Abstract：
:Bupivacaine is used widely as a local anaesthetic but has potential for severe cardiovascular and central nervous system (CNS) toxicity. It has an asymmetric carbon atom giving it a chiral centre, and the commercial preparation is a racemic mixture of its two enantiomers: dextro or R(+)-bupivacaine and levo or S(-)-bupivacaine. Preclinical studies have demonstrated reduced cardiotoxicity and CNS toxicity for S(-)-bupivacaine. In this study we have compared the clinical efficacy of S(-)-bupivacaine with racemic RS-bupivacaine for supraclavicular brachial plexus block in 75 patients undergoing elective hand surgery. Patients received 0.4 ml kg-1 of either 0.25% or 0.5% S(-)-bupivacaine or 0.5% RS-bupivacaine in a randomized, double-blind study. Clinical assessments of sensory and motor block were performed at regular intervals. There were no significant differences in onset time, dermatomal spread or duration of both sensory and motor block between the three groups (the power of the study was 81% to detect a 4-h difference in duration). Duration of sensory block was prolonged with wide interpatient variation: 892 (SD 250) min, 1039 (317) min and 896 (284) min for 0.25% S(-)-bupivacaine, 0.5% S(-)-bupivacaine and 0.5% RS-bupivacaine, respectively. There were no differences in the overall success rate of the technique. We conclude that S(-)-bupivacaine was suitable for local anaesthetic use in brachial plexus block anaesthesia.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Cox CR,Checketts MR,Mackenzie N,Scott NB,Bannister Jdoi
10.1093/bja/80.5.594subject
Has Abstractpub_date
1998-05-01 00:00:00pages
594-8issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)40421-1journal_volume
80pub_type
临床试验,杂志文章,随机对照试验abstract：:We have studied the efficacy of i.v. clonidine to suppress post-extradural shivering in parturients. Forty healthy parturients who received extradural block for labour (n = 20) or for Caesarean section (n = 20) and who required treatment for shivering after delivery were allocated randomly to two groups. Group I recei...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/71.2.294
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Isoflurane and other volatile anaesthetics have a cardioprotective effect and limit myocardial infarct size to the same extent as ischaemic preconditioning. Phosphatidylinositol-3-kinase (PI3K) was found to play a key role in myocardial protection by ischaemic preconditioning. The aim of the present investig...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aei264
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:We explored whether a previously successful initiative to improve first-case on-time starts succeeded because (i) preoperative steps started earlier (but the process did not necessarily improve) or (ii) the process was brought into better control. METHODS:We analysed 35 months of data comprising 28 882 firs...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2018.05.043
更新日期：2018-11-01 00:00:00
abstract：:Thirty patients for elective lower segment Caesarean section were randomly divided into two groups. One group received 50 mulitre/kg of Althesin for induction of anaesthesia and the other, 100 mulitre/kg. The two maternal groups were similar. There was no significant difference in the clinical or biochemical status of...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/47.11.1213
更新日期：1975-11-01 00:00:00
abstract：:We conducted a prospective, randomized, double-blind study to compare analgesia obtained by wound infiltration using 29 ml of 0.25% bupivacaine alone, or with the addition of clonidine hydrochloride 150 micrograms. A third group received bupivacaine wound infiltration with clonidine 150 micrograms i.m. to control for ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/79.4.446
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Blood flow patterns are important modifiers of platelet interactions with plasma coagulation factors. However, it is not feasible to evaluate rheological effects of haemodilution on coagulation using conventional coagulation testing. METHODS:We evaluated thrombus formation with a microchip-based flow-chambe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet229
更新日期：2013-12-01 00:00:00
abstract：:The water soluble benzodiazepine midazolam was compared with diazepam, in doses of 0.07 mg kg-1 and 0.15 mg kg-1 respectively, administered i.v. to 100 patients undergoing gastroscopy. The degree of sedation, ease of endoscopy and recovery were comparable in the two groups. The effects of both drugs on arterial pressu...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/55.8.773
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:We defined the nature of the pharmacological interaction after intrathecal co-administration of ginsenosides with clonidine, and clarified the contribution of the α-2 adrenoceptors on the effect of ginsenosides. METHODS:Pain was evoked by injection of a formalin solution (5%, 50 μl) into the hindpaw of male...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeq367
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models. METHODS:Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice w...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael096
更新日期：2006-06-01 00:00:00
abstract：:Alcuronium 0.16 mg kg-1 was used to provide neuromuscular blockade in patients with chronic renal failure undergoing renal transplantation. Relaxation was found to be adequate for intubation and surgery. There were minimal alterations to cardiovascular variables. The dose required was small, and complete reversal occu...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.11.1229
