Comparison of the effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure in anaesthetized man.

Abstract:

:The effects of Org NC 45 and pancuronium bromide on heart rate and arterial pressure were studied in anaesthetized man. A bolus of either Org NC 45 0.1 mg kg-1 or pancuronium 0.1 mg kg-1 was administered to lightly anaesthetized unstimulated subjects. Following Org NC 45 heart rate decreased in the majority of subjects (mean and SEM 3.78 +/- 1.36), whereas after pancuronium heart rate was increased (mean and SEM 11.91 +/- 1.9). The changes in mean arterial pressure observed were minimal. The effect of endotracheal intubation on mean arterial pressure was then studied. Increase of mean arterial pressure was observed in all subjects. The increase was more marked in those patients who had received pancuronium and was significantly higher than in those patients who had received Org NC 45 (P less than 0.01). We conclude that Org NC 45 is devoid of vagal blocking action, and that the difference in response to the stimulus of endotracheal intubation is a result of the different effects exerted on the sympathetic nervous system by Org NC 45 and pancuronium.

journal_name

Br J Anaesth

authors

Barnes PK,Smith GB,White WD,Tennant R

doi

10.1093/bja/54.4.435

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

435-9

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)42772-3

journal_volume

54

pub_type

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