Abstract:
:Six male patients were studied on the morning following upper abdominal surgery for highly selective vagotomy. Nalbuphine hydrochloride was infused i.v. at different rates that increased progressively in each hour over a 4-h period. In the last 15 min of each hour, the plasma nalbuphine concentrations were almost steady (73-68, 71-82, 116-113 and 201-208 ng ml-1). Patients and an observer made hourly assessments of pain and sedation. Although the changes in the pain and sedation scores were not significant, the patients' mean pain scores increased when the mean plasma nalbuphine concentrations were greater (greater than 82 ng ml-1), which suggested that nalbuphine analgesia had been reversed. Nalbuphine caused sedation and possibly induced amnesia which could invalidate retrospective assessment, since the patients' assessment of analgesic efficacy at the end of the study was good. No cardiovascular depression or significant decrease in the ventilatory rate was recorded.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Pugh GC,Drummond GBdoi
10.1093/bja/59.11.1356subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1356-63issue
11eissn
0007-0912issn
1471-6771pii
S0007-0912(17)43234-Xjournal_volume
59pub_type
杂志文章abstract::We have evaluated the clinical utility and blood propofol concentrations produced with two different infusion regimens for propofol, given to supplement 67% nitrous oxide-morphine anaesthesia. Patients received a standardized three-step infusion of propofol based either on body weight (weight-corrected group) or on a ...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/74.4.362
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Dexmedetomidine is an α-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques. We therefore designed this prospective, double-blinded, controlled volunteer study to investigate the effects of dexmedetomidine as an adjuvant to ropivacaine on pe...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1093/bja/aes400
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Capnography may provide useful non-invasive bedside information concerning heterogeneity in lung ventilation, ventilation-perfusion mismatching and metabolic status. Although the capnogram may be recorded by mainstream and sidestream techniques, the capnogram indices furnished by these approaches have not pr...
journal_title:British journal of anaesthesia
pub_type: 评论,杂志文章
doi:10.1093/bja/aew127
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Infraclavicular axillary vein cannulation is not commonly used for central venous access because identifying the surface landmarks is difficult. Ultrasound guided axillary vein puncture has not been well described. We assessed ultrasound imaging to guide catheterization of the infraclavicular axillary vein. ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeh187
更新日期:2004-08-01 00:00:00
abstract:Background.:Compromised tissue oxygenation is one of the root causes of dysfunction of various organs and postoperative complications. Oxygenation of different tissue beds may follow different patterns of change during physiological derangement. Methods.:Patients undergoing elective major posterior spine surgery parti...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aex008
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The debate on lung-protective ventilation strategies for surgical patients is ongoing. Evidence suggests that the use of low tidal volume VT improves clinical outcomes. However, the optimal levels of PEEP and recruitment manoeuvre (RM) strategies incorporated into low VT ventilation remain unclear. METHODS:...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,meta分析
doi:10.1016/j.bja.2019.10.024
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Assessments of labour pain focus on pain intensity, not on duration. We aimed to assess the importance labouring women apply to pain intensity and duration before labour and post-delivery. METHODS:Forty healthy women scheduled for labour induction were enrolled in this institutional review board-approved, p...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeu149
更新日期:2014-09-01 00:00:00
abstract::We report two patients who developed skin necrosis following an intramuscular injection of non-steroidal anti-inflammatory drug into the anteriolateral area of their thigh. Both patients required further multiple operations and one developed life threatening septicaemia. They were left with disfiguring scars. Skin nec...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/88.1.139
更新日期:2002-01-01 00:00:00
abstract::Twenty consecutive patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were allocated at random to group 1 (n = 10, high inspired oxygen fraction (FIO2) after CPB), or group 2 (n = 10, moderate FIO2 after CPB). The effects of each FIO2 on arterial and mixed venous concentrations of endothelin-1 (ET-1...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/84.5.565
更新日期:2000-05-01 00:00:00
abstract::For 6 months after renal transplant serum cholinesterase concentrations were measured in 10 patients. The value decreased in the first 15 days after operation, but was normal thereafter. Liver function tests were normal throughout the study; the cholinesterase changes were independent of immunosuppressive therapy. ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/51.9.881
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:Pulse pressure variation (PPV) and stroke volume variation (SVV) are robust indicators of fluid responsiveness in mechanically ventilated supine patients. The aim of the study was to evaluate the ability of PPV and SVV to predict fluid responsiveness in mechanically ventilated patients in the prone position ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeq031
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:An important cause of coagulopathy in cardiac surgery is impaired thrombin generation. While plasma is often used to correct this element of the coagulopathy, studies in vitro suggest that prothrombin complex concentrates (PCCs) might be more effective. Comparative data, however, are scant. METHODS:We compa...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1016/j.bja.2018.02.017
更新日期:2018-05-01 00:00:00
