Abstract：
:Atropine and glycopyrrolate were compared in a mixture with neostigmine for reversal of neuromuscular blockade in patients undergoing open heart surgery. In patients not receiving beta-blocking drugs, glycopyrrolate was shown to possess advantages over atropine in terms of a lower initial increase in heart rate, better protection against the muscarinic effects of neostigmine, and smaller increases in rate-pressure product. The concomitant administration of beta-adrenergic blocking therapy significantly attenuated the effect of reversal on heart rate and the differences between atropine and glycopyrrolate were not significant. There was no difference in the incidence of arrhythmias between patients who received beta-blocking drugs and those who did not.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Salem MG,Richardson JC,Meadows GA,Lamplugh G,Lai KMdoi
10.1093/bja/57.2.184subject
Has Abstractpub_date
1985-02-01 00:00:00pages
184-7issue
2eissn
0007-0912issn
1471-6771pii
S0007-0912(17)41489-9journal_volume
57pub_type
杂志文章abstract：:Purified serum cholinesterase 90 mg was administered to a patient with cholinesterase deficiency. The effect on the action of suxamethonium was studied. The half-life (44.7 h), time constant (64.5 h), rate constant (0.0155 h-1) and distribution volume (2740 ml) of the cholinesterase activity were determined. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.3.269
更新日期：1977-03-01 00:00:00
abstract：:The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in thre...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.4.345
更新日期：1978-04-01 00:00:00
abstract：BACKGROUND:Anaesthetic drugs act at sites within the brain that undergo profound changes during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in the EEG change with age. METHODS:We analysed the EEG in 155 patients aged 18-90 yr who received propofol (n=60) or sevoflurane (n=95) as the ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aev213
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The ProSeal laryngeal mask airway (PLMA) is a new laryngeal mask device with a modified cuff and a drainage tube. METHODS:We assessed the PLMA in 300 anaesthetized adults either paralysed or breathing spontaneously. We assessed insertion characteristics, airway seal pressures, haemodynamic response to inser...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/88.4.534
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:The influence of changes in body position relevant to neuraxial blockade on the location of the spinal cord and related neural structures has not been fully quantified. Our aim was to determine the changes, if any, that occur in the location of the spinal cord tip [equivalent to the tip of the conus medullar...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aen295
更新日期：2008-12-01 00:00:00
abstract：:We have compared the efficacy of adding varying concentrations of hyaluronidase to a standard mixture of 2% lidocaine and 1% ropivacaine to provide peribulbar anaesthesia for cataract surgery. We used (i) the time to adequate anaesthesia for surgery and (ii) ocular and eyelid movement scores at 8 min after block as cl...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/86.6.876
更新日期：2001-06-01 00:00:00
abstract：:To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.3.404
更新日期：1996-09-01 00:00:00
abstract：:Six male patients were studied on the morning following upper abdominal surgery for highly selective vagotomy. Nalbuphine hydrochloride was infused i.v. at different rates that increased progressively in each hour over a 4-h period. In the last 15 min of each hour, the plasma nalbuphine concentrations were almost stea...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.11.1356
更新日期：1987-11-01 00:00:00
abstract：BACKGROUND:Experimental studies and investigations in patients with cardiac diseases suggest that opioids at clinical concentrations have no important direct effect on myocardial relaxation and contractility. In vivo data on the effect of remifentanil on myocardial function in humans are scarce. This study aimed to inv...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeq414
更新日期：2011-04-01 00:00:00
abstract：:The neuromuscular and cardiovascular effects of atracurium were compared during nitrous oxide-isoflurane and nitrous oxide-fentanyl anaesthesia in healthy surgical patients. The dose-response curve was shifted significantly to the left during nitrous oxide-isoflurane anaesthesia (ED50 0.068 mg kg-1) as compared with n...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:In order to evaluate the use of the post-tetanic count (PTC) method during repetitive administration of vecuronium, we studied 20 patients allocated randomly to one of two groups: 10 patients received droperidol-fentanyl anaesthesia (control group); 10 other patients were given droperidol-fentanyl anaesthesia modified...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/65.4.487
更新日期：1990-10-01 00:00:00
abstract：:Since 1972, 367 patients with chronic low-back pain have been treated by electrical stimulation (e.s.). Patients with herniated disc lesions and spondylitis and allied conditions were included. Following e.s. 75-100% pain relief was obtained by 53% of the patients 50% pain relief by 27% and there was no improvement in...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.6.629
更新日期：1977-06-01 00:00:00
abstract：:We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/82.1.132
