Pharmacokinetics of fazadinium in patients with renal failure.

abstract：BACKGROUND:The oesophageal leak pressure is defined as the pressure which breaks the seal between the cuff of a supraglottic airway and the peri-cuff mucosa, allowing penetration of fluid into the pharynx and the oral cavity. As a consequence, a decrease in this variable increases the risk of reflux and can lead to pul...

journal_title：British journal of anaesthesia

authors： Hensel M,Schmidbauer W,Geppert D,Sehner S,Bogusch G,Kerner T

更新日期：2016-02-01 00:00:00

abstract：:Intercostal nerve blockade of the 10th, 11th and 12th thoracic nerves on the right side was compared with i.m. papaveretum as analgesia after appendicectomy. Patients with intercostal nerve blockade had significantly less pain at 0, 4, 8 and 12 h after operation and required less papaveretum (mean 0.26 mg kg-1/24 h) c...

journal_title：British journal of anaesthesia

authors： Bunting P,McGeachie JF

更新日期：1988-08-01 00:00:00

abstract：:Acetazolamide, a carbonic anhydrase inhibitor, may cause significant disturbances in carbon dioxide transport and elimination. In this study, end-tidal carbon dioxide monitoring has been used to study the correlation between arterial carbon dioxide (PaCO2) and end-tidal carbon dioxide partial pressure (PE'CO2) in rabb...

journal_title：British journal of anaesthesia

authors： Lee TS

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Risks and costs of allogeneic blood transfusions mandate strategies to reduce blood loss in surgery. The objective of this study was to assess the efficacy of antifibrinolytic treatment in reducing perioperative blood loss during total knee replacement. METHODS:A double-blind, randomized and placebo-control...

journal_title：British journal of anaesthesia

authors： Camarasa MA,Ollé G,Serra-Prat M,Martín A,Sánchez M,Ricós P,Pérez A,Opisso L

更新日期：2006-05-01 00:00:00

abstract：:We report an unusual case of acute upper airway obstruction. Inhalation of a foreign body caused choking in a 5-yr-old child, but subsequent investigations revealed a large anterior mediastinal tumour, externally compressing the trachea and the main bronchi. Such a presentation may be deceptive and is important, as ge...

journal_title：British journal of anaesthesia

authors： Akhtar TM,Ridley S,Best CJ

更新日期：1991-11-01 00:00:00

abstract：:Dysregulation of the immuno-inflammatory response, as seen in sepsis, may culminate in host cell and organ damage. Lipopolysaccharide from Gram-negative bacterial cell walls induces gene activation and subsequent inflammatory mediator expression. Gene activation is regulated by a number of transcription factors at the...

journal_title：British journal of anaesthesia

authors： Macdonald J,Galley HF,Webster NR

更新日期：2003-02-01 00:00:00

abstract：:We have compared insertion of a tracheal tube and laryngeal mask airway (LMA) both with and without the presence of a tube in the oesophagus in 20 ASA I and II patients undergoing elective laparoscopy. After induction of anaesthesia and neuromuscular block, we measured the times for an experienced anaesthetist to corr...

journal_title：British journal of anaesthesia

authors： Pace NA,Gajraj NM,Pennant JH,Victory RA,Johnson ER,White PF

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Serum vascular endothelial growth factor-C (VEGF-C), transforming growth factor-β (TGF-β), and interleukin (IL)-6 promote angiogenesis and metastases in colon cancer. We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-β, and IL-6 and an incre...

journal_title：British journal of anaesthesia

authors： Xu YJ,Chen WK,Zhu Y,Wang SL,Miao CH

更新日期：2014-07-01 00:00:00

abstract：:Seven patients are described in whom a prophylactic blood patch was instituted within 15 min of accidental dural puncture. Five of the patients received extradural anaesthesia before the blood patch, and one after the blood patch had been performed. In three of these patients further "top-up" doses of local anaestheti...

journal_title：British journal of anaesthesia

authors： Quaynor H,Corbey M

更新日期：1985-05-01 00:00:00

abstract：:Mean venous pressures were measured in 20 patients in whom a catheter, inserted via the external jugular vein, failed to pass centrally. The catheter used had a rounded end and two side holes. Pressures were measured with the patient's head in three different positions. The pressures were compared with the central ven...

