Spinal analgesia with plain 0.5% bupivacaine administered at spinal interspace L2-3 or L4-5.

abstract：:In clinical use, the concentrations of local anaesthetics at the site of action are unknown. With the method described here, concentrations of local anaesthetics can be predetermined and kept constant at the site of action. In six volunteers, a blister was raised on the ventral surface of the forearm. After removal of...

journal_title：British journal of anaesthesia

authors： Wiesemes R,Klement W,Novotny GE,Lipfert P

更新日期：1993-05-01 00:00:00

abstract：:This review looks at the challenges faced when monitoring patients in the field environment. It is considered from the perspective of the UK Defence Medical Services and their experiences over the past 20 yr. The lessons learned are applicable to many other circumstances where a high standard of care, for a large spec...

journal_title：British journal of anaesthesia

authors： McGuire NM

更新日期：2006-07-01 00:00:00

abstract：:Using cats with chronically implanted brain electrodes, we have compared the effects of propofol on CNS electrical activities with those of thiopentone. Ten cats were allocated to receive either propofol (n = 5) or thiopentone (n = 5). Cats were anaesthetized initially with 4% halothane in oxygen. The trachea was intu...

journal_title：British journal of anaesthesia

authors： Tomoda K,Shingu K,Osawa M,Murakawa M,Mori K

更新日期：1993-09-01 00:00:00

abstract：:We have studied 13 patients with diabetic nephropathy and 13 patients with uraemia of other origin undergoing renal transplantation, and 12 control patients undergoing general surgery. QTc dispersion and maximum QTc interval were calculated from the 12-lead ECG, and cardiovascular autonomic function tests were perform...

journal_title：British journal of anaesthesia

authors： Kirvelä M,Yli-Hankala A,Lindgren L

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:There has been increasing use of invasive techniques, such as extracorporeal organ support, in intensive care units (ICU), and declining autopsy rates. Thus, new measures are needed to maintain high-quality standards. We investigated the potential of computed tomography (CT)-based virtual autopsy to substitu...

journal_title：British journal of anaesthesia

authors： Wichmann D,Heinemann A,Zähler S,Vogel H,Höpker W,Püschel K,Kluge S

更新日期：2018-06-01 00:00:00

abstract：:We have examined changes in plasma concentrations of calcium in seven anaesthetized pigs during i.v. infusion of irrigating fluid containing 1.5% glycine. Volumes infused were 875 ml at 20 min (22 ml kg-1), 1475 ml at 40 min and 2075 ml at 60 min (75 ml kg-1). Plasma concentrations of sodium decreased from 134.5 (SD 3...

journal_title：British journal of anaesthesia

authors： Chassard D,Berrada K,Tournadre JP,Boulétreau P

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Ketamine-induced neuroapoptosis has been attributed to diverse stress-related mechanisms. Glycogen synthase kinase-3β (GSK-3β) is a multifunctional kinase that is active in neuronal development and linked to neurodegenerative disorders. We hypothesized that ketamine would enhance GSK-3β-induced neuroapopotos...

journal_title：British journal of anaesthesia

authors： Liu JR,Baek C,Han XH,Shoureshi P,Soriano SG

更新日期：2013-06-01 00:00:00

abstract：:Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal administration aft...

journal_title：British journal of anaesthesia

authors： Chauvin M,Samii K,Schermann JM,Sandouk P,Bourdon R,Viars P

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:The analgesia/nociception index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the analgesia/nociception balance during general anaesthesia. The aim of this study was to evaluate the ANI in the assessment of immediate postoperative pain in adult patients undergoing general...

journal_title：British journal of anaesthesia

authors： Boselli E,Daniela-Ionescu M,Bégou G,Bouvet L,Dabouz R,Magnin C,Allaouchiche B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Patient dissatisfaction has been previously associated with motor block in shoulder surgery patients receiving brachial plexus block. For elective minor wrist and hand surgery, we tested whether a regional block accelerating the early return of upper extremity motor function would improve patient satisfactio...

journal_title：British journal of anaesthesia

authors： Fredrickson MJ,Wolstencroft PJ,Chinchanwala S,Boland MR

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for...

journal_title：British journal of anaesthesia

authors： Zuppa AF,Nicolson SC,Wilder NS,Ibla JC,Gottlieb EA,Burns KM,Stylianou M,Trachtenberg F,Ni H,Skeen TH,Andropoulos DB,Pediatric Heart Network Investigators.

