Analgesic effect of aprotinin in the rat and its inhibition by naloxone.

abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...

journal_title：British journal of anaesthesia

authors： Clarke TN,Foëx P,Roberts JG,Saner CA,Bennett MJ

更新日期：1980-03-01 00:00:00

abstract：:The neuromuscular and cardiovascular effects of atracurium were compared during nitrous oxide-isoflurane and nitrous oxide-fentanyl anaesthesia in healthy surgical patients. The dose-response curve was shifted significantly to the left during nitrous oxide-isoflurane anaesthesia (ED50 0.068 mg kg-1) as compared with n...

journal_title：British journal of anaesthesia

authors： Rupp SM,Fahey MR,Miller RD

更新日期：1983-01-01 00:00:00

abstract：:Following antagonism of tubocurarine block with a mixture of atropine 20 microgram/kg and neostigmine 50 microgram/kg in 20 children, heart rate decreased from a control value of 110.4 beat/min to 90.1 at 5 min and 89.2 at 6 min (P less than 0.02). Stroke volume index did not change during the first 5 min from a contr...

journal_title：British journal of anaesthesia

authors： Salem MR,Toyama T,Wong AY,Jacobs HK,Bennett EJ

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:We defined the nature of the pharmacological interaction after intrathecal co-administration of ginsenosides with clonidine, and clarified the contribution of the α-2 adrenoceptors on the effect of ginsenosides. METHODS:Pain was evoked by injection of a formalin solution (5%, 50 μl) into the hindpaw of male...

journal_title：British journal of anaesthesia

authors： Yoon MH,Huang LJ,Choi JI,Lee HG,Kim WM,Kim CM

更新日期：2011-03-01 00:00:00

abstract：:The relative sensitivity of sympathetic preganglionic and postganglionic axons, B and C fibres, respectively, to two structurally dissimilar local anaesthetics was examined. The concentration of amethocaine (ester-linked tertiary amine) or prilocaine (amide-linked secondary amine) required to reduce the B fibre compou...

journal_title：British journal of anaesthesia

authors： Scurlock JE,Heavner JE,de Jong RH

更新日期：1975-11-01 00:00:00

abstract：:We have examined the correlation between the evoked electromyographic response in the first dorsal interosseous muscle of the hand, temperature and forearm position in 40 female patients after enflurane anaesthesia with spontaneous breathing. In 20 patients the supinated forearm with the wrist extended was immobilized...

journal_title：British journal of anaesthesia

authors： Smith DC,Booth JV

更新日期：1994-04-01 00:00:00

abstract：:One hundred and eighty-five patients were allocated at random to receive pethidine with diazepam (in an emulsion), or pethidine with midazolam i.v. as sedation for upper gastrointestinal endoscopy. Sedation and conditions for examination were comparable and satisfactory in both groups. Midazolam produced more amnesia ...

journal_title：British journal of anaesthesia

authors： Magni VC,Frost RA,Leung JW,Cotton PB

更新日期：1983-11-01 00:00:00

abstract：:We studied psychomotor performance in 10 healthy volunteers during recovery after a target-controlled infusion of propofol. Choice reaction time, dual task tracking with secondary reaction time and a within-list recognition task were assessed at target blood propofol concentrations of 0.8, 0.4 and 0.2 microgram ml-1. ...

journal_title：British journal of anaesthesia

authors： Grant SA,Murdoch J,Millar K,Kenny GN

更新日期：2000-09-01 00:00:00

abstract：:Logistical and ethical reasons make conducting clinical research in paediatric practice difficult, and therefore safe and efficacious advances are dependent on good preclinical research. For example, notable advances have been made in preclinical studies of pain processing that correlate well with patient data. Other ...

journal_title：British journal of anaesthesia

authors： Sanders RD,Ma D,Brooks P,Maze M

更新日期：2008-11-01 00:00:00

abstract：:The analgesic effects of buprenorphine 2 microgram/kg--1 and 8 microgram. kg--1 were compared with those of pethidine 1 mg. kg--1 and pentazocine 0.6 mg.kg--1 in 172 patients recovering from surgery. The drugs were given by i.m. injection in the period immediately after operation and the quality of pain relief was ass...

