Abstract：
BACKGROUND:The objective of the present study was to investigate the effects of increasing doses of norepinephrine (NE) with or without arginine-vasopressin (AVP) on intestinal oxygen supply and jejunal mucosal tissue oxygen tension in an acute endotoxic pig model. METHODS:In this prospective, randomized, experimental study on 24 domestic pigs, jejunal mucosal tissue PO2 (PO2muc) was measured using two Clark-type surface oxygen electrodes. Oxygen saturation of jejunal microvascular haemoglobin (HbO2j) was determined by tissue reflectance spectrophotometry. Systemic haemodynamic variables, mesenteric-venous and systemic acid-base and blood gas variables, and lactate measurements were recorded. Measurements were performed at baseline, after Escherichia coli lipopolysaccharide (LPS) administration, and at 20 min intervals during incremental NE infusion (0.05, 0.1, 0.5, 1.0, and 2 microg kg(-1) min(-1), respectively) with 57 mU kg(-1) h(-1) AVP (n=8; NE+AVP group) or without (n=8; NE group); or infusion of an equal amount of normal saline (n=8; CON group). RESULTS:LPS infusion led to a significant (P<0.05) decrease of PO2muc and HbO2j. Both NE and NE+AVP increased arterial pressure, cardiac output, and mesenteric artery blood flow. Concomitant to an increase in systemic oxygen delivery, NE improved PO2muc and HbO2j. NE alone was superior in restoration of PO2muc when compared with NE+AVP. CONCLUSIONS:Both NE and NE+AVP improved global haemodynamics and systemic oxygen transport variables when compared with control animals in an acute endotoxic pig model. NE improved jejunal PO2muc at all dosages. NE effects were significantly blunted by simultaneous administration of AVP.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Maier S,Hasibeder W,Pajk W,Hengl C,Ulmer H,Hausdorfer H,Wurzinger B,Knotzer Hdoi
10.1093/bja/aep239subject
Has Abstractpub_date
2009-11-01 00:00:00pages
691-700issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)33908-9journal_volume
103pub_type
杂志文章abstract：:The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/79.1.122
更新日期：1997-07-01 00:00:00
abstract：:We describe an obstetric patient who developed incapacitating headache after inadvertent dural tap and was treated with repeated blood patching. She subsequently developed severe lumbar back pain which, after exclusion of suspected extradural abscess, was treated successfully with simple analgesics and physiotherapy. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/78.3.334
更新日期：1997-03-01 00:00:00
abstract：:We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. Dexmedetomidine decreased both noradrenaline release and cell firing rate in a concentration-dependent fashion, with an EC5...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.3.447
更新日期：1993-09-01 00:00:00
abstract：:The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner. Sixty boys and girls between the ages of 4 and 10 yr who were to undergo surgery participated in the study. No analgesic premedication was given and the venous cannulatio...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.11.1242
更新日期：1986-11-01 00:00:00
abstract：BACKGROUND:Increasing fresh gas flow (FGF) to a circle breathing system reduces carbon dioxide (CO2) absorbent consumption. We assessed the environmental and economic impacts of this trade-off between gas flow and absorbent consumption when no inhalational anaesthetic agent is used. METHODS:A test lung with fixed CO2 ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.07.043
更新日期：2020-11-01 00:00:00
abstract：:We present a case of pulmonary thromboendarterectomy performed successfully in a patient with stomatocytosis. Stomatocytosis is a rare condition of abnormal erythrocyte morphology in which haemolysis and hyperkalaemia occur at cooler temperatures. A 35-yr-old male with stomatocytosis was referred for pulmonary thrombo...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg237
更新日期：2003-11-01 00:00:00
abstract：:Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza™) was recently approved in the EU a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aer260
更新日期：2011-10-01 00:00:00
abstract：:Using human nasal cytological brushings, we have investigated the effects of morphine on ciliary function by measurement of cilia beat frequency in vitro, and we have also determined opioid receptor binding in these specimens. We obtained ciliated samples from seven volunteers, and measured cilia beat frequency using ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.2.274
更新日期：1996-02-01 00:00:00
abstract：:We studied the elimination rate of nitrous oxide in 36 patients undergoing orthopaedic surgery. They were allocated randomly to one of six groups which differed in time of nitrous oxide exposure and mode of ventilation. In order to simulate recovery conditions, nitrous oxide administration was discontinued after 30, 6...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/71.2.189