更新日期：2019-12-01 00:00:00

abstract：:Recommendations for resuscitation of patients in early haemorrhagic shock, with active ongoing bleeding, have evolved in recent years. This review covers current theories of the pathophysiology of shock and recommended treatments, including damage control surgery, deliberate hypotensive management, administration of a...

journal_title：British journal of anaesthesia

authors： Dutton RP

更新日期：2012-12-01 00:00:00

abstract：:Acetazolamide, a carbonic anhydrase inhibitor, may cause significant disturbances in carbon dioxide transport and elimination. In this study, end-tidal carbon dioxide monitoring has been used to study the correlation between arterial carbon dioxide (PaCO2) and end-tidal carbon dioxide partial pressure (PE'CO2) in rabb...

journal_title：British journal of anaesthesia

authors： Lee TS

更新日期：1994-08-01 00:00:00

abstract：:We report the anaesthetic management of a male neonate with congenital cyst adenoid malformation (CCAM) of the lung who underwent thoracotomy for resection of CCAM 24 h after birth and again at 24 days. The initial operation involved a 10-day admission to a paediatric intensive care unit (PICU) requiring ventilation, ...

journal_title：British journal of anaesthesia

authors： Guruswamy V,Roberts S,Arnold P,Potter F

更新日期：2005-08-01 00:00:00

abstract：:Three hundred and twenty adults (ASA grade I, both sexes), received diazepam 10 mg by mouth (50% received atropine 7 micrograms kg-1 in addition) i.m. 45 min before operation. Patients were then allocated randomly to undergo general anaesthesia with either a nitrous oxide-neurolept technique or nitrous oxide-halothane...

journal_title：British journal of anaesthesia

authors： Wierda JM,Maestrone E,Bencini AF,Boyer A,Rashkovsky OM,Lip H,Karliczek R,Ket JM,Agoston S

更新日期：1989-02-01 00:00:00

abstract：:Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenaline 10 mumol litre-1 was used as a control. In contrast with noradrenaline...

journal_title：British journal of anaesthesia

authors： Desborough JP,Jones PM,Persaud SJ,Howell SL

更新日期：1993-02-01 00:00:00

abstract：:As constant hypoxaemia itself may trigger development of apnoea and periodic breathing, we have studied the effect of oxygen therapy on the occurrence of late postoperative episodic hypoxaemia. Thirty-five patients without cardiopulmonary disease and undergoing elective total hip replacement were monitored with a puls...

journal_title：British journal of anaesthesia

authors： Rosenberg J,Pedersen MH,Gebuhr P,Kehlet H

更新日期：1992-01-01 00:00:00

abstract：:The experimental effort that has been expended in investigating the effects of general anaesthetics on LGICs has been enormous over the past decade. Members of all three LGIC superfamilies have been examined using electrophysiological techniques. Anaesthetics that have been examined include volatile anaesthetics, gase...

journal_title：British journal of anaesthesia

authors： Dilger JP

更新日期：2002-07-01 00:00:00

abstract：:To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...

journal_title：British journal of anaesthesia

authors： Ray DC,Bomont R,Mizushima A,Kugimiya T,Forbes Howie A,Beckett GJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Intravenous amino acid infusion during general anaesthesia prevents decreases in core temperature resulting from increased energy expenditure and heat accumulation. METHODS:We investigated whether such stimulation also occurs during spinal anaesthesia, which blocks sympathetic nervous activity. We examined ...

journal_title：British journal of anaesthesia

authors： Kasai T,Nakajima Y,Matsukawa T,Ueno H,Sunaguchi M,Mizobe T

更新日期：2003-01-01 00:00:00

abstract：:Methodology for assessment of depth of anaesthesia based on analysis of the electroencephalogram (EEG) is controversial. Techniques range from display of single measures, for example median value of the frequency spectrum, to dedicated pattern recognition systems based on measures of several EEG features. We have comp...

