Abstract：
BACKGROUND:Pressures (Pe) exerted by bronchial blockers on the inner wall of the bronchi may cause mucosal ischaemia. Our aims were as follows: (i) to compare the intracuff pressure (Pi) and Pe exerted by commercially available bronchial blockers in an in vitro and an ex vivo model; (ii) to investigate the influence of both the inflated intracuff volume and cuff diameter on Pe; and (iii) to estimate the minimal sealing volume (VSmin) and the corresponding Pe for each bronchial blocker studied. METHODS:The Pe exerted by seven commercial bronchial blockers was measured at different inflation volumes using a custom-designed system using in vitro and ex vivo animal models with two internal diameters (12 and 15 mm). RESULTS:In the same conditions, Pi was significantly lower than Pe (P<0.05), and Pe was higher in the in vitro model than in the ex vivo model. The Pe increased with the inflated volume, with use of the small-diameter model (P<0.05). Ex vivo models needed a higher minimal sealing volume than the in vitro models, and this volume increased with the diameter (e.g. the VSmin at a positive pressure of 25 cm H2O required a Pe ranging from 12 to 78 mm Hg on the 15 mm ex vivo model and from 66 to 110 mm Hg on the 12 mm ex vivo model). CONCLUSIONS:The Pi cannot be used to approximate Pe. The diameter of the model, the inflated volume, and the bronchial blocker design all influence Pe. A pressure higher than the critical ischaemic threshold (i.e. 25 mm Hg) was needed to prevent air leak around the cuff in the in vitro and ex vivo models.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Carassiti M,Mattei A,Pizzo CM,Vallone N,Saccomandi P,Schena Edoi
10.1093/bja/aew120subject
Has Abstractpub_date
2016-09-01 00:00:00pages
i92-i96eissn
0007-0912issn
1471-6771pii
S0007-0912(17)33774-1journal_volume
117 Suppl 1pub_type
杂志文章abstract：:We have investigated the effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy. At the end of surgery, an interpleural catheter was inserted in 17 patients and, in a double-blind and randomized manner, either a bolus of morphine 2.5 mg interpleurally (i.p.) and normal saline i....
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/69.6.637
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abstract：Background:Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing animal brain, including those of non-human primates (NHPs), anaesthetics induce apoptotic cell death. We previously reported that a 5 h isoflurane (ISO...
journal_title：British journal of anaesthesia
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journal_title：British journal of anaesthesia
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更新日期：2017-02-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.3.277
更新日期：1977-03-01 00:00:00
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journal_title：British journal of anaesthesia
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更新日期：2007-06-01 00:00:00
abstract：:We studied 133 women given a combined spinal-epidural for analgesia in labour. The initial intrathecal dose contained bupivacaine 2.5 mg with fentanyl 25 micrograms. When the mothers were comfortable, they were allocated randomly to one of three groups: continuous infusion (group Cl, n = 46), midwife top-ups (group MW...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1990-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bja.2020.12.018
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
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更新日期：1989-02-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.4.389
更新日期：1985-04-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-04-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/51.10.943
更新日期：1979-10-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2007-09-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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doi：10.1093/bja/aem340
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:The analgesic efficacy of continuous transversus abdominis plane (TAP) blocks in comparison with that of single-injection TAP blocks is not clear. This randomized, triple-blind, placebo-controlled trial investigated the benefits of adding continuous TAP blocks to single-injection TAP blocks after a laparotom...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
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journal_title：British journal of anaesthesia
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
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更新日期：1992-10-01 00:00:00
