Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass.

abstract：:Liver/gas partition coefficients for isoflurane, enflurane, halothane and methoxyflurane increased two-fold in rats killed 16 h after a single injection of 15% ethanol 7 g kg-1. In contrast, blood/gas and brain/gas partition coefficients did not change. Chronic (21 days) ingestion of ethanol increased liver/gas partit...

journal_title：British journal of anaesthesia

authors： Fassoulaki A,Eger EI 2nd

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:The role of repeated prone positioning in intubated subjects with acute respiratory distress syndrome caused by COVID-19 remains unclear. METHODS:We conducted a retrospective observational cohort study of critically ill intubated patients with COVID-19 who were placed in the prone position between March 18,...

journal_title：British journal of anaesthesia

authors： Weiss TT,Cerda F,Scott JB,Kaur R,Sungurlu S,Mirza SH,Alolaiwat AA,Kaur R,Augustynovich AE,Li J

更新日期：2021-01-01 00:00:00

abstract：:A 39-year-old male suffered a closed chest deceleration injury. He presented with clinical and radiological signs consistent with trauma to the thoracic aorta, but also developed sinus bradycardia which was relieved by drainage of a haemothorax. The possible mechanisms of the changes in heart rate are discussed and di...

journal_title：British journal of anaesthesia

authors： Kong RS,Wood PR

更新日期：1994-03-01 00:00:00

abstract：:A recently installed anti-pollution system, initially designed to function in a passive mode, was evaluated, but found to be inconstant in its performance. A simple method of making the system active is described and evaluated. ...

journal_title：British journal of anaesthesia

authors： Asbury AJ,Hancox AJ

更新日期：1977-05-01 00:00:00

abstract：:To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...

journal_title：British journal of anaesthesia

authors： Ray DC,Bomont R,Mizushima A,Kugimiya T,Forbes Howie A,Beckett GJ

更新日期：1996-09-01 00:00:00

abstract：:The effect of incubation at 37 degrees C, 46 degrees C, 47 degrees C and 48 degrees C for 1 h on the osmotic fragility of blood was determined. Blood taken from volunteers into ACD and CPD was examined after 1, 7, 14 and 21 days of storage. In addition, 22-day-old blood stored in CPD was examined. The osmotic fragilit...

journal_title：British journal of anaesthesia

authors： Van der Walt JH,Russell WJ

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Fast onset and short duration are prominent properties of the amide-type local anaesthetic articaine. Similar to bupivacaine, a hyperbaric solution of articaine may produce faster onset and shorter duration of spinal anaesthesia than a plain solution. METHODS:Patients undergoing open inguinal hernia repair ...

journal_title：British journal of anaesthesia

authors： Bachmann M,Pere P,Kairaluoma P,Rosenberg PH,Kallio H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or appare...

journal_title：British journal of anaesthesia

authors： Dahan A,Yassen A,Romberg R,Sarton E,Teppema L,Olofsen E,Danhof M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Cyclic redistribution of air within the cuff during respiratory pressure changes creates a self-sealing mechanism which allows tracheal sealing, despite tracheal airway pressure being above baseline cuff inflation pressure. The aim of the present study was to investigate the effect of continuous automated cu...

journal_title：British journal of anaesthesia

authors： Weiss M,Doell C,Koepfer N,Madjdpour C,Woitzek K,Bernet V

更新日期：2009-02-01 00:00:00

abstract：:Intrathecal midazolam causes antinociception by combining with spinal cord benzodiazepine receptors. This effect is reversible with doses of naloxone, suggesting involvement of spinal kappa or delta but not mu opioid receptors. The antinociceptive effects of intrathecally administered drugs in the spinal cord were dem...

journal_title：British journal of anaesthesia

authors： Goodchild CS,Guo Z,Musgreave A,Gent JP

更新日期：1996-12-01 00:00:00

abstract：:The oxygen delivery (DO2) and consumption (VO2) relationship in brain-dead organ donors is unknown. Therefore, in a prospective study, we determined the DO2/VO2 relationship in 21 consecutive brain-dead patients. Patients were allocated to one of two groups, according to plasma lactate concentration: normal (group NL,...

