Comparison of large dose of vecuronium with pancuronium for prolonged neuromuscular blockade.

Abstract:

:Dose-duration relationships for vecuronium were determined and the duration of action produced by vecuronium 0.3 mg kg-1 shown to equal that of pancuronium 0.1 mg kg-1. Using these doses, the neuromuscular blocking properties and cardiovascular effects of the two drugs were compared. With large dose administration of vecuronium (0.3 mg kg-1), both the onset time (mean 81 s) and the 25-75% recovery index (mean 13.9 min) were about one-half those associated with pancuronium (mean 168.5 s and 29.3 min, respectively). The duration of action until 25% recovery was similar with both drugs. There was no evidence of cardiovascular instability with the large dose of vecuronium. Heart rate, however, was significantly slower (range 89.7-94.2% of control) 2-20 min after the injection of vecuronium. Vecuronium 0.3 mg kg-1 may have more favourable neuromuscular blocking effects than pancuronium 0.1 mg kg-1 and may be preferable to pancuronium when prolonged neuromuscular blockade is required.

journal_name

Br J Anaesth

authors

Rørvik K,Husby P,Gramstad L,Vamnes JS,Bitsch-Larsen L,Koller ME

doi

10.1093/bja/61.2.180

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

180-5

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)49348-2

journal_volume

61

pub_type

临床试验,杂志文章,随机对照试验
  • Incidence of venous gas embolism during robotic-assisted laparoscopic radical prostatectomy is lower than that during radical retropubic prostatectomy.

    abstract:BACKGROUND:Robotic-assisted laparoscopic radical prostatectomy (RALRP) is gaining popularity as a less traumatic and minimally invasive alternative to open radical retropubic prostatectomy (RRP). The aim of this study was to evaluate the incidence and grade of venous gas embolism (VGE) during RALRP compared with those ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq247

    authors: Hong JY,Kim JY,Choi YD,Rha KH,Yoon SJ,Kil HK

    更新日期:2010-12-01 00:00:00

  • High frequency jet ventilation v. manual jet ventilation during bronchoscopy in patients with tracheo-bronchial stenosis.

    abstract::Six patients with airway stenosis were submitted to bronchoscopy under general anaesthesia. Each was ventilated with a gas mixture of 50% oxygen and nitrogen using successively manual jet insufflation (JV) using the Sanders technique at 20 b.p.m., and high frequency jet ventilation (HFJV) at rates of 150, 300 and 500 ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/55.10.969

    authors: Vourc'h G,Fischler M,Michon F,Melchior JC,Seigneur F

    更新日期:1983-10-01 00:00:00

  • Regurgitation of gastric contents during general anaesthesia using the laryngeal mask airway.

    abstract::We have investigated the incidence of regurgitation of gastric contents during general anaesthesia administered via a laryngeal mask airway (LMA) or face mask and Guedel airway in 56 patients with no risk factors for regurgitation. Patients swallowed a gelatin capsule containing methylene blue 10 min before induction ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.3.314

    authors: Barker P,Langton JA,Murphy PJ,Rowbotham DJ

    更新日期:1992-09-01 00:00:00

  • Collaborative study of the frequency of the fluoride-resistant cholinesterase variant in patients with malignant hyperpyrexia.

    abstract::Cholinesterase phenotyping studies have been carried out in two laboratories on blood specimens from 28 patients shown to be susceptible to malignant hyperpyrexia. In contrast to previously published reports, no evidence could be found for an increase in the frequency of the E1u E1f genotype above that known to occur ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.3.245

    authors: Evans RT,Iqbal J,Ellis FR,Halsall PJ,Dietz AA,Lubrano T,Rubinstein HM

    更新日期:1981-03-01 00:00:00

  • Regional anaesthesia and analgesia: relationship to cancer recurrence and survival.