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:This study focuses on a recently developed robotic nerve block system and its impact on learning regional anaesthesia skills. We compared success rates, learning curves, performance times, and inter-subject performance variability of robot-assisted vs manual ultrasound (US)-guided nerve block needle guidance...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet440
更新日期：2014-06-01 00:00:00
abstract：:The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocurarine, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal patients was 56% for tu...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/54.5.513
更新日期：1982-05-01 00:00:00
abstract：:Sepsis is a constellation of clinical signs and symptoms resulting from excessive systemic host inflammatory response to infection. This inflammatory response is largely mediated by cytokines, which are released into the systemic circulation. Plasma concentrations of specific cytokines, TNF alpha, IL-1 beta, IL-6 and ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/77.1.110
更新日期：1996-07-01 00:00:00
abstract：:Atropine and glycopyrronium are frequently used for premedication to reduce oral and respiratory secretions and prevent bradycardia. Glycopyrronium is said to have similar antisialagogue effects, but is less likely to cause significant tachycardia than atropine. Different antimuscarinic receptor selectivity patterns c...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/74.5.549
更新日期：1995-05-01 00:00:00
abstract：:We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. D...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.4.456
更新日期：1993-04-01 00:00:00
abstract：:We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.6.605
更新日期：1993-06-01 00:00:00
abstract：:General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.5.455
更新日期：1981-05-01 00:00:00
abstract：:This report describes the anaesthetic management of a ventricular arrhythmia-prone patient with a prolonged Q-T interval for closed reduction and wiring of a mandibular fracture. The patient was premedicated with propranolol and anaesthetized with isoflurane (inhalation). Documentation of heart rate v. Q-T interval re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/55.4.361
更新日期：1983-04-01 00:00:00
abstract：:The use of atracurium in 25 patients undergoing general surgical procedures is described, neuromuscular function being monitored by the "train-of-four" stimuli. An initial dose of atracurium 0.5 mg kg-1 proved to be clinically acceptable, giving good conditions for endotracheal intubation and adequate muscle relaxatio...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/54.12.1243
更新日期：1982-12-01 00:00:00
abstract：:We have compared, in a randomized study in 26 patients, immediate and late postoperative recovery after elective laparoscopic cholecystectomy using the gasless, mechanical abdominal wall lift method with conventional carbon dioxide pneumoperitoneum. After the gasless method, tracheal extubation was performed significa...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/77.5.576
更新日期：1996-11-01 00:00:00
abstract：:Methodology for assessment of depth of anaesthesia based on analysis of the electroencephalogram (EEG) is controversial. Techniques range from display of single measures, for example median value of the frequency spectrum, to dedicated pattern recognition systems based on measures of several EEG features. We have comp...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.2.172
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Using a carrageenan inflammation rat model, we evaluated two experimental approaches to prolong sciatic nerve block on contralateral hyperalgesia. Method. We performed ipsilateral sciatic nerve block on the inflamed hind paw with bupivacaine-loaded microspheres suspended in dexamethasone (bupivacaine 12.5 mg...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh264
更新日期：2004-11-01 00:00:00
abstract：:Eighteen patients were studied, during operations under subarachnoid or extradural anaesthesia combined with general anaesthesia, to assess the influence of occlusion of inspiration on the duration of inspiration, and the likelihood of a relationship between lung volume and duration of inspiration. Ten patients breath...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.3.215
更新日期：1984-03-01 00:00:00
abstract：:We have studied the incidence of respiratory complications and hypoxic episodes during inhalation induction with isoflurane in 75 healthy unpremedicated children. Problems occurred less frequently when 4% isoflurane in oxygen was used from the outset than with traditional techniques using nitrous oxide and a gradually...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/66.3.327
更新日期：1991-03-01 00:00:00
abstract：:The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner. Sixty boys and girls between the ages of 4 and 10 yr who were to undergo surgery participated in the study. No analgesic premedication was given and the venous cannulatio...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.11.1242
更新日期：1986-11-01 00:00:00
abstract：:Robotic surgery pushes the frontiers of innovation in healthcare technology towards improved clinical outcomes. We discuss the evolution to five generations of robotic surgical platforms including stereotactic, endoscopic, bioinspired, microbots on the millimetre scale, and the future development of autonomous systems...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aex383
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS:PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1016/j.bja.2020.10.022
更新日期：2021-02-01 00:00:00
