Mivacurium compared with succinylcholine in children with liver disease.

Abstract:

:We have compared mivacurium and succinylcholine in 27 paediatric patients with mild (Child's A) to moderate (Child's B) liver disease undergoing oesophagogastroduodenoscopy (OGD) and injection of oesophageal varices, with 10 healthy children receiving mivacurium for ENT procedures. With mivacurium 0.2 mg kg-1, the severity of liver disease did not correlate with duration of block compared with controls (time from bolus to T1 25%, P = 0.74; T1 25% to T4:T1 > 0.7, P = 0.545). However, initial recovery (time to T1 25%, P = 0.002) and overall recovery (bolus to T4:T1 > 0.7, P = 0.004) from mivacurium-induced neuromuscular block correlated inversely with pre-existing concentrations of plasma cholinesterase. Conditions for tracheal intubation at 2 min with mivacurium were comparable with conditions at 1 min with succinylcholine in the liver patients.

journal_name

Br J Anaesth

authors

Green DW,Fisher M,Sockalingham I

doi

10.1093/bja/81.3.463

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

463-5

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)39613-7

journal_volume

81

pub_type

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