A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man.

Abstract:

:The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in three phases with half-lives of less than 5, 30, 138 min, less than 5, 39, 141 and less than 5, 48, 144 min in the respective groups. Twenty-four hours after injection the renal excretion of the unchanged drug was 53% (15-100%) of the administered dose in group I, 67% (40-90%) in group II and 95% (89-100%) in group III. The biliary excretion of gallamine appeared to be negligible in man. The relationship between renal excretion and duration of action of gallamine, and the influence of some intraoperative factors on drug disposition, are discussed.

journal_name

Br J Anaesth

authors

Agoston S,Vermeer GA,Kersten UW,Scaf AH

doi

10.1093/bja/50.4.345

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

345-51

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45188-9

journal_volume

50

pub_type

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