    abstract::Cancer treatment is associated with significant morbidity and mortality. Surgery is a mainstay of treatment for many tumours, and anaesthetists care for cancer patients on a daily basis. Surgery itself induces a stress response and inhibits the immune system, and cancer surgery is associated with the release of tumour...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aev375

    authors: Tedore T

    更新日期:2015-12-01 00:00:00

  • Validity and reliability of a postoperative quality of recovery score: the QoR-40.

    abstract::Quality of recovery after anaesthesia is an important measure of the early postoperative health status of patients. We attempted to develop a valid, reliable and responsive measure of quality of recovery after anaesthesia and surgery. We studied 160 patients and asked them to rate postoperative recovery using three me...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.bja.a013366

    authors: Myles PS,Weitkamp B,Jones K,Melick J,Hensen S

    更新日期:2000-01-01 00:00:00

  • Synergistic interaction between midazolam and propofol.

    abstract::We gave either midazolam or propofol for induction of anaesthesia to 140 ASA I or II female patients (18-60 yr). ED50 values were obtained by probit analysis for three clinical end-points: loss of response to command; loss of eyelash reflex; failure to respond to application of an anaesthetic face mask delivering 1% i...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/69.3.240

    authors: McClune S,McKay AC,Wright PM,Patterson CC,Clarke RS

    更新日期:1992-09-01 00:00:00

  • Differential effects of neuromuscular blocking agents on suxamethonium-induced fasciculations and myalgia.

    abstract::The effect of pretreatment with suxamethonium, gallamine or pancuronium on suxamethonium-induced fasciculations and myalgia was studied in a controlled, randomized and double-blind clinical trial. Both fasciculations and myalgia were assessed on a four-point rating scale. There was no significant correlation between f...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/60.4.367

    authors: O'Sullivan EP,Williams NE,Calvey TN

    更新日期:1988-03-01 00:00:00

  • Studies on morphine disposition: influence of general anaesthesia on plasma concentrations of morphine and its metabolites.

    abstract::The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/62.1.22

    authors: Sear JW,Hand CW,Moore RA,McQuay HJ

    更新日期:1989-01-01 00:00:00

  • Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation.

    abstract:BACKGROUND:The second gas effect (SGE) is considered to be significant only during periods of large volume N(2)O uptake (VN(2)O); however, the SGE of small VN(2)O has not been studied. We hypothesized that the SGE of N(2)O on sevoflurane would become less pronounced when sevoflurane administration is started 60 min aft...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/ael008

    authors: Hendrickx JF,Carette R,Lemmens HJ,De Wolf AM

    更新日期:2006-03-01 00:00:00

  • Four phases of intravenous fluid therapy: a conceptual model.

    abstract::I.V. fluid therapy plays a fundamental role in the management of hospitalized patients. While the correct use of i.v. fluids can be lifesaving, recent literature demonstrates that fluid therapy is not without risks. Indeed, the use of certain types and volumes of fluid can increase the risk of harm, and even death, in...

    journal_title:British journal of anaesthesia

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1093/bja/aeu300

    authors: Hoste EA,Maitland K,Brudney CS,Mehta R,Vincent JL,Yates D,Kellum JA,Mythen MG,Shaw AD,ADQI XII Investigators Group.

    更新日期:2014-11-01 00:00:00

  • Comparison of the effectiveness of bilateral ilioinguinal nerve block and wound infiltration for postoperative analgesia after caesarean section.

    abstract::We have studied the effects of bilateral ilioinguinal nerve block and wound infiltration with 0.5% bupivacaine on postoperative pain and analgesic requirements in 62 patients undergoing Caesarean section under general anaesthesia. A control group received no local anaesthetic supplementation. Both ilioinguinal block a...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/72.2.229

    authors: Ganta R,Samra SK,Maddineni VR,Furness G

    更新日期:1994-02-01 00:00:00

  • Quantitative assessment of extradural bupivacaine analgesia.