journal_title：British journal of anaesthesia

authors： Hovell BC

更新日期：1977-09-01 00:00:00

abstract：:The effects of age on the dose of Org NC 45 were studied in 24 healthy, anaesthetized patients using an on-demand infusion of the drug which produced a stable twitch height of 10% of its initial value. The patients were allocated as follows: group I = age less than 40 yr; group II = 40-60 yr and group III = age greate...

journal_title：British journal of anaesthesia

authors： d'Hollander A,Massaux F,Nevelsteen M,Agoston S

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Intubation of a patient with limited cervical spine movement or in whom movement of the cervical spine is not desirable is always a challenge even to the most experienced anaesthesiologist. The intubating laryngeal mask airway (ILMA) and the Bullard laryngoscope (BL) are two instruments recommended for endot...

journal_title：British journal of anaesthesia

authors： Nileshwar A,Thudamaladinne A

更新日期：2007-08-01 00:00:00

abstract：:Protein kinase C (PKC) is a key regulatory enzyme that has been implicated as a molecular target for the action of general anaesthetics. We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol...

journal_title：British journal of anaesthesia

authors： Hemmings HC Jr,Adamo AI

更新日期：1997-02-01 00:00:00

abstract：:Thirteen of 31 Belgian Landrace pigs developed malignant hyperthermia (MH) after breathing halothane. A short period of exercise 1 h before the administration of the triggering agent increased the incidence of the syndrome to 100% in eight similar pigs. Clinical symptoms were more marked and developed more rapidly in ...

journal_title：British journal of anaesthesia

authors： van den Hende C,Lister D,Muylle E,Ooms L,Oyaert W

更新日期：1976-09-01 00:00:00

abstract：:In order to evaluate simple means of determining the rate of recovery after general anaesthesia, the usefulness of the critical flicker fusion threshold test, the Maddox wing apparatus and the visual analogue scale were compared. The postanaesthetic recovery score was used as a reference. Two patient groups (n = 15 in...

journal_title：British journal of anaesthesia

authors： Manner T,Kanto J,Salonen M

更新日期：1987-08-01 00:00:00

abstract：Background:Checklists can reduce medical errors. However, the effectiveness of checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual patient. Our purpose in this simulation-base...

journal_title：British journal of anaesthesia

authors： De Bie AJR,Nan S,Vermeulen LRE,Van Gorp PME,Bouwman RA,Bindels AJGH,Korsten HHM

更新日期：2017-08-01 00:00:00

abstract：:The value of the continuous monitoring of end-tidal carbon dioxide concentration as an indicator of the acute intraoperative interruption of pulmonary blood flow, in patients with pre-existing restrictions of pulmonary blood flow undergoing closed heart surgery, is illustrated by two case reports. Decreases in end-tid...

journal_title：British journal of anaesthesia

authors： Schuller JL,Bovill JG,Nijveld A

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to investigate the effects of increasing doses of norepinephrine (NE) with or without arginine-vasopressin (AVP) on intestinal oxygen supply and jejunal mucosal tissue oxygen tension in an acute endotoxic pig model. METHODS:In this prospective, randomized, experimental...

journal_title：British journal of anaesthesia

authors： Maier S,Hasibeder W,Pajk W,Hengl C,Ulmer H,Hausdorfer H,Wurzinger B,Knotzer H

更新日期：2009-11-01 00:00:00

abstract：:We conducted a randomized, double-blind comparison of 8% sevoflurane and propofol as induction agents for day-case cystoscopy in 102 patients. All patients received an i.v. cannula and breathed oxygen 5 litre min-1. Anaesthesia was induced with propofol i.v. or inhalation of 8% sevoflurane and 10% Intralipid (as a pla...

journal_title：British journal of anaesthesia

authors： Thwaites A,Edmends S,Smith I

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Priming during anaesthesia has been hard to replicate and the conditions under which it occurs remain poorly understood. We replicated and extended a recent study to determine whether intraoperative priming during propofol and nitrous oxide anaesthesia is a reliable phenomenon, whether it occurs due to aware...