journal_title：British journal of anaesthesia

authors： Langeron O,Couture P,Mateo J,Riou B,Pansard JL,Coriat P

更新日期：1996-06-01 00:00:00

abstract：:In the dog, pancuronium 0.2 mg/kg increased left ventricular systolic pressure and systemic arterial pressure, but did not change central venous pressure. Repeated doses produced diminishing responses and eventually no change in arterial pressure. After tachyphylaxis was established, a pressor response to pancuronium ...

journal_title：British journal of anaesthesia

authors： Domenech JS,Garcia RC,Sastain JM,Loyola AQ,Oroz JS

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Double-lumen tubes (DLTs) are frequently used to establish one-lung ventilation (OLV). Their correct placement is crucial. We hypothesized that electrical impedance tomography (EIT) reliably displays distribution of ventilation between left and right lung and may thus be used to verify correct DLT placement ...

journal_title：British journal of anaesthesia

authors： Steinmann D,Stahl CA,Minner J,Schumann S,Loop T,Kirschbaum A,Priebe HJ,Guttmann J

更新日期：2008-09-01 00:00:00

abstract：:We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or...

journal_title：British journal of anaesthesia

authors： Ilkjaer S,Nikolajsen L,Hansen TM,Wernberg M,Brennum J,Dahl JB

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...

journal_title：British journal of anaesthesia

authors： Buzançais G,Roger C,Bastide S,Jeannes P,Lefrant JY,Muller L

更新日期：2016-02-01 00:00:00

abstract：:A randomized, double-blind study of 40 women was performed to compare patient controlled anaesthesia (PCA) morphine requirements after spinal anaesthesia for elective Caesarean section. The women received 0.2 mg of either morphine or diamorphine mixed with 0.5% bupivacaine in 8% dextrose. There were no significant dif...

journal_title：British journal of anaesthesia

authors： Husaini SW,Russell IF

更新日期：1998-08-01 00:00:00

abstract：Background.:Perioperative administration of cefazolin reduces the incidence of perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 and 5 h after the initial dose. This study was undertaken to determine whether intraoperative continuous infusions of cefazolin achieve better probab...

journal_title：British journal of anaesthesia

authors： Naik BI,Roger C,Ikeda K,Todorovic MS,Wallis SC,Lipman J,Roberts JA

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Inconsistent and poorly coordinated systems of tracheostomy care commonly result in frustrations, delays, and harm. Quality improvement strategies described by exemplar hospitals of the Global Tracheostomy Collaborative have potential to mitigate such problems. This 3 yr guided implementation programme inves...

journal_title：British journal of anaesthesia

authors： McGrath BA,Wallace S,Lynch J,Bonvento B,Coe B,Owen A,Firn M,Brenner MJ,Edwards E,Finch TL,Cameron T,Narula A,Roberson DW

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:We studied the potential neuroprotective effects of halothane and desflurane, compared with the awake state, on infarct size following 2 h of intraluminal middle cerebral artery occlusion (MCAo) and 22 h of reperfusion. METHODS:Male Sprague-Dawley rats were anaesthetized with desflurane or halothane, intuba...

journal_title：British journal of anaesthesia

authors： Haelewyn B,Yvon A,Hanouz JL,MacKenzie ET,Ducouret P,Gérard JL,Roussel S

更新日期：2003-09-01 00:00:00

abstract：:We describe the anaesthetic management of a patient who underwent transthoracic endoscopic vagotomy. One-lung ventilation was necessary to provide adequate surgical access. Potential intraoperative problems involved arterial oxygen saturation during one-lung ventilation, unequal intrathoracic pressures causing mediast...

