Effects of cardiopulmonary bypass on neurocognitive performance and cytokine release in old and diabetic rats.

abstract：:Nociceptin/orphanin FQ, N/OFQ, and its receptor NOP represent a non-opioid branch of the opioid superfamily that were first studied for their effects on pain responses. Both N/OFQ and NOP are involved in a wide range of 'non-pain' responses including immunomodulation and cardiovascular control. There is now growing in...

journal_title：British journal of anaesthesia

authors： Serrano-Gomez A,Thompson JP,Lambert DG

更新日期：2011-01-01 00:00:00

abstract：:Seventy-two adult surgical patients were studied to compare neuromuscular and cardiovascular effects of mivacurium chloride during nitrous oxide-fentanyl-thiopentone (BAL group) or nitrous oxide-halothane (HAL group) anaesthesia. Eighteen patients in the BAL group received an initial bolus of mivacurium, either the ED...

journal_title：British journal of anaesthesia

authors： From RP,Pearson KS,Choi WW,Abou-Donia M,Sokoll MD

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Acute pulmonary embolism (APE) is an important clinical problem in patients after major surgery and often remains a difficult diagnosis because of unspecific clinical symptoms. Therefore, we investigated the role of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) for the detection of APE. MET...

journal_title：British journal of anaesthesia

authors： Winkler BE,Schuetz W,Froeba G,Muth CM

更新日期：2012-12-01 00:00:00

abstract：:The relative analgesic efficacy and side-effect profile of peripheral nerve blockade (PNB) techniques compared with lumbar epidural analgesia for major knee surgery is unclear. We undertook a systematic review and meta-analysis of all randomized trials comparing epidural analgesia with PNB for major knee surgery. Eigh...

journal_title：British journal of anaesthesia

authors： Fowler SJ,Symons J,Sabato S,Myles PS

更新日期：2008-02-01 00:00:00

abstract：:We have compared the postoperative morphine requirements and analgesic efficacy of four doses of i.m. ketorolac 30 mg administered 6-hourly with placebo in a double-blind study of patients undergoing major or minor orthopaedic surgery. During the 24-h postoperative study period which began at the end of surgery, patie...

journal_title：British journal of anaesthesia

authors： Kinsella J,Moffat AC,Patrick JA,Prentice JW,McArdle CS,Kenny GN

更新日期：1992-07-01 00:00:00

abstract：:We tested the hypothesis that premedication with i.m. midazolam decreases core temperature dose-dependently. We studied six male volunteers, in random order, on 3 days: (1) no midazolam administration (control day), (2) midazolam 0.025 mg kg-1 i.m., (3) midazolam 0.075 mg kg-1 i.m. On the first day, subjects were main...

journal_title：British journal of anaesthesia

authors： Matsukawa T,Hanagata K,Ozaki M,Iwashita H,Koshimizu M,Kumazawa T

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:While volatile agents have been implicated in metastasis-enhancing effects on cancer cells, the effects of xenon are unknown. We investigated xenon- and sevoflurane-mediated effects on migration and expression of angiogenesis biomarkers in human breast adenocarcinoma cells. METHODS:MDA-MB-231 and MCF-7 cell...

journal_title：British journal of anaesthesia

authors： Ash SA,Valchev GI,Looney M,Ni Mhathuna A,Crowley PD,Gallagher HC,Buggy DJ

更新日期：2014-07-01 00:00:00

abstract：:In this report we present the case of a 77-yr-old man who underwent resection of the upper lobe of the left lung for a carcinoma, six weeks after percutaneous transluminal coronary angioplasty (PTCA) with stenting of the left anterior descending (LAD) and circumflex coronary arteries. Antiplatelet therapy with clopido...

journal_title：British journal of anaesthesia

authors： Marcucci C,Chassot PG,Gardaz JP,Magnusson L,Ris HB,Delabays A,Spahn DR

更新日期：2004-05-01 00:00:00

abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...

journal_title：British journal of anaesthesia

authors： Clarke TN,Foëx P,Roberts JG,Saner CA,Bennett MJ

更新日期：1980-03-01 00:00:00

abstract：:The trachea of a man who had cut his own throat was successfully intubated using a fibreoptic laryngoscope after attempts at conventional oral intubation had failed. The advantages of the fibreoptic instrument and the method of use in such an injury are discussed. ...