    abstract::Bupivacaine (0.5%) 20 ml was administered extradurally to six healthy volunteers. It was found that simultaneous application of 10 needles to the skin could evoke pain when analgesia was obtained to one needle stimulation. In addition, a laser beam was used as a quantitative technique to activate simultaneously many c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/65.5.633

    authors: Adrendt-Nielsen L,Oberg B,Bjerring P

    更新日期:1990-11-01 00:00:00

  • Intravenous dexamethasone fails to prolong psoas compartment block when assessed by objective pinprick sensory testing: a prospective, randomised, dose-dependent, placebo-controlled equivalency trial.

    abstract:BACKGROUND:Recent studies have concluded that i.v. dexamethasone can prolong the duration of peripheral nerve blockade. We hypothesized that a 4 mg dose would equally prolong the duration of psoas compartment blocks (PCBs) when compared with 8 mg, and that both doses would prolong the duration when compared with placeb...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bja.2017.11.073

    authors: Turner JD,Dobson SW,Weller RS,Russell GB,Henshaw DS

    更新日期:2018-02-01 00:00:00

  • Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter.

    abstract::Chlorhexidine allergy has been described in the literature, mainly in Japanese individuals. Most reactions have been limited to the skin, mild in severity and a result of chlorhexidine containing solutions such as 'Savlon' (Novartis Consumer Health, Horesham, UK). We describe what we believe is the first reported case...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/87.2.306

    authors: Stephens R,Mythen M,Kallis P,Davies DW,Egner W,Rickards A

    更新日期:2001-08-01 00:00:00

  • Increase in tracheal pressure during jet ventilation.

    abstract::Gas injection systems used in several techniques of ventilation cause increases in airway pressure and physiological changes which are frequently overlooked. The momentum flux theory describes such phenomena most appropriately. We have defined and measured the characteristics of such increases in airway pressure, usin...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/63.7.71

    authors: Isabey D,Boussignac G,Harf A

    更新日期:1989-01-01 00:00:00

  • Sedation of children requiring artificial ventilation using an infusion of midazolam.

    abstract::The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubocurarine). Sedation for patients breathing spontaneously with positive airway pressure was conti...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.10.1104

    authors: Booker PD,Beechey A,Lloyd-Thomas AR

    更新日期:1986-10-01 00:00:00

  • Ventilator problems caused by humidity in the air supplied from simple compressors.

    abstract::Relative humidity of air produced by simple compressors used to drive ventilators was measured at different working pressures. At normal working pressures, a relative humidity of 100% was found and condensation occurred, mainly at the high pressure air/oxygen mixer valve. This resulted in blockages and loss of accurac...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.5.549

    authors: Conely JI,Railton R,MacKenzie AI

    更新日期:1981-05-01 00:00:00

  • Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass.

    abstract::Clevidipine is a new vascular-selective, calcium channel antagonist of the dihydropyridine type with an ester side chain susceptible to esterase metabolism. In healthy volunteers, it has high clearance (0.069 litres min-1 kg-1) with a small volume of distribution at steady state (0.19 litres kg-1). The half-lives of t...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/85.5.683

    authors: Vuylsteke A,Milner Q,Ericsson H,Mur D,Dunning J,Jolin-Mellgård A,Nordlander M,Latimer R

    更新日期:2000-11-01 00:00:00

  • Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study.

    abstract:BACKGROUND:This study aimed to investigate whether reversal of rocuronium-induced neuromuscular blockade with sugammadex reduced the incidence of residual blockade and facilitated operating room discharge readiness. METHODS:Adult patients undergoing abdominal surgery received rocuronium, followed by randomized allocat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev104

    authors: Brueckmann B,Sasaki N,Grobara P,Li MK,Woo T,de Bie J,Maktabi M,Lee J,Kwo J,Pino R,Sabouri AS,McGovern F,Staehr-Rye AK,Eikermann M

    更新日期:2015-11-01 00:00:00

  • Insufficient venous drainage following axillary approach to brachial plexus blockade.