journal_title：British journal of anaesthesia

authors： Shah MV,Swai EA,Latto IP

更新日期：1986-12-01 00:00:00

abstract：:NHS Blood and Transplant (NHSBT) was established in 2005 as a Special Health Authority when the National Blood Authority and UK Transplant merged. This helped to bring tissue banking and organ transplantation services under one umbrella organization. This merger means that ~!95% of all deceased donors (whether tissue,...

journal_title：British journal of anaesthesia

authors： Gaum L,Reynolds I,Jones MN,Clarkson AJ,Gillan HL,Kaye SB

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cerebral state index (CSI) has recently been introduced as an intra-operative monitor of anaesthetic depth. We compared the performance of the CSI to the bispectral index (BIS) in measuring depth of anaesthesia during target-controlled infusion (TCI) of propofol. METHODS:Twenty Chinese patients undergoing g...

journal_title：British journal of anaesthesia

authors： Zhong T,Guo QL,Pang YD,Peng LF,Li CL

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for...

journal_title：British journal of anaesthesia

authors： Zuppa AF,Nicolson SC,Wilder NS,Ibla JC,Gottlieb EA,Burns KM,Stylianou M,Trachtenberg F,Ni H,Skeen TH,Andropoulos DB,Pediatric Heart Network Investigators.

更新日期：2019-12-01 00:00:00

abstract：:A combination of exogenous surfactant and partial liquid ventilation (PLV) with perfluorocarbons should enhance gas exchange, improve respiratory mechanics and reduce tissue damage of the lung in acute lung injury (ALI). We used a small dose of exogenous surfactant with and without PLV in an experimental model of ALI ...

journal_title：British journal of anaesthesia

authors： Wolf S,Lohbrunner H,Busch T,Sterner-Kock A,Deja M,Sarrafzadeh A,Neumann U,Kaisers U

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Age and diabetes mellitus have been identified as independent risk factors for cognitive decline after cardiac surgery with cardiopulmonary bypass (CPB). We tested the effects of CPB on cognitive function in aged and diabetic rats utilizing the Morris water maze (MWM). METHODS:Aged rats (26 months) were ran...

journal_title：British journal of anaesthesia

authors： de Lange F,Dieleman JM,Jungwirth B,Kalkman CJ

更新日期：2007-08-01 00:00:00

abstract：:We studied a cat model simulating laudanosine accumulation in the "anephric" patient. Cardiovascular effects were seen only with the bolus doses of laudanosine 2 mg kg-1, and at plasma laudanosine concentrations unlikely to be achieved clinically. Similarly, EEG and power spectra analysis showed no evidence of epilept...

journal_title：British journal of anaesthesia

authors： Ingram MD,Sclabassi RJ,Cook DR,Stiller RL,Bennett MH

更新日期：1986-01-01 00:00:00

abstract：:The pharmacokinetics of edrophonium were determined in patients anaesthetized with nitrous oxide and halothane undergoing kidney transplant nephrectomy (n=6) or transplantation of a live related donor kidney (n = 6). Serum concentrations of edrophonium were assayed by high pressure liquid chromatography and pharmacoki...

journal_title：British journal of anaesthesia

authors： Morris RB,Cronnelly R,Miller RD,Stanski DR,Fahey MR

更新日期：1981-12-01 00:00:00

abstract：:A computer-controlled infusion of propofol designed to achieve a target blood concentration of propofol 3 microgram ml-1 was used to investigate the possibility of an interaction between propofol and fentanyl in 32 patients undergoing body surface surgery. In 16 patients who were not receiving a neuromuscular blocker ...

journal_title：British journal of anaesthesia

authors： Dixon J,Roberts FL,Tackley RM,Lewis GT,Connell H,Prys-Roberts C

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Paravertebral regional anaesthesia is used to treat pain after several surgical procedures. This study aimed to improve on our first published ultrasound-guided approach to the paravertebral space (PVS) and to investigate a possible discrepancy between the needle, catheter, and contrast dye position. METHOD...

journal_title：British journal of anaesthesia

authors： Luyet C,Herrmann G,Ross S,Vogt A,Greif R,Moriggl B,Eichenberger U

更新日期：2011-02-01 00:00:00

abstract：:In order to evaluate simple means of determining the rate of recovery after general anaesthesia, the usefulness of the critical flicker fusion threshold test, the Maddox wing apparatus and the visual analogue scale were compared. The postanaesthetic recovery score was used as a reference. Two patient groups (n = 15 in...