journal_title：British journal of anaesthesia

authors： Davies JR

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Ketamine is widely used as an i.v. anaesthetic agent and as a drug of abuse. Hepatocytes contribute to the metabolism of endogenous and exogenous substances. This study evaluated the toxic effects of S-(+)-ketamine and possible mechanisms using human hepatoma HepG2 cells as the experimental model. METHODS:H...

journal_title：British journal of anaesthesia

authors： Lee ST,Wu TT,Yu PY,Chen RM

更新日期：2009-01-01 00:00:00

abstract：:Continuous intercostal nerve blockade was used to provide analgesia after cholecystectomy. The blockade was maintained by the insertion of a single extradural catheter into an appropriate intercostal space and by "topping-up" with local anaesthetic on demand. Of the patients studied, 92%, and 76%, required no addition...

journal_title：British journal of anaesthesia

authors： Murphy DF

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Some patients have features that indicate possible difficulty with direct laryngoscopy for tracheal intubation. Prediction of the likely outcome and selection of patients for an enhanced management algorithm would reduce the possible harm from failed intubation attempts. METHODS:Adult elective patients were...

journal_title：British journal of anaesthesia

authors： Cook F,Lobo D,Martin M,Imbert N,Grati H,Daami N,Cherait C,Saïdi NE,Abbay K,Jaubert J,Younsi K,Bensaid S,Ait-Mamar B,Slavov V,Mounier R,Goater P,Bloc S,Catineau J,Abdelhafidh K,Haouache H,Dhonneur G

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The analgesia/nociception index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the analgesia/nociception balance during general anaesthesia. The aim of this study was to evaluate the ANI in the assessment of immediate postoperative pain in adult patients undergoing general...

journal_title：British journal of anaesthesia

authors： Boselli E,Daniela-Ionescu M,Bégou G,Bouvet L,Dabouz R,Magnin C,Allaouchiche B

更新日期：2013-09-01 00:00:00

abstract：:We describe an obstetric patient who developed incapacitating headache after inadvertent dural tap and was treated with repeated blood patching. She subsequently developed severe lumbar back pain which, after exclusion of suspected extradural abscess, was treated successfully with simple analgesics and physiotherapy. ...

journal_title：British journal of anaesthesia

authors： Palmer JH,Wilson DW,Brown CM

更新日期：1997-03-01 00:00:00

abstract：:We have studied the efficacy of i.v. clonidine to suppress post-extradural shivering in parturients. Forty healthy parturients who received extradural block for labour (n = 20) or for Caesarean section (n = 20) and who required treatment for shivering after delivery were allocated randomly to two groups. Group I recei...

journal_title：British journal of anaesthesia

authors： Capogna G,Celleno D

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Plethysmographic variability index (PVI) is an accurate predictor of fluid responsiveness in mechanically ventilated patients. However, the site of measurement of the plethysmographic waveform impacts its morphology and its respiratory variation. The goal of this study was to investigate the ability of PVI t...

journal_title：British journal of anaesthesia

authors： Desgranges FP,Desebbe O,Ghazouani A,Gilbert K,Keller G,Chiari P,Robin J,Bastien O,Lehot JJ,Cannesson M

更新日期：2011-09-01 00:00:00

abstract：:The effect of the administration of propranolol 0.15 mg per kg body weight i.v. on the metabolic response to pelvic surgery was compared with results in similar patients who had not received propranolol. The only significant difference between the two groups was a lower plasma insulin concentration in the beta-blockad...

journal_title：British journal of anaesthesia

authors： Cooper GM,Paterson JL,Mashiter K,Hall GM

更新日期：1980-12-01 00:00:00

abstract：:The pharmacokinetics of propofol in a dose of 2.5 mg kg-1 given via a vein in the antecubital fossa were studied in 18 patients. Anaesthesia was maintained with nitrous oxide in oxygen in all patients. The effects of pretreatment with fentanyl (n = 6) and maintenance with halothane (n = 6) on the pharmacokinetics of p...

journal_title：British journal of anaesthesia

authors： Cockshott ID,Briggs LP,Douglas EJ,White M

更新日期：1987-09-01 00:00:00

abstract：:We have studied the immediate and long term (up to 28 days) effects of short and long bevelled needle impalement of the rat sciatic nerve. Three techniques were used to assess neural trauma and its consequences: stained longitudinal nerve sections were assessed by light microscopy and scored for injury; the extravasat...

