Abstract:
:Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume than administration 3 h before surgery. There was a reduction in the number of patients with a pH of less than 2.5 and a volume of 25 ml or more in the treated groups compared with the combined placebo groups. Omeprazole may have a role in prophylaxis against acid aspiration syndrome.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Cruickshank RH,Morrison DA,Bamber PA,Nimmo WSdoi
10.1093/bja/63.5.536subject
Has Abstractpub_date
1989-11-01 00:00:00pages
536-40issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)38702-0journal_volume
63pub_type
临床试验,杂志文章,随机对照试验abstract::The problems of selection of tracheal tubes, and the need for a rationale, are outlined. Tracheal tubes of 7.5 mm and 8.5 mm i.d. are recommended for female and male patients, respectively. Tracheal size was determined using high pressure-low volume cuffs as measuring devices. The average diameter of the cuff at seal ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/58.1.111
更新日期:1986-01-01 00:00:00
abstract::We have studied the relationship between gas exchange and mechanical frequency response during high frequency jet ventilation (HFJV) at 0.5-5.0 Hz in anaesthetized pigs. The mechanical gain curve showed a minimal "anti-resonant" response at 0.8 Hz (f1) and a maximal "resonant" response at 5.0 Hz (f2). This finding may...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/64.4.453
更新日期:1990-04-01 00:00:00
abstract::The rate of liquid-phase gastric emptying was determined in seven smokers from the rate of paracetamol absorption after abstaining overnight from cigarettes, and again after smoking two cigarettes within 30 min. There were no significant differences between the maximum paracetamol concentration, the time to reach maxi...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/57.11.1104
更新日期:1985-11-01 00:00:00
abstract::Eighteen patients were studied, during operations under subarachnoid or extradural anaesthesia combined with general anaesthesia, to assess the influence of occlusion of inspiration on the duration of inspiration, and the likelihood of a relationship between lung volume and duration of inspiration. Ten patients breath...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/56.3.215
更新日期:1984-03-01 00:00:00
abstract::The determination of blood flow, i.e. cardiac output, is an integral part of haemodynamic monitoring. This is a review on noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. We present the underlying principles and validation data of the following technologies: thoracic elect...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aeu447
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:There has been increasing use of invasive techniques, such as extracorporeal organ support, in intensive care units (ICU), and declining autopsy rates. Thus, new measures are needed to maintain high-quality standards. We investigated the potential of computed tomography (CT)-based virtual autopsy to substitu...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1016/j.bja.2018.02.031
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The effects of thoracic epidural anaesthesia (TEA) on gastric mucosal microvascular haemoglobin oxygenation (microHbO(2)) are unclear. At the splanchnic level, reduction of sympathetic tone may promote vasodilation and increase microHbO(2). However, these splanchnic effects are counteracted by systemic effec...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeh235
更新日期:2004-10-01 00:00:00
abstract::Spinal anaesthesia is the preferred anaesthetic technique for elective Caesarean deliveries. Hypotension is the most common side-effect and has both maternal and neonatal consequences. Different strategies have been attempted to prevent spinal-induced hypotension, including the use of low-dose bupivacaine. We conducte...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,meta分析,评审
doi:10.1093/bja/aer200
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The ability of the third-generation FloTrac/Vigileo software to track changes in cardiac index (CI) induced by volume expansion and norepinephrine in critically ill patients is unknown. METHODS:In subjects with circulatory failure, we administered volume expansion (20 subjects) and increased (20 subjects) o...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aer491
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Moderate to deep sedation has been recommended during endoscopic submucosal dissection (ESD). However, it is often accompanied by adverse events such as respiratory depression or aspiration pneumonia. This study investigated the respiratory complications and ESD outcomes of two sedation protocols: moderate s...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeu555
更新日期:2015-07-01 00:00:00
abstract::Visceromotor responses and vasopressin release before and after colonic visceral distension were compared between male (n=5 (n=4 for vasopressin)) and female rats and between females during the oestrous cycle (proestrus n=6, oestrus n=5, metestrus n=5, diestrus n=6) at a controlled depth of anaesthesia. Pre-stimulatio...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/85.6.907
更新日期:2000-12-01 00:00:00
abstract::Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/48.11.1091
更新日期:1976-11-01 00:00:00
abstract::Critical narrowing of the dependent airways was examined in anaesthetized dogs with closed chests. Two techniques were used, (a) "closing" volume (CV), measured from the expired nitrogen plateau and (b) tantalum bronchography, to measure the calibre of airways of 3-8 mm diameter in the upper (UZ), middle (MZ) and lowe...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/50.8.735
更新日期:1978-08-01 00:00:00
abstract::Bupivacaine is used widely as a local anaesthetic but has potential for severe cardiovascular and central nervous system (CNS) toxicity. It has an asymmetric carbon atom giving it a chiral centre, and the commercial preparation is a racemic mixture of its two enantiomers: dextro or R(+)-bupivacaine and levo or S(-)-bu...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/80.5.594
