Abstract:
:To understand the sequential response of the autonomic nervous system to pregnancy, we studied heart rate variability in 23 first trimester, 23 second trimester and 21 third trimester pregnant women. Twenty non-pregnant women were recruited as controls. Time and frequency domain measures of heart rate variability in three recumbent positions were compared. We found that normalized high-frequency power in the supine position increased significantly in the first trimester (42.2 (95% confidence interval (CI) 5.4) nu (normalized unit); P < 0.05) compared with non-pregnant controls (33.0 (6.0) nu), and then decreased progressively in the second (27.3 (6.7) nu) and third (21.8 (6.0) nu; P < 0.05) trimesters. The low-/high-frequency power ratio in the supine position decreased significantly in the first trimester (0.8 (0.3); P < 0.05) compared with that of non-pregnant controls (1.1 (0.3)) and increased progressively in the second (1.5 (0.4)) and third (2.1 (0.8); P < 0.05) trimesters. When the position was changed from the supine to the right lateral decubitus, the percentage change in normalized high-frequency power correlated significantly and negatively with normalized high-frequency power in the supine position in non-pregnant controls (r = -0.56, P = 0.01) and in pregnant women in the first (r = -0.44, P = 0.034), second (r = -0.68, P < 0.001) and third (r = -0.68, P < 0.001) trimesters. These results indicate that autonomic nervous activity shifted towards a lower sympathetic and higher vagal modulation in the first trimester, and changed towards a higher sympathetic and lower vagal modulation in the third trimester as gestational age increased. The balance between the haemodynamic changes of pregnancy and aortocaval compression caused by the enlarging gravid uterus may be responsible for the biphasic changes in autonomic nervous activity during pregnancy.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Kuo CD,Chen GY,Yang MJ,Lo HM,Tsai YSdoi
10.1093/oxfordjournals.bja.a013433subject
Has Abstractpub_date
2000-03-01 00:00:00pages
323-9issue
3eissn
0007-0912issn
1471-6771pii
S0007-0912(17)38828-1journal_volume
84pub_type
杂志文章abstract::In inflammation, leucocytes containing opioid peptides migrate into the tissue. Opioid peptides can be released and bind to opioid receptors on peripheral nerve terminals, which counteracts inflammatory pain. Migration of opioid peptide-containing leucocytes is controlled by chemokines and adhesion molecules. Neurokin...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...
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abstract:BACKGROUND:General anaesthesia is a balance between hypnosis and analgesia. We investigated whether an increase in remifentanil blood concentration would reduce the amount of propofol required to maintain a comparable level of anaesthesia in 60 patients undergoing ambulatory surgery. METHODS:Patients were allocated ra...
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pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Normalization of plasma fibrinogen levels may be associated with satisfactory haemostasis and reduced bleeding. The aim of this retrospective study was to assess fibrinogen recovery parameters after administration of fibrinogen concentrate (Haemocomplettan P) to patients with diffuse bleeding in cardiovascul...
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-03-01 00:00:00
abstract::Cumulation and interaction of neuromuscular blocking effects of neomycin and tubocurarine were determined on responses of the tibialis anterior muscle of the anaesthetized cat to indirect stimulation. Neuromuscular block produced by neomycin was cumulative despite rapid and apparent full recovery of twitch tension and...
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更新日期:1981-06-01 00:00:00
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journal_title:British journal of anaesthesia
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更新日期:1998-11-01 00:00:00
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更新日期:1989-05-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
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更新日期:1989-05-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
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更新日期:1986-05-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-04-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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更新日期:1995-07-01 00:00:00