journal_title：British journal of anaesthesia

authors： Rice AS,McMahon SB

更新日期：1992-11-01 00:00:00

abstract：:Volatile anaesthetics have been shown to have direct relaxant effects on airway smooth muscle. We have examined the effects of 0.9, 1.9, and 2.8 dog MAC of desflurane and halothane on isolated proximal and distal canine airways precontracted with acetylcholine. The proximal and distal airway smooth muscle relaxed with...

journal_title：British journal of anaesthesia

authors： Mazzeo AJ,Cheng EY,Bosnjak ZJ,Coon RL,Kampine JP

更新日期：1996-06-01 00:00:00

abstract：:Neurone specific enolase (NSE) and S-100 beta protein have been used as markers of brain damage. We hypothesized that blood concentrations of NSE and S-100 beta protein reflect cognitive dysfunction after abdominal surgery. We studied 65 elderly patients in whom neuropsychological testing was performed before abdomina...

journal_title：British journal of anaesthesia

authors： Rasmussen LS,Christiansen M,Rasmussen H,Kristensen PA,Moller JT

更新日期：2000-02-01 00:00:00

abstract：:Protein kinase C (PKC) is a key regulatory enzyme that has been implicated as a molecular target for the action of general anaesthetics. We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol...

journal_title：British journal of anaesthesia

authors： Hemmings HC Jr,Adamo AI

更新日期：1997-02-01 00:00:00

abstract：:The insufflation of oxygen at 1 litre kg-1 min-1 via two endobronchial catheters (called continuous flow ventilation (CFV)) maintained a normal PaCO2 and a constant PaO2 in anaesthetized paralysed dogs and in five out of seven cats. In two cats with a high carbon dioxide production, CFV failed to maintain carbon dioxi...

journal_title：British journal of anaesthesia

authors： Perl A,Whitwam JG,Chakrabarti MK,Taylor VM

更新日期：1986-05-01 00:00:00

abstract：:The rate of gastric emptying in pregnancy was measured indirectly using the rate of paracetamol absorption in four groups of 15 patients: non-pregnant controls, first trimester patients presenting for termination of pregnancy, second trimester patients presenting for prostaglandin termination of pregnancy, and patient...

journal_title：British journal of anaesthesia

authors： Macfie AG,Magides AD,Richmond MN,Reilly CS

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Myocardial injury after noncardiac surgery is common, although the exact pathophysiology is unknown. It is plausible that hypotension after surgery is relevant for the development of myocardial injury. The authors evaluated whether low mean arterial pressures (MAPs) after surgery are related to an increased ...

journal_title：British journal of anaesthesia

authors： van Lier F,Wesdorp FHIM,Liem VGB,Potters JW,Grüne F,Boersma H,Stolker RJ,Hoeks SE

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The diagnosis of abdominal compartment syndrome depends upon the demonstration of an elevated intra-abdominal pressure (IAP). Direct measures of IAP are impractical in the critical care unit; intravesical pressure (IVP) and intragastric pressure (IGP) should represent acceptable surrogate measures. IVP is th...

journal_title：British journal of anaesthesia

authors： Turnbull D,Webber S,Hamnegard CH,Mills GH

更新日期：2007-05-01 00:00:00

abstract：:We describe the management of three patients undergoing awake carotid surgery who developed signs of cerebral ischaemia after carotid cross-clamping. Drug treatment to increase arterial blood pressure above baseline reversed the neurological deficit and an internal carotid artery shunt was not needed. Shunt insertion ...

journal_title：British journal of anaesthesia

authors： Stoneham MD,Warner O

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-co...

journal_title：British journal of anaesthesia

authors： Lee JR,Jung CW,Lee YH

更新日期：2007-12-01 00:00:00

abstract：:We report the anaesthetic management of a male neonate with congenital cyst adenoid malformation (CCAM) of the lung who underwent thoracotomy for resection of CCAM 24 h after birth and again at 24 days. The initial operation involved a 10-day admission to a paediatric intensive care unit (PICU) requiring ventilation, ...

journal_title：British journal of anaesthesia

authors： Guruswamy V,Roberts S,Arnold P,Potter F

更新日期：2005-08-01 00:00:00