更新日期:1998-05-01 00:00:00
abstract::Although well established in clinical practice, both propofol and midazolam have limitations. New hypnotics with different and potentially superior pharmacokinetics and pharmacodynamics are under development. These include the benzodiazepine receptor agonists CNS7056 and JM-1232 (-), the etomidate-based methoxycarbony...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aeq190
更新日期:2010-09-01 00:00:00
abstract::The central venous catheter (CVC) is associated with numerous complications more so during the process of insertion. We report for the first time how an indwelling catheter was entrapped by a replacement catheter on the same side, after being speared by the introducer needle and guidewire. The diagnosis was made when ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/ael286
更新日期:2007-01-01 00:00:00
abstract::A case of an infant receiving orthotopic heart transplantation with over-sized donor heart was reported. Left lower pulmonary venous obstruction after sternotomy closure was detected by transoesophageal echocardiography (TOE) and the decision to delay sternal closure was made and the clinical outcome was very satisfac...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/88.4.590
更新日期:2002-04-01 00:00:00
abstract::The concept of rapid delivery of multiple blood products to the bedside of a massively haemorrhaging patient seems to be a logical approach to the management of the massively bleeding patient. However, controversy exists in the use of fixed blood component ratios. Assessing the extent of the coagulopathy through point...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aeu379
更新日期:2014-12-01 00:00:00
abstract::We studied the size 4 laryngeal mask airway (LMA) to test the hypothesis that oropharyngeal leak pressure and fibreoptic position improves with increasing cuff volume. After LMA insertion, 50 anaesthetized adult patients had the cuff inflated in 5-ml increments to 40 ml. Oropharyngeal leak pressure was optimal at 15 m...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/81.2.186
更新日期:1998-08-01 00:00:00
abstract::This study has examined the effect of hydration on immediate recovery from anaesthesia in two groups of 15 patients undergoing therapeutic abortion. A standard anaesthetic technique was administered. Patients in group I received no preoperative fluid; those in group II received, before anaesthesia, 20 ml kg-1 of 4% gl...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章
doi:10.1093/bja/68.6.576
更新日期:1992-06-01 00:00:00
abstract::Anaesthetic and sedative drugs transiently disrupt normal neural activity to facilitate healthcare procedures in children, but they can also cause long-term brain injury in experimental animal models. The US Food and Drug Administration (FDA) has recently advised that repeated or lengthy exposures to anaesthetic and s...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aex141
更新日期:2017-09-01 00:00:00
abstract::The coherent frequency (CF) of the auditory evoked response (AER) is derived using auditory clicks presented at frequencies in the range 5-47 Hz. CF and psychological performance were measured while seven subjects breathed isoflurane in doses increasing from 0% to 0.2%, 0.4% and 0.8% end-tidal concentration and then d...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/71.5.633
更新日期:1993-11-01 00:00:00
abstract::The isolated rat hepatocyte model has been used to assess the hepatotoxicity of a number of i.v. anaesthetic induction agents. Ketamine, Althesin and CCI 12923 (minaxolone) all inhibited gluconeogenesis and urea formation from alanine. There was also a decrease in the cell ATP concentration, and a dose-related increas...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/51.8.733
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aet331
更新日期:2014-02-01 00:00:00
abstract::We have investigated the incidence of regurgitation of gastric contents during general anaesthesia administered via a laryngeal mask airway (LMA) or face mask and Guedel airway in 56 patients with no risk factors for regurgitation. Patients swallowed a gelatin capsule containing methylene blue 10 min before induction ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/69.3.314
更新日期:1992-09-01 00:00:00
abstract::Control measurements of blood flow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steady-state conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to ap...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/57.12.1239
更新日期:1985-12-01 00:00:00
abstract::We have compared mivacurium and succinylcholine in 27 paediatric patients with mild (Child's A) to moderate (Child's B) liver disease undergoing oesophagogastroduodenoscopy (OGD) and injection of oesophageal varices, with 10 healthy children receiving mivacurium for ENT procedures. With mivacurium 0.2 mg kg-1, the sev...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/81.3.463
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:The memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aew421
更新日期:2017-02-01 00:00:00
abstract::Falls are a known public health problem, and there is increasing recognition of the importance of perioperative falls for risk prediction and quality assessment. Our objective was to review existing literature regarding the occurrence, injuries, and risk factors of preoperative and postoperative falls. A systematized ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aew377
更新日期:2016-12-01 00:00:00
abstract::We have investigated the effects of propofol on beat-to-beat fluctuations in heart rate, arterial pressure (continuous arterial tonometry) and infrared finger plethysmography in 10 healthy male patients undergoing elective surgery. Administration of Diprivan (propofol 10 mg ml-1) 0.2 ml kg-1, followed by an infusion o...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/73.2.167
更新日期:1994-08-01 00:00:00