更新日期：1993-08-01 00:00:00
abstract：:The oxygen delivery (DO2) and consumption (VO2) relationship in brain-dead organ donors is unknown. Therefore, in a prospective study, we determined the DO2/VO2 relationship in 21 consecutive brain-dead patients. Patients were allocated to one of two groups, according to plasma lactate concentration: normal (group NL,...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.6.783
更新日期：1996-06-01 00:00:00
abstract：:We present a case where rocuronium 80 mg (3 x ED95) was used in a rapid sequence induction in a 80-kg pregnant patient with an open eye injury. The patient was also receiving magnesium 2 g h-1 i.v. for preterm labour. The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be appr...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.5.669
更新日期：1996-11-01 00:00:00
abstract：:Plain bupivacaine 0.5% or 0.75% was injected intrathecally in four groups of 10 patients. Group A received 0.75% bupivacaine 2.7 ml at L3/4, group B 0.5% bupivacaine 4 ml at L3/4, group C 0.75% bupivacaine 2.7 ml at L2/3 and group D 0.75% bupivacaine 2 ml at L3/4. A very wide range of height of block was found in each...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.3.292
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND:Target-controlled infusion (TCI) systems use pharmacokinetic (PK) models to predict the drug infusion rates necessary to achieve a desired target plasma or effect-site concentration. As new PK models are developed and implemented in TCI systems, there can be uncertainty as to which target concentrations are ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.05.051
更新日期：2020-10-01 00:00:00
abstract：:The arterial to end-tidal PCO2 difference (PaCO2-PE'CO2) was measured in five anaesthetized dogs during controlled ventilation at 0.25 Hz (15 b.p.m.) and during high frequency jet ventilation at 1, 3 and 5 Hz. Because of the slow response of the infra-red carbon dioxide analyser, satisfactory recordings of end-tidal c...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.2.240
更新日期：1987-02-01 00:00:00
abstract：:Haemodynamic changes (supraventricular tachycardia, decreases in arterial pressure) were observed during laryngoscopy and intubation of the trachea in a patient receiving nifedipine and verapamil. Before the induced stresses of laryngoscopy and tracheal intubation, these drugs had controlled the patient's arterial pre...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/58.3.357
更新日期：1986-03-01 00:00:00
abstract：:Critical narrowing of the dependent airways was examined in anaesthetized dogs with closed chests. Two techniques were used, (a) "closing" volume (CV), measured from the expired nitrogen plateau and (b) tantalum bronchography, to measure the calibre of airways of 3-8 mm diameter in the upper (UZ), middle (MZ) and lowe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.8.735
更新日期：1978-08-01 00:00:00
abstract：:Closed-loop control of neuromuscular blockade, using a semi-continuous infusion of vecuronium, is described. In 28 patients, the average neuromuscular transmission was between 13 and 17% of control. Requirements for vecuronium averaged 1.1 micrograms kg-1 min-1 (0.8-1.5 micrograms kg-1 min-1), being in the same range ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/58.10.1100
更新日期：1986-10-01 00:00:00
abstract：:Blood flow to functionally different vascular beds was examined during a sodium nitroprusside infusion in 10 dogs anaesthetized with halothane (1 MAC) in oxygen. Blood flows were measured in the ascending aorta, and the coeliac, superior mesenteric, renal and iliac arteries. In two dogs, regional vascular impedance an...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.8.735
更新日期：1977-08-01 00:00:00
abstract：Background:In addition to general anaesthetic effects, sevoflurane can also induce hyperactive behaviours during induction and recovery, which may contribute to neurotoxicity; however, the mechanism of such effects is unclear. Volatile anaesthetics including isoflurane have been found to activate the kainate (GluK2) re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aex043
更新日期：2017-11-01 00:00:00
abstract：:A series of 443 spinal anaesthetics is described. The procedures included operative vaginal delivery, removal of retained placenta and a miscellaneous group common to most obstetric units. Failure to provide effective relief of pain occurred in 5.2% of patients. There was one potentially serious complication, but with...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/51.6.531
更新日期：1979-06-01 00:00:00
abstract：:Two techniques for endotracheal anaesthesia in dental outpatients have been compared: a spontaneous ventilation technique using nitrous oxide, oxygen and halothane, and a controlled ventilation technique using nitrous oxide and oxygen, with tubocurarine and fentanