Anaesthetic properties of dimethylthiourea.

Abstract:

:We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. Dimethylthiourea 0.5 g kg-1 decreased isoflurane MAC by 23%; at a dose of 2.0-4.0 g kg-1, it abolished the response to tail clamp. Doses of 4.0 g kg-1 were lethal in the presence of isoflurane. A serum concentration of dimethylthiourea approximately 1 mg ml-1 produced a 50% reduction in isoflurane MAC. These anaesthetic properties of dimethylthiourea may influence experimental studies that examine the biochemical and physiological properties of this agent.

journal_name

Br J Anaesth

authors

Koblin DD,Laster MJ,Liu J

doi

10.1093/bja/70.4.456

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

456-8

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46108-3

journal_volume

70

pub_type

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