journal_title：British journal of anaesthesia

authors： Thomsen CE,Prior PF

更新日期：1996-08-01 00:00:00

abstract：:In order to investigate the analgesic effect of timing of administration of ketorolac 10 mg i.v., we recorded patient-controlled use of diamorphine at 2, 4 and 12 h after abdominal hysterectomy. In a randomized, double-blind trial, 30 patients received ketorolac before skin incision and 28 after skin closure. A contro...

journal_title：British journal of anaesthesia

authors： Rogers JE,Fleming BG,Macintosh KC,Johnston B,Morgan-Hughes JO

更新日期：1995-07-01 00:00:00

abstract：:We have used the technique of double-blind sequential allocation to quantify the minimum local analgesic concentration (MLAC) of extradural bupivacaine for women in early (median cervical dilatation 2 cm) and late (median cervical dilatation 5 cm) labour. The first bolus was 20 ml of the bupivacaine test solution. The...

journal_title：British journal of anaesthesia

authors： Capogna G,Celleno D,Lyons G,Columb M,Fusco P

更新日期：1998-01-01 00:00:00

abstract：:We have examined the effect of isoflurane, halothane and fentanyl on heart rate variability (HRV) using power spectral analysis (PSA). Forty patients were allocated randomly to receive one of four anaesthetic techniques. Anaesthesia was induced with propofol 2 mg kg-1 and all patients breathed a mixture of 66% nitrous...

journal_title：British journal of anaesthesia

authors： Galletly DC,Westenberg AM,Robinson BJ,Corfiatis T

更新日期：1994-02-01 00:00:00

abstract：:We describe the performance of the pneuPAC hyperbaric variant HB, a ventilator designed for use in a one-man hyperbaric chamber. The ventilator delivered minute volumes of 11-23 litre at 1 atm abs to 7.6-16 litre at 2.5 atm abs. The delivered minute volume may be controlled easily from outside the chamber by manipulat...

journal_title：British journal of anaesthesia

authors： Spittal MJ,Hunter SJ,Jones L

更新日期：1991-10-01 00:00:00

abstract：:We have measured in a double-blind study the changes in intraocular pressure (IOP) in 40 consecutive patients (pretreated with fentanyl or alfentanil) who received suxamethonium and tracheal intubation. Although IOP increased significantly following administration of suxamethonium, mean IOP in both groups remained sig...

journal_title：British journal of anaesthesia

authors： Sweeney J,Underhill S,Dowd T,Mostafa SM

更新日期：1989-12-01 00:00:00

abstract：:We have compared, in a randomized, double-blind study, the pharmacokinetics of ropivacaine and bupivacaine during labour. Total and free plasma concentrations of ropivacaine and bupivacaine were measured after the first of two extradural doses. The main dose was 20 mg (test dose) and 30 mg, with a top-up dose of 25 mg...

journal_title：British journal of anaesthesia

authors： McCrae AF,Westerling P,McClure JH

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or appare...

journal_title：British journal of anaesthesia

authors： Dahan A,Yassen A,Romberg R,Sarton E,Teppema L,Olofsen E,Danhof M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Cardiac surgery with cardiopulmonary bypass (CPB) is commonly perceived as a risk factor for decline in renal function, especially in patients with preoperative renal dysfunction. There are few data on the effects of CPB on renal function in patients with mild preoperative renal dysfunction. The purpose of t...

journal_title：British journal of anaesthesia

authors： Loef BG,Henning RH,Navis G,Rankin AJ,van Oeveren W,Ebels T,Epema AH

更新日期：2008-06-01 00:00:00

abstract：:Following a paravertebral surgical incision, mature, female rats under ether anaesthesia were exposed to either 3% nitrous oxide, continuously for 48 h, or 50% nitrous oxide, 4 h each day for 7 days. For each exposure group, a similar number of rats was exposed to atmospheres containing no nitrous oxide. Wound healing...

journal_title：British journal of anaesthesia

authors： Algie TA,Seth A,Barbenel JC,Galloway DJ,Gray WM,Spence AA

更新日期：1985-06-01 00:00:00