Opioid inhibition of rapid eye movement sleep by a specific mu receptor agonist.

Abstract:

:Patients receiving opioids report feeling sleepy, but opioids actually inhibit the rapid eye movement phase of sleep (REM). Inhibition of REM sleep is followed by a rebound increase in REM sleep associated with cardiopulmonary complications. The medial pontine reticular formation (mPRF) is a brain region from which morphine can inhibit REM sleep. The present study tested the hypothesis that specific subtypes of opioid receptors within the mPRF mediate inhibition of REM sleep. Synthetic opioid agonists selective for mu, delta and kappa subtypes were microinjected into the mPRF of four awake cats and polygraphic recordings of sleep and breathing were obtained. An enkephalinase inhibitor was microinjected into the mPRF to assess the contribution of endogenous opioids to the control of sleep and breathing. Only the mu agonist significantly inhibited REM sleep, and no opioid depressed breathing. These results demonstrate that opioid-induced REM sleep inhibition is mediated by mu receptor subtypes in the mPRF.

journal_name

Br J Anaesth

authors

Cronin A,Keifer JC,Baghdoyan HA,Lydic R

doi

10.1093/bja/74.2.188

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

188-92

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)40755-0

journal_volume

74

pub_type

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