Plasma concentration of morphine after i.m., extradural and intrathecal administration.

Abstract:

:Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal administration after i.m. and extradural administration (P less than 0.05) at 2, 10, 15 and 30 min. We conclude that morphine given extradurally has a greater initial rate of vascular absorption than morphine given intrathecally and is similar to that observed after i.m. administration.

journal_name

Br J Anaesth

authors

Chauvin M,Samii K,Schermann JM,Sandouk P,Bourdon R,Viars P

doi

10.1093/bja/53.9.911

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

911-3

issue

9

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46866-8

journal_volume

53

pub_type

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