Abstract：
BACKGROUND:Magnesium is a calcium and an NMDA-receptor antagonist and can modify important mechanisms of nociception. We evaluated the co-analgesic effect of magnesium in the postoperative setting after on-pump cardiac surgery. METHODS:Forty patients randomly received either magnesium gluconate as an i.v. bolus of 0.21 mmol kg(-1) (86.5 mg kg(-1)) followed by a continuous infusion of 0.03 mmol(-1) kg(-1) h(-1) (13.8 mg kg(-1) h(-1)) or placebo for 12 h after tracheal extubation. After surgery, remifentanil was decreased to 0.05 microg kg(-1) min(-1) and titrated according to a pain intensity score (PIS, range 1-6) in the intubated, awake patient and a VAS scale (range 1-100) after extubation. If PIS was > or =3 or VAS > or =30, the infusion was increased by 0.01 microg kg(-1) min(-1); if ventilatory frequency was < or =10 min(-1) it was decreased by the same magnitude. RESULTS:Magnesium lowered the cumulative remifentanil requirement after surgery (P<0.05). PIS > or =3 was more frequent in the placebo group (P<0.05). Despite increased remifentanil demand, VAS scores were also higher in the placebo group at 8 (2 vs 8) and 9 h after extubation (2 vs 7) (P<0.05). Dose reductions attributable to a ventilatory frequency < or =10 min(-1) occurred more often in the magnesium group (17 vs 6; P<0.05). However, time to tracheal extubation was not prolonged. CONCLUSIONS:Magnesium gluconate moderately reduced the remifentanil consumption without serious side-effects. The opioid-sparing effect of magnesium may be greater at higher pain intensities and with increased dosages.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Steinlechner B,Dworschak M,Birkenberg B,Grubhofer G,Weigl M,Schiferer A,Lang T,Rajek Adoi
10.1093/bja/ael037subject
Has Abstractpub_date
2006-04-01 00:00:00pages
444-9issue
4eissn
0007-0912issn
1471-6771pii
S0007-0912(17)35149-8journal_volume
96pub_type
杂志文章,随机对照试验abstract：:Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.11.1091
更新日期：1976-11-01 00:00:00
abstract：BACKGROUND:Age and diabetes mellitus have been identified as independent risk factors for cognitive decline after cardiac surgery with cardiopulmonary bypass (CPB). We tested the effects of CPB on cognitive function in aged and diabetic rats utilizing the Morris water maze (MWM). METHODS:Aged rats (26 months) were ran...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aem116
更新日期：2007-08-01 00:00:00
abstract：:We determined in 51 healthy patients undergoing body surface surgery the dose requirements for propofol, as part of a total i.v. anaesthesia technique with an alfentanil infusion. After premedication with temazepam, patients received alfentanil 50 micrograms kg-1 followed by an infusion of 50 micrograms kg-1 h-1. Pati...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/65.2.157
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:We previously demonstrated that i.v. emulsified isoflurane induces general anaesthesia in animals. In this study, we compared the pharmacokinetics of emulsified isoflurane given as i.v. bolus and as infusion in beagle dogs. METHODS:Sixteen beagle dogs were assigned randomly to a bolus group comprising three...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aes311
更新日期：2013-01-01 00:00:00
abstract：:A new method has been developed to measure end-tidal carbon dioxide partial pressure (PECO2) during high frequency jet ventilation (HFJV). A digital flow controller incorporated in a computerized high frequency jet ventilator was used to deliver either a single deep breath or a series of three deep breaths. On user re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.7.47
更新日期：1989-01-01 00:00:00
abstract：:We studied 40 elderly patients undergoing cataract surgery. Ten non-insulin-dependent diabetes mellitus (NIDDM) patients received standardized general anaesthesia, 10 NIDDM patients received local anaesthesia using retrobulbar block, 10 non-diabetic control patients received general anaesthesia and 10 non-diabetic con...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/74.5.500
更新日期：1995-05-01 00:00:00
abstract：:We have investigated, in six healthy male volunteers, the effect of high thoracic extradural anaesthesia on the ventilatory pattern and hypercapnic ventilatory response. Ventilatory variables were determined using a respiratory inductive plethysmograph. Duration of inspiration, rib cage excursion and its contribution ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.4.362
更新日期：1989-04-01 00:00:00
abstract：:Seventy-six Chinese patients aged between 15 and 30 yr, undergoing 3rd molar extraction, were randomly allocated to two groups. One group received halothane and the other isoflurane. The incidence of arrhythmia during surgery under anaesthesia with isoflurane was significantly less than with halothane. Sinus tachycard...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.4.394
更新日期：1986-04-01 00:00:00
abstract：BACKGROUND:Multiple cognitive and psychiatric disorders are associated with an increased tonic inhibitory conductance that is generated by α5 subunit-containing γ-aminobutyric acid type A (α5 GABAA) receptors. Negative allosteric modulators that inhibit α5 GABAA receptors (α5-NAMs) are being developed as treatments for...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.11.032
更新日期：2020-12-30 00:00:00
abstract：BACKGROUND:Studies of the accuracy of partial rebreathing measurements of pulmonary blood flow (PBF) in patients with abnormal lungs have not fully explained the sources of error. METHODS:We used computer models of emphysema and pulmonary embolism incorporating both ventilation-perfusion (V/Q) and ventilation-volume (...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael214
更新日期：2006-11-01 00:00:00
abstract：:This article briefly reviews psychological aspects of pain, paying special attention to chronic pain. The review considers the interruptive and interference effects of pain and its impact on a person's identity. The importance of processes related to interruption, interference, and identity will vary across people and...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aen123
更新日期：2008-07-01 00:00:00
abstract：:Integrated electromyographic studies in burned patients, and in normal controls, during the administration of small doses of suxamethonium (0.1 or 0.2 mg kg-1) have shown that the level of paralysis and the duration of paralysis are significantly increased in burn patients and that the effect is greater with larger bu...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.8.1017