journal_title：British journal of anaesthesia

authors： Deeprose C,Andrade J,Harrison D,Edwards N

更新日期：2005-01-01 00:00:00

abstract：:Sleep disordered breathing is a common problem affecting all age groups, particularly in association with certain other medical conditions and syndromes. The pathological consequences of the disorder may be severe, with significant implications for the perioperative management of sufferers. Research into the effects o...

journal_title：British journal of anaesthesia

authors： Loadsman JA,Hillman DR

更新日期：2001-02-01 00:00:00

abstract：:Dose-duration relationships for vecuronium were determined and the duration of action produced by vecuronium 0.3 mg kg-1 shown to equal that of pancuronium 0.1 mg kg-1. Using these doses, the neuromuscular blocking properties and cardiovascular effects of the two drugs were compared. With large dose administration of ...

journal_title：British journal of anaesthesia

authors： Rørvik K,Husby P,Gramstad L,Vamnes JS,Bitsch-Larsen L,Koller ME

更新日期：1988-08-01 00:00:00

abstract：:The effect of alfentanil on sympathetic reflexes evoked by supramaximal electrical stimulation of the radial nerve has been observed in five dogs anaesthetized with alpha-chloralose, paralysed with suxamethonium and artificially ventilated. In five dogs during the infusion of alfentanil at a rate of 20 micrograms kg-1...

journal_title：British journal of anaesthesia

authors： Swenzen GO,Chakrabarti MK,Sapsed-Byrne S,Whitwam JG

更新日期：1988-10-01 00:00:00

abstract：:Although most local anaesthetic drugs are generally regarded as vasodilators at their site of injection, they produce systemic effects characterized by increases in peripheral resistance, cardiac output, arterial pressure heart rate. The direct depressive effects of the drugs are counterbalanced by increased sympathet...

journal_title：British journal of anaesthesia

authors： Blair MR

更新日期：1975-02-01 00:00:00

abstract：:Cancer survivorship represents a growing clinical challenge for pain clinicians. The population of cancer survivors is rapidly expanding and many of these patients experience pain as a sequelae of their disease and its treatment. The features, pathophysiology and natural history of some painful conditions observed in ...

journal_title：British journal of anaesthesia

authors： Brown M,Farquhar-Smith P

更新日期：2017-10-01 00:00:00

abstract：:We have determined the effect of pretreatment with mivacurium on the potency of suxamethonium and the effect of prior administration of suxamethonium on the potency of mivacurium. We studied 100 ASA I or II patients during thiopentone-fentanyl-nitrous oxide-isoflurane anaesthesia. Neuromuscular block was recorded as t...

journal_title：British journal of anaesthesia

authors： Naguib M,Abdulatif M,Selim M,al-Ghamdi A

更新日期：1995-01-01 00:00:00

abstract：:Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume...

journal_title：British journal of anaesthesia

authors： Cruickshank RH,Morrison DA,Bamber PA,Nimmo WS

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Propofol can scavenge free radicals because it has a chemical structure similar to antioxidants. METHODS:We examined if free radical scavenging occurs with propofol during CABG operations. We studied 24 patients undergoing CABG surgery for triple vessel disease, randomized into two groups. After induction o...

journal_title：British journal of anaesthesia

authors： Sayin MM,Ozatamer O,Taşöz R,Kilinç K,Unal N

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The inhibitory effect of anaesthetic agents on hypoxic pulmonary vasoconstriction may depend upon their dose, especially when using a volatile agent. The aim of this randomized open study was to compare the effects of sevoflurane and propofol, as primary anaesthetic agents, on oxygenation during one-lung ven...

journal_title：British journal of anaesthesia

authors： Pruszkowski O,Dalibon N,Moutafis M,Jugan E,Law-Koune JD,Laloë PA,Fischler M

更新日期：2007-04-01 00:00:00

abstract：:We have studied the effects of alfentanil administered intrathecally on somatosympathetic reflexes evoked by stimulation of radial and tibial nerves in 10 anaesthetized and paralysed dogs. In five animals, alfentanil was administered in doses of 100, 100, 200 and 400 micrograms in 0.8 ml and 800 micrograms in 1.6 ml p...

journal_title：British journal of anaesthesia

authors： Wang C,Chakrabarti MK,Whitwam JG

更新日期：1992-05-01 00:00:00