 00:00:00

abstract：:The cardiorespiratory effects of increasing respiratory frequency were investigated in two groups of dogs ventilated mechanically with a system which minimized apparatus and anatomical deadspace. In one group minute volume was constant whilst frequency was increased; in the second group minute volume was increased to ...

journal_title：British journal of anaesthesia

authors： Chakrabarti MK,Sykes MK

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Patients undergoing non-cardiac, non-vascular surgery are at risk of major cardiovascular complications. In non-cardiac surgery, troponin elevation has previously been shown to be an independent predictor of major adverse cardiac events and postoperative mortality; however, a majority of studies have focused...

journal_title：British journal of anaesthesia

authors： Ekeloef S,Alamili M,Devereaux PJ,Gögenur I

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Previous national survey research has shown significant deficits in routine postoperative pain management in the UK. This study used an organizational change perspective to explore in detail the organizational challenges faced by three acute pain services in improving postoperative pain management. METHODS:...

journal_title：British journal of anaesthesia

authors： Powell AE,Davies HT,Bannister J,Macrae WA

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS:One hundred and twenty subjects were randomly alloca...

journal_title：British journal of anaesthesia

authors： Harsten A,Kehlet H,Toksvig-Larsen S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:One-lung ventilation (OLV) increases mechanical stress in the lung and affects ventilation and perfusion (V, Q). There are no data on the effects of OLV on postoperative V/Q matching. Thus, this controlled study evaluates the influence of OLV on V/Q distribution in a pig model using a gamma camera technique ...

journal_title：British journal of anaesthesia

authors： Kozian A,Schilling T,Fredén F,Maripuu E,Röcken C,Strang C,Hachenberg T,Hedenstierna G

更新日期：2008-04-01 00:00:00

abstract：:In a double-blind, placebo-controlled three-way cross over study, the efficacy of Ro 15-1788 200 mg, a new benzodiazepine antagonist, in blocking the amnesic, cognitive, psychomotor and subjective effects of diazepam 20 mg, was investigated in a group of six healthy male volunteers. The amnesic effects of diazepam wer...

journal_title：British journal of anaesthesia

authors： O'Boyle C,Lambe R,Darragh A,Taffe W,Brick I,Kenny M

更新日期：1983-04-01 00:00:00

abstract：:Before the induction of labour in 34 pregnant women 1.5% lignocaine 10 ml was injected into the lumbar extradural space at constant rates between 0.143 and 0.333 ml s-1. Injection pressures and residual pressures were recorded and the extent of analgesia to pinprick was assessed. No significant correlation was found b...

journal_title：British journal of anaesthesia

authors： Husemeyer RP,White DC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Inconsistent and poorly coordinated systems of tracheostomy care commonly result in frustrations, delays, and harm. Quality improvement strategies described by exemplar hospitals of the Global Tracheostomy Collaborative have potential to mitigate such problems. This 3 yr guided implementation programme inves...

journal_title：British journal of anaesthesia

authors： McGrath BA,Wallace S,Lynch J,Bonvento B,Coe B,Owen A,Firn M,Brenner MJ,Edwards E,Finch TL,Cameron T,Narula A,Roberson DW

更新日期：2020-07-01 00:00:00