更新日期：1987-08-01 00:00:00
abstract：:Experiments were performed on rats using two analgesimetric tests (tail-flick; hot-plate) before and after injection i.v. of graded doses of aprotinin (12.5, 25.0 and 50 KIU g-1). A dose-related analgesic effect was noted with both tests. Prior administration of naloxone 0.001 mg g-1 i.p. inhibited the analgesic actio...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.11.1107
更新日期：1980-11-01 00:00:00
abstract：:We describe three histaminoid reactions occurring on induction of anaesthesia. The patients were all resuscitated successfully and subsequent skin testing suggested sensitivity to rocuronium. In this hospital, the incidence of such reactions is of the order of 1 in 3000. This may be coincidental but suggests that ther...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/oxfordjournals.bja.a013365
更新日期：2000-01-01 00:00:00
abstract：:We report the extradural administration of low-dose morphine in 10 ml of 10% dextrose (2-3 mg) to 98 adult patients with various types of acute and chronic pain. Extradural morphine injections were given either via a Tuohy needle (single or repeat injection) or via an extradural catheter. Pain relief was evaluated by ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.3.247
更新日期：1980-03-01 00:00:00
abstract：:We studied the elimination rate of nitrous oxide in 36 patients undergoing orthopaedic surgery. They were allocated randomly to one of six groups which differed in time of nitrous oxide exposure and mode of ventilation. In order to simulate recovery conditions, nitrous oxide administration was discontinued after 30, 6...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/71.2.189
更新日期：1993-08-01 00:00:00
abstract：:Bupivacaine 2.5 mg kg-1 (0.5 ml kg-1 of 0.5% solution), with or without adrenaline 5 micrograms ml-1, was administered by interpleural injection to 12 patients after elective cholecystectomy. Noncompartmental analysis indicated that the addition of adrenaline had no effect on total body clearance, apparent volume of d...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/64.6.662
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,meta分析,评审
doi：10.1093/bja/aeu137
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The objective of this study was to determine whether assessment of stroke volume (SV) and measurement of exhaled end-tidal carbon dioxide [Formula: see text] during an end-expiratory occlusion (EEO) test can predict fluid responsiveness in the operating theatre. METHODS:Forty-two subjects monitored by oesop...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet582
更新日期：2014-06-01 00:00:00
abstract：:We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.6.935
更新日期：2001-12-01 00:00:00
abstract：:To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.3.404
更新日期：1996-09-01 00:00:00
abstract：:A blind comparison was made of butorphanol 2 mg with morphine 10 mg i.m. as the sole premedication in four groups, each of 10 women, undergoing total abdominal hysterectomy. On both subjective and objective grounds, butorphanol was as effective as morphine with the advantage of fewer unwanted side-effects, although on...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/56.4.363
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:Dexmedetomidine is an α-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques. We therefore designed this prospective, double-blinded, controlled volunteer study to investigate the effects of dexmedetomidine as an adjuvant to ropivacaine on pe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aes400
更新日期：2013-03-01 00:00:00
abstract：:The physical and pharmacological properties of the structural isomers isoflurane and enflurane differ from each other and from those of other potent inhaled anaesthetics. The minimum alveolar concentration (MAC) for isoflurane (1.15%) is one-and-one-half times that for halothane (0.75%) and two-thirds that for enflura...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:Tracheal tube tip and cuff positions of different cuffed paediatric tracheal tube brands in the trachea can vary with design. METHODS:Data from three clinical studies with measured tracheal lengths were pooled in a database including 422 children aged from birth to 16 yr. Dimensional data of seven cuffed pa...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2018.05.002
更新日期：2018-08-01 00:00:00
abstract：:A recently installed anti-pollution system, initially designed to function in a passive mode, was evaluated, but found to be inconstant in its performance. A simple method of making the system active is described and evaluated. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.5.439
更新日期：1977-05-01 00:00:00
abstract：BACKGROUND:The efficacy of opioids typically decreases after long-term use owing to the development of tolerance. Glial activation and the upregulation of proinflammatory cytokines are related to the induction of tolerance. We investigated the effect of leukemia inhibitory factor (LIF) on morphine analgesia and toleran...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aew247
更新日期：2016-10-01 00:00:00
abstract：:Data from two published and one new meta-analysis were reviewed to compare the antiemetic efficacy of three different anaesthetic regimens: (i) propofol anaesthesia compared with another anaesthetic (control); (ii) anaesthesia without nitrous oxide compared with the same anaesthetic with nitrous oxide (control); (iii)...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,meta分析
doi：10.1093/bja/78.3.256
更新日期：1997-03-01 00:00:00
abstract：:The Walton-Brodie strain gauge arch is an instrument that quantitatively measures CF. Like many methods, the strain gauge arch is affected by loading conditions and heart rate. Nevertheless, this methodology, when properly used, has proved very useful in describing the direct action of anaesthetic drugs. Knowledge fro...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/60.suppl_1.78s
更新日期：1988-01-01 00:00:00
abstract：:Muscle biopsy and in vitro contracture tests for diagnosis of susceptibility to malignant hyperthermia (MH) were performed in two patients who had developed fever and severe myolysis during exercise. MH susceptibility was confirmed in one patient, but in the other, exercise-induced heat stroke proved to be the correct...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/66.1.138
更新日期：1991-01-01 00:00:00