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND:A significantly increased risk of acute kidney injury (AKI) with the prophylactic use of aprotinin has been reported in adults undergoing cardiac surgery, but not in children. Blood product transfusions have also been shown to carry an independent risk of AKI. The present study assessed associations between ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aes002
更新日期：2012-05-01 00:00:00
abstract：:A new design of tracheal tube cuff was compared with two types of high-volume, low-pressure (HVLP) cuffed tracheal tube for leakage of fluid from the subglottic space into the trachea. Spontaneous and positive-pressure ventilation were simulated using a mechanical lung, an intubated model trachea and a ventilator. Exc...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/80.6.796
更新日期：1998-06-01 00:00:00
abstract：:The effect of incubation at 37 degrees C, 46 degrees C, 47 degrees C and 48 degrees C for 1 h on the osmotic fragility of blood was determined. Blood taken from volunteers into ACD and CPD was examined after 1, 7, 14 and 21 days of storage. In addition, 22-day-old blood stored in CPD was examined. The osmotic fragilit...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.8.815
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. We assessed the effect of transcutaneous electric acupoint...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aeu001
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Miller laryngoscope blades are preferred for laryngoscopy in infants and children <2 yr of age. Despite their long history, the laryngeal view with the Miller blade size 1 has never been compared with that with the Macintosh (MAC) blade in children. This prospective, single-blinded, randomized study was desi...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aeu228
更新日期：2014-11-01 00:00:00
abstract：:A variant of a rebreathing/indicator-dilution technique was used to measure lung volume. Two or three indicators, which should have essentially the same pulmonary volume of distribution, were used. Gas compositions were measured by respiratory mass spectrometry and an extrapolation was used to allow for oxygen consump...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.3.289
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aev458
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:During preanaesthesia evaluation at an outpatient clinic, information is summarized and structured. We aimed to estimate the effectiveness of this process by determining the proportion of patients presenting for surgery who had valid preoperative anaesthesia assessment records, and also the proportion of pat...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeq200
更新日期：2010-11-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aev213
更新日期：2015-07-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验,收录出版
doi：10.1093/bja/72.6.688
更新日期：1994-06-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.2.184
更新日期：1985-02-01 00:00:00
abstract：:A total of 1442 patients who had major gynaecological surgery were recruited into three multicentre studies using a standard general anaesthetic technique in order to assess the efficacy of various doses of orally administered ondansetron in the prevention of postoperative nausea and vomiting. A total of 1257 patients...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,meta分析,多中心研究,随机对照试验
doi：10.1093/bja/71.4.517
更新日期：1993-10-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
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更新日期：1977-09-01 00:00:00
abstract：:We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.6.605
更新日期：1993-06-01 00:00:00
abstract：:A combination of exogenous surfactant and partial liquid ventilation (PLV) with perfluorocarbons should enhance gas exchange, improve respiratory mechanics and reduce tissue damage of the lung in acute lung injury (ALI). We used a small dose of exogenous surfactant with and without PLV in an experimental model of ALI ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.4.593
更新日期：2001-10-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh077
更新日期：2004-03-01 00:00:00
abstract：:We have assessed tracheal intubating conditions in 60 ASA I or II patients after induction of anaesthesia with propofol 2.5 mg kg-1 and alfentanil 10 or 20 micrograms kg-1 with or without i.v. lignocaine 1 mg kg-1. No neuromuscular blocking agents were administered. Patients were allocated randomly to four groups: gro...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-02-01 00:00:00
abstract：:We report a case of lumbar extradural abscess that presented 9 days after an elective Caesarean section performed under combined spinal-extradural anaesthesia. This was successfully treated conservatively with full recovery. The clinical course included development, and then resolution, of mild paraparesis. Conservati...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/78.5.591
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:The role of repeated prone positioning in intubated subjects with acute respiratory distress syndrome caused by COVID-19 remains unclear. METHODS:We conducted a retrospective observational cohort study of critically ill intubated patients with COVID-19 who were placed in the prone position between March 18,...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.09.042
更新日期：2021-01-01 00:00:00
abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