journal_title：British journal of anaesthesia

authors： Manner T,Kanto J,Salonen M

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Arterial cannulation is a common anaesthetic procedure that can be challenging and time-consuming in small children. By visualizing the position of the radial artery, near-infrared vascular imaging systems (NIRVISs) might be of assistance in arterial cannulation. The present study evaluates the effectiveness...

journal_title：British journal of anaesthesia

authors： Cuper NJ,de Graaff JC,Hartman BJ,Verdaasdonk RM,Kalkman CJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Pain management in craniotomy patients is challenging, with mild-to-moderate pain intensity, moderate-to-high risk of postoperative nausea and vomiting (PONV), and potentially catastrophic consequences of analgesic-related side-effects. The aim of this study was to determine whether i.v. parecoxib administer...

journal_title：British journal of anaesthesia

authors： Williams DL,Pemberton E,Leslie K

更新日期：2011-09-01 00:00:00

abstract：:We have determined the influence of 0.1 minimum alveolar concentration (MAC) of sevoflurane on ventilation, the acute ventilatory response to a step change in end-tidal carbon dioxide and the ventilatory response to sustained hypercapnia in 10 healthy adult volunteers. Subjects undertook a preliminary 10-min period of...

journal_title：British journal of anaesthesia

authors： Pandit JJ,Manning-Fox J,Dorrington KL,Robbins PA

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The minimum effective volume of local anaesthetic needed to provide effective analgesia of the four main branches of the axillary brachial plexus is unknown. This study was performed to determine the minimum volume of local anaesthetic required to surround the nerves of the axillary brachial plexus and docum...

journal_title：British journal of anaesthesia

authors： Harper GK,Stafford MA,Hill DA

更新日期：2010-05-01 00:00:00

abstract：:Forty patients (age range 60-79 yr) undergoing transurethral surgery were allocated randomly to receive 0.5% plain bupivacaine 4 ml at the L2-3 (n = 20) or L4-5 (n = 20) space. The solution was injected over 30 s with the patient in the sitting position. The patient was kept sitting for 2 min, then placed supine and, ...

journal_title：British journal of anaesthesia

authors： Olsen KH,Nielsen TH,Kristoffersen E,Husegaard HC,Wernberg M,Dørup J

更新日期：1990-02-01 00:00:00

abstract：:This was a prospective, non-randomized, multicentre study of rocuronium (Org 9426) in 40 elective Caesarean section patients at full term without fetal distress. Anaesthesia was induced with thiopentone 4-6 mg kg-1 i.v. and rocuronium 0.6 mg kg-1 and maintained with isoflurane and nitrous oxide in oxygen. Monitors inc...

journal_title：British journal of anaesthesia

authors： Abouleish E,Abboud T,Lechevalier T,Zhu J,Chalian A,Alford K

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The efficacy of opioids typically decreases after long-term use owing to the development of tolerance. Glial activation and the upregulation of proinflammatory cytokines are related to the induction of tolerance. We investigated the effect of leukemia inhibitory factor (LIF) on morphine analgesia and toleran...

journal_title：British journal of anaesthesia

authors： Tu HJ,Kang KH,Ho SY,Liou HC,Liou HH,Lin CP,Fu WM

更新日期：2016-10-01 00:00:00

abstract：:Postoperative management following major surgery in patients with neuromuscular disorders associated with scoliosis is frequently complicated by sputum retention and ventilatory failure. This report demonstrates the successful perioperative management of an 11-yr-old boy with type II spinal muscular atrophy undergoing...

journal_title：British journal of anaesthesia

authors： Marchant WA,Fox R

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Propofol is used during living-related donor liver transplantation because its metabolism is not greatly affected by liver failure. However, the pharmacokinetics of propofol during liver transplantation have not been fully defined. The purpose of this study was to evaluate the apparent systemic clearance of ...

journal_title：British journal of anaesthesia

authors： Takizawa D,Sato E,Hiraoka H,Tomioka A,Yamamoto K,Horiuchi R,Goto F

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Pressure recording analytical method (PRAM) is a novel, arterial pulse contour-based method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have not assessed both absolute accuracy and ability to track changes in CO across a broad case mix. We aimed to compare CO as mea...

journal_title：British journal of anaesthesia

authors： Saxena R,Durward A,Puppala NK,Murdoch IA,Tibby SM

更新日期：2013-03-01 00:00:00