Abstract：
:We have examined the correlation between the evoked electromyographic response in the first dorsal interosseous muscle of the hand, temperature and forearm position in 40 female patients after enflurane anaesthesia with spontaneous breathing. In 20 patients the supinated forearm with the wrist extended was immobilized on an armboard with adhesive tape (group A). In the other 20 patients (group B), the hand was strapped into a fist with adhesive tape and laid supine on an armboard. During the 30 min after induction of anaesthesia, the mean response to the first stimulus in the train-of-four was the same in both groups and decreased from a baseline value of 99.7% (95% confidence interval (CI) 99.1-100.4%) to 86.2% (95% CI 83.3-89.0%). The final response was less than 90% of baseline in 28 patients. There was an inverse linear correlation between the electromyographic response and both skin and muscle temperature in both groups (r > 0.98), although there was no correlation between change in the electromyogram and change in temperature (r < -0.26). After 30 min, pronation of the forearm resulted in a further decrease in the electromyographic response in 13 of 18 patients in group B (two patients in this group were excluded from analysis). Pressure was then applied to the scaphoid tubercles of all patients to produce maximal supination of the forearm. This had no effect on the electromyogram in 10 patients. In 28 patients the electromyographic response increased after scaphoid pressure, although it remained 90% of baseline in five patients. The measured temperatures did not alter during these manoeuvres.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Smith DC,Booth JVdoi
10.1093/bja/72.4.407subject
Has Abstractpub_date
1994-04-01 00:00:00pages
407-10issue
4eissn
0007-0912issn
1471-6771pii
S0007-0912(17)44491-6journal_volume
72pub_type
临床试验,杂志文章,随机对照试验abstract：:The neuromuscular and cardiovascular effects of atracurium were compared during nitrous oxide-isoflurane and nitrous oxide-fentanyl anaesthesia in healthy surgical patients. The dose-response curve was shifted significantly to the left during nitrous oxide-isoflurane anaesthesia (ED50 0.068 mg kg-1) as compared with n...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza™) was recently approved in the EU a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aer260
更新日期：2011-10-01 00:00:00
abstract：:We studied 40 elderly patients undergoing cataract surgery. Ten non-insulin-dependent diabetes mellitus (NIDDM) patients received standardized general anaesthesia, 10 NIDDM patients received local anaesthesia using retrobulbar block, 10 non-diabetic control patients received general anaesthesia and 10 non-diabetic con...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/74.5.500
更新日期：1995-05-01 00:00:00
abstract：:We have examined the effects of two types of insulin therapy (continuous i.v. infusion (group A: 1.25 u. h-1) and direct i.v. bolus administration of 10 u. every 2 h (group B: 10 u./2 h)) on the metabolic and endocrine responses to surgery in 60 adult diabetic patients undergoing general anaesthesia for elective proce...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/72.1.5
更新日期：1994-01-01 00:00:00
abstract：:Prolongation of the QT interval of the ECG represents an imbalance in cardiac autonomic function and may predict cardiac arrhythmia. Vagal activity protects against prolongation of the QT interval which may be associated with flattening of the T-wave of the ECG. The changes in QT interval, T-wave amplitude and respira...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.5.736
更新日期：1993-11-01 00:00:00
abstract：:We have studied the effect of doxapram on the rates of spontaneous and neostigmine-induced recovery from neuromuscular block with atracurium and vecuronium, by measurement of the time to recovery of T1 (first twitch in the train-of-four) from 25 to 75% of control (recovery index, RI). After each neuromuscular blocking...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.5.527
更新日期：1992-05-01 00:00:00
abstract：:In our daily anaesthetic practice, we are confronted with an increasing number of patients treated with either antiplatelet or anticoagulant agents. During the last decade, changes have occurred that make the handling of antithrombotic medication a challenging part of anaesthetic perioperative management. In this revi...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aew214
更新日期：2016-09-01 00:00:00
abstract：:The effects of bolus doses of phenoperidine 1-2 mg i.v. either alone, or combined with pancuronium 2-4 mg, were investigated in seven patients in traumatic coma. Phenoperidine alone significantly reduced mean arterial pressure (MAP) by a mean (+/- SEM) of 13.2 (+/- 2.8) mm Hg. Overall there was no significant change i...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.5.592
更新日期：1987-05-01 00:00:00
abstract：:The rapid detection and evaluation of patients presenting with perioperative neurological dysfunction is of great clinical relevance. Biomarkers have been defined as biological molecules that can be used as an indicator of new onset or progression of a biological process or effect of treatment. Biomarkers have become ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aer338
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The ability of the third-generation FloTrac/Vigileo software to track changes in cardiac index (CI) induced by volume expansion and norepinephrine in critically ill patients is unknown. METHODS:In subjects with circulatory failure, we administered volume expansion (20 subjects) and increased (20 subjects) o...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aer491
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The perioperative management of two-stage oesophagectomy has not been standardized and the prevailing practice regarding the timing of extubation after the procedure varies. This audit has evaluated the outcome, in particular the respiratory morbidity and mortality, after immediate extubation in patients who...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg091
更新日期：2003-04-01 00:00:00
abstract：:Thiopental is a racemate of equimolar R- and S-thiopental enantiomers that have different potencies in laboratory experiments. We measured concentrations of R- and S-thiopental in plasma, tissues and brain microdialysate of rats after computer-controlled infusion of thiopental i.v. to a plasma concentration of 40 micr...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/oxfordjournals.bja.a013385
更新日期：2000-01-01 00:00:00
abstract：:We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/82.1.132
