当前位置： SCI文献检索 > BRITISH JOURNAL OF ANAESTHESIA期刊下所有文献 > Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.

Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.

Abstract：

BACKGROUND:Using a carrageenan inflammation rat model, we evaluated two experimental approaches to prolong sciatic nerve block on contralateral hyperalgesia. Method. We performed ipsilateral sciatic nerve block on the inflamed hind paw with bupivacaine-loaded microspheres suspended in dexamethasone (bupivacaine 12.5 mg) and with amitriptyline (6.25 and 12.5 mg) as ultralong-acting local anaesthetics. Bupivacaine (1.25 mg) was used as long-acting local anaesthetic and saline was used as a control. The sixth group received amitriptyline 6.25 mg intraperitoneally (n=10 for each group). RESULTS:The duration of ipsilateral nerve block was 2 h for bupivacaine, 7 h for amitriptyline 6.25 mg, 11 h for amitriptyline 12.5 mg and 21 h for bupivacaine-loaded microspheres in suspension with dexamethasone. Whereas contralateral hyperalgesia was not observed during block produced by bupivacaine-loaded microspheres, contralateral hyperalgesia was observed with sciatic nerve block using amitriptyline. CONCLUSIONS:Because of the differential effect observed on the contralateral side, the mechanism underlying the prolongation of ipsilateral block with amitriptyline may not result only from a prolonged Na(+) channel blockade but might be explained by a local toxic effect or lack of systemic actions.

journal_name

Br J Anaesth

journal_title

British journal of anaesthesia

authors

Estebe JP,Gentili ME,Le Corre P,Leduc C,Moulinoux JP,Ecoffey C

doi

10.1093/bja/aeh264

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

705-9

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)35825-7

journal_volume

93

pub_type

杂志文章

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