abstract::We investigated the effect of incision and sternotomy on the auditory evoked potential (AEP) and EEG, to try to predict a haemodynamic response to incision or sternotomy using the AEP and EEG in 41 patients undergoing cardiac surgery during propofol and alfentanil anaesthesia. The AEP and EEG were recorded before inci...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/76.5.685
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bja.2019.06.026
更新日期:2019-12-01 00:00:00
abstract::Intragastric pressure was measured in 20 patients before, and immediately after, the induction of anaesthesia with thiopentone. Intragastric pressure decreased in patients whose weights were the same as or less than expected, and increased in five of seven patients whose weights were greater than expected (P = 0.0013)...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/56.8.873
更新日期:1984-08-01 00:00:00
abstract:INTRODUCTION:Patients with hip fractures are usually frail and elderly with a 30-day mortality in excess of 10% in European series. Perioperative morbidity is often multifactorial in nature, and unimodal interventions will not necessarily decrease mortality. The purpose of this prospective study was to analyse causes o...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aei010
更新日期:2005-01-01 00:00:00
abstract::In the postoperative period fifty-six healthy patients undergoing cholecystectomy or operations for duodenal ulcer, received, in a randomized order, i.m., "high-level" or "low-level" extradural morphine. Thirty-five per cent in the i.m. group, 33% in the high-level group and 50% in the low-level group suffered urinary...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/54.11.1175
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Thermal, mechanical, and electrical stimuli are often used in acute pain studies and cause qualitatively different pain sensations. Yet, the comparative electroencephalogram (EEG) changes caused by these stimuli have not been studied. We hypothesized that because these stimuli cause different pain sensations...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/ael377
更新日期:2007-03-01 00:00:00
abstract::Two patients are described in whom failure of the Pollard endotracheal tube produced complete respiratory obstruction. Comparisons are made of external diameters, resistance to gas flow and resistance to compression between Pollard tubes and several conventional tubes. It is concluded that the Pollard tube is not sati...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/49.2.179
更新日期:1977-02-01 00:00:00
abstract::Percutaneous dilatational tracheostomy (PDT) is associated with a number of life-threatening complications. We present a case of massive and fatal arterial haemorrhage that occurred in the intensive care unit during an elective PDT on an 86-year-old woman following earlier evacuation of a traumatic subdural haematoma....
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeg074
更新日期:2003-04-01 00:00:00
abstract::This was a prospective, non-randomized, multicentre study of rocuronium (Org 9426) in 40 elective Caesarean section patients at full term without fetal distress. Anaesthesia was induced with thiopentone 4-6 mg kg-1 i.v. and rocuronium 0.6 mg kg-1 and maintained with isoflurane and nitrous oxide in oxygen. Monitors inc...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/bja/73.3.336
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:In a series of ex vivo and in vivo studies we investigated the ability of repetitive ketamine administration to alter the metabolism and anaesthetic effect of propofol and the role of ketamine-mediated P-450 2B induction in rats. METHODS:Male Wistar rats were pretreated with 80 mg kg(-1) ketamine i.p. twice...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/ael173
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS:PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1016/j.bja.2020.10.022
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:LMA CTrach (CT), a modified version of the intubating LMA Fastrach, allows continuous video-endoscopy of the tracheal intubation procedure. We tested the hypothesis that the CT is efficient for tracheal intubation of morbidly obese patients who are at risk of a difficult airway. METHODS:After Ethics' Commit...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1093/bja/ael219
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:To determine the pharmacokinetics (PK) of a new i.v. formulation of paracetamol (Perfalgan) in children ≤15 yr of age. METHODS:After obtaining written informed consent, children under 16 yr of age were recruited to this study. Blood samples were obtained at 0, 15, 30 min, 1, 2, 4, 6, and 8 h after administr...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aes025
更新日期:2012-05-01 00:00:00
abstract::The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubocurarine). Sedation for patients breathing spontaneously with positive airway pressure was conti...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/58.10.1104
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Descriptions of the pharmacokinetics and metabolism of morphine and its metabolites in young children are scant. Previous studies have not differentiated the effects of size from those related to age during infancy. METHODS:Postoperative children 0-3 yr old were given an intravenous loading dose of morphine...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/aeh042
更新日期:2004-02-01 00:00:00
abstract::The action of halothane on the pulmonary vasoconstrictor response to unilateral alveolar hypoxia was studied in two groups of dogs. In the first group the redistribution of blood flow between the two lungs was studied with a radioactive isotope method, which provided intermittent measurements, whilst in the second gro...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/50.12.1185
更新日期:1978-12-01 00:00:00
abstract::We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/82.1.132
更新日期:1999-01-01 00:00:00
abstract::The Swedish Society of Anaesthetists conducted a nationwide retrospective survey of clinical experience with extradural and intrathecal opiates. Special interest was focused on the frequency and type of ventilatory depression. The questionnaire was answered by 84 of 93 departments (90%). Up to May 1981 extradural morp...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/54.5.479
更新日期:1982-05-01 00:00:00