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:There is considerable evidence that the use of tidal volumes <6 ml kg(-1) predicted body weight (PBW) reduces mortality in mechanically ventilated patients. We evaluated the effectiveness of using a large screen displaying delivered tidal volume in ml kg(-1) (PBW) for reducing tidal volumes. METHODS:We asse...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aev110
更新日期：2015-08-01 00:00:00
abstract：:We have used mivacurium in four myasthenic patients presenting for thymectomy. Supramaximal single twitch stimulation was applied to the ulnar nerve at the wrist and the force of contraction of the adductor pollicis was measured. After an initial bolus dose of 30 micrograms kg-1 (approximately one-fifth of the normal ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/73.4.494
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:The pathophysiology of the serotoninergic system in malignant hyperthermia (MH) is not completely understood. The serotonin-2 (5HT(2A)) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI) induces typical MH symptoms, including skeletal muscle rigidity, an increase in body tempe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg172
更新日期：2003-08-01 00:00:00
abstract：:The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaesthesia in 57 patients premedicated with morphine sulphate 0.15 mg kg-1. Anaesthesia was induced with propofol 2 mg kg-1, and maintained before incision with a fixed-rate...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.10.1080
更新日期：1986-10-01 00:00:00
abstract：:Five hundred and seventeen women in labour receiving extradural analgesia, using bupivacaine plain solution, were randomly allocated to one of three groups. Group A received 6-8ml of 0.5% solution, group B 10-14ml of 0.25% solution, and group C 6-8 ml of 0.25% solution. Spontaneous delivery occurred in 31.7% of patien...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/53.9.933
更新日期：1981-09-01 00:00:00
abstract：:Chloral hydrate 25, 50 or 75 mg kg-1 or midazolam 0.4, 0.5 or 0.6 mg kg-1, all given by mouth in combination with atropine 0.03 mg kg-1, were compared as premedication in 248 children in a randomized, double-blind study. Chloral hydrate was significantly less palatable than midazolam. The anxiolytic effect of chloral ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/61.4.390
更新日期：1988-10-01 00:00:00
abstract：:Loss of resistance dorsal to the ligamentum flavum was recorded in 10 of 16 patients aged 43--75 yr whilst performing extradural anaesthesia at the L2--3 interspace via the midline approach. Degeneration of the interspinous ligament with cavity formation is observed frequently in the elderly and may account for false ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/51.3.253
更新日期：1979-03-01 00:00:00
abstract：:We have studied the pharmacokinetics of lignocaine in children after local infiltration for cleft palate surgery. After induction of anaesthesia, lignocaine 2.5 mg kg-1 with adrenaline 1:200,000 was injected into the palate. Blood samples were collected before and at 2, 5, 10, 15, 20, 30, 60 and 120 min after infiltra...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/69.6.577
更新日期：1992-12-01 00:00:00
abstract：:This study was designed to determine whether dextran, gelatin or hydroxyethyl starch-based colloidal resuscitation fluids (CRF) are inhibitory to T lymphocyte activation and mitogenesis in vitro. Isolated peripheral blood lymphocytes from normal donors were activated with mitogen (PHA) and cultured in up to 50% v:v CR...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/81.2.242
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:The molecular actions underlying the clinical effects of inhaled anaesthetics such as sevoflurane and isoflurane are not fully understood. Unexpected observations in positron emission tomography (PET) studies with [11C]AZD9272, a metabotropic glutamate receptor 5 (mGluR5) radioligand with possible affinity f...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.08.052
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The effect of anaesthetic drugs on long-term oncological outcomes after cancer surgery is an area of current interest. Dexamethasone is widely used in anaesthetic practice; however, its effect on long-term survival and cancer outcomes is not known. This study presents the results of a 5-yr follow-up of patie...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aet577
更新日期：2014-07-01 00:00:00
abstract：:In a prospective study, patients undergoing abdominal surgery were allocated randomly to receive intermittent morphine 10 mg i.m. (n = 41) or a single injection of buprenorphine 0.3 mg i.m. followed by sublingual buprenorphine 0.4 mg every 6 h (n = 39) for 3 days following operation. Patients receiving buprenorphine w...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/56.8.855
更新日期：1984-08-01 00:00:00
abstract：:A double-blind randomized trial was conducted to compare etidocaine, the new local anaesthetic agent, with bupivacaine. One hundred patients were each given a single dose of one of the drugs during the surgical induction of labour. The results showed that etidocaine had a quicker onset of action than bupivacaine, but ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/47.12.1305
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:Serum vascular endothelial growth factor-C (VEGF-C), transforming growth factor-β (TGF-β), and interleukin (IL)-6 promote angiogenesis and metastases in colon cancer. We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-β, and IL-6 and an incre...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aeu148
更新日期：2014-07-01 00:00:00
abstract：:A combination of exogenous surfactant and partial liquid ventilation (PLV) with perfluorocarbons should enhance gas exchange, improve respiratory mechanics and reduce tissue damage of the lung in acute lung injury (ALI). We used a small dose of exogenous surfactant with and without PLV in an experimental model of ALI ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.4.593
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:In regional anaesthesia, there is a risk of direct nerve injury. The purpose of this study was to determine whether the diameter of the applied needle is associated with the magnitude of nerve injury after needle nerve perforation. METHODS:In five anaesthetized pigs, the brachial plexus were exposed bilater...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aep366
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Emotional information has the ability to alter the formation and strength of a memory ('memory modulation'). Memory modulation by negative emotion is mediated by the amygdala. It is not known how gamma aminobutyric acid (GABA)ergic drugs affect the processes involved in memory modulation. This study investig...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/aeh211
更新日期：2004-09-01 00:00:00