journal_title：British journal of anaesthesia

authors： Chui PT,Gin T,Chung SC

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Current guidelines for perioperative management of coronavirus disease 19 (COVID-19) are mainly based on extrapolated evidence or expert opinion. We aimed to systematically investigate how COVID-19 affects perioperative management and clinical outcomes, to develop evidence-based guidelines. METHODS:First, w...

journal_title：British journal of anaesthesia

authors： Zheng H,Hébert HL,Chatziperi A,Meng W,Smith BH,Yan J,Zhou Z,Zhang X,Luo A,Wang L,Zhu W,Hu J,Colvin LA

更新日期：2020-12-01 00:00:00

abstract：:A 4-year-old girl developed severe hepatitis following the fourth administration of halothane in a period of 5 months. She was shown to have a circulating antibody which acted specifically against rabbit hepatocyte previously sensitized to halothane. The patient made a full recovery from the hepatitis, but 5 months la...

journal_title：British journal of anaesthesia

authors： Lewis RB,Blair M

更新日期：1982-03-01 00:00:00

abstract：:The problems of selection of tracheal tubes, and the need for a rationale, are outlined. Tracheal tubes of 7.5 mm and 8.5 mm i.d. are recommended for female and male patients, respectively. Tracheal size was determined using high pressure-low volume cuffs as measuring devices. The average diameter of the cuff at seal ...

journal_title：British journal of anaesthesia

authors： Chandler M,Crawley BE

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:There is growing interest in the effect of postoperative analgesics on oncological outcomes after cancer surgery. We investigated the impact of tramadol after breast cancer surgery on recurrence and mortality and explored the mechanism by which tramadol affects cultured breast cancer cells in vitro. METHODS...

journal_title：British journal of anaesthesia

authors： Kim MH,Oh JE,Park S,Kim JH,Lee KY,Bai SJ,Song H,Hwang HJ,Kim DW,Yoo YC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explore difficulties at work from anaesthetists' own perspective and to examine how anaesthetists handle and cope with situations that are perceived as difficult and potentially stressful. METHODS:Two sets of interviews were conducted with 19 specialist anaesthetists in Sweden. ...

journal_title：British journal of anaesthesia

authors： Larsson J,Rosenqvist U,Holmström I

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) monitor has been suggested as a potential tool to measure depth of sedation in paediatric intensive care unit (PICU) patients. The primary aim of our observational study was to assess the difference in BIS values between the left and right sides of the brain. Secondary aims were to...

journal_title：British journal of anaesthesia

authors： Froom SR,Malan CA,Mecklenburgh JS,Price M,Chawathe MS,Hall JE,Goodwin N

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:There are regional differences in the effects of anaesthetics agents and perioperative stimuli on the EEG. We studied the topography of the EEG during induction of anaesthesia and intubation in patients receiving thiopental and fentanyl to document regional electrical brain activity. METHODS:EEG was recorde...

journal_title：British journal of anaesthesia

authors： Rundshagen I,Schröder T,Prichep LS,John ER,Kox WJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

journal_title：British journal of anaesthesia

authors： Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

更新日期：2015-03-01 00:00:00

abstract：:The retention of nitrous oxide in samples of nitrous oxide in air held in disposable plastic syringes, glass syringes and custom-made nylon film bags was studied by means of gas chromatography at intervals of 90 min, 24, 48 and 120 h after filling the containers. After 24 h the nylon bags retained a mean concentration...

journal_title：British journal of anaesthesia

authors： Austin JC,Shaw R,Crichton R,Cleaton-Jones PE,Moyes D

更新日期：1978-11-01 00:00:00

abstract：:The performance of a fuzzy controller for atracurium-induced neuromuscular block was assessed. Ten ASA I or II patients undergoing surgery anticipated to last at least 120 min were studied. A Datex Relaxograph was used to monitor neuromuscular block. Initially the T1 set point was set at 10% of baseline for at least 3...

journal_title：British journal of anaesthesia

authors： Mason DG,Edwards ND,Linkens DA,Reilly CS

更新日期：1996-03-01 00:00:00