    abstract::Progressive obstruction of an axillary vein following an axillary approach to brachial plexus blockade is described. At surgical exploration, the axillary vein was narrowed with an aneurysm of its wall. It is likely that, during the performance of the block, the needle penetrated the adventitia of the vein, causing a ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.9.1051

    authors: Restelli L,Pinciroli D,Conoscente F,Cammelli F

    更新日期:1984-09-01 00:00:00

  • Retraction notice to "Monitoring of neuromuscular block after administration of vecuronium in patients with diabetes mellitus" [Br J Anaesth 2003; 90: 480-486].

    abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief of British Journal of Anaesthesia. The study is retracted for the following reasons: Statistical analysis suggests t...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,撤回出版物

    doi:10.1016/j.bja.2018.11.007

    authors: Saitoh Y,Kaneda K,Hattori H,Nakajima H,Murakawa M

    更新日期:2019-01-01 00:00:00

  • Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.

    abstract:BACKGROUND:Perioperative neurocognitive disorders (PND) result in long-term morbidity and mortality with no effective interventions available. Because interleukin-6 (IL-6), a pro-inflammatory cytokine, is consistently up-regulated by trauma, including after surgery, we determined whether IL-6 is a putative therapeutic ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2017.11.096

    authors: Hu J,Feng X,Valdearcos M,Lutrin D,Uchida Y,Koliwad SK,Maze M

    更新日期:2018-03-01 00:00:00

  • Effects of morphine on atrial preparations obtained from nonfailing and failing human hearts.

    abstract::We have examined the effects of morphine in auricular myocardium from non-failing and failing human hearts. In both preparations morphine induced inhibition. These responses were not antagonized by naloxone. Comparison of mean IC30 values obtained in non-failing (3.9 (SEM 0.2) x 10(-8) mol litre-1) and failing (5010 (...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.1.106

    authors: Llobel F,Laorden ML

    更新日期:1996-01-01 00:00:00

  • Pharmacokinetics of lignocaine in children after infiltration for cleft palate surgery.

    abstract::We have studied the pharmacokinetics of lignocaine in children after local infiltration for cleft palate surgery. After induction of anaesthesia, lignocaine 2.5 mg kg-1 with adrenaline 1:200,000 was injected into the palate. Blood samples were collected before and at 2, 5, 10, 15, 20, 30, 60 and 120 min after infiltra...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.6.577

    authors: Michael S,Barker I,Henderson P,Griffiths RW,Reilly CS

    更新日期:1992-12-01 00:00:00

  • Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch.

    abstract::Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza™) was recently approved in the EU a...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aer260

    authors: Anand P,Bley K

    更新日期:2011-10-01 00:00:00

  • LiDCO-based fluid management in patients undergoing hip fracture surgery under spinal anaesthesia: a randomized trial and systematic review.

    abstract:BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aeu386

    authors: Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

    更新日期:2015-03-01 00:00:00

  • Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.

    abstract:BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aeu137

    authors: Fletcher D,Martinez V

    更新日期:2014-06-01 00:00:00

  • A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery.

    abstract::The effects of i.m. dexmedetomidine 1.0 micrograms kg-1, a new alpha 2-adrenoceptor agonist, were compared with those of i.m. midazolam 0.08 mg kg-1 and placebo on vigilance, anaesthetic requirements, haemodynamic state and plasma catecholamine concentrations in a double-blind placebo-controlled study in 107 healthy (...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/67.4.402

    authors: Aantaa R,Jaakola ML,Kallio A,Kanto J,Scheinin M,Vuorinen J

    更新日期:1991-10-01 00:00:00

  • Performance of proportional and continuous nitric oxide delivery systems during pressure- and volume-controlled ventilation.

    abstract::We have evaluated the effect of delivering nitric oxide using a continuous flow system (CFS) or two commercially available proportional gas injection systems (PGIS), Nodomo (Dräger, Lübeck, Germany) and Pulmonox-Mini (Messer Griesheim Austria, Gumpoldskirchen, Austria) on measured and simulated concentrations of nitri...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/81.4.544

    authors: Hiesmayr MJ,Neugebauer T,Lassnigg A,Steltzer H,Haider W,Gilly H

    更新日期:1998-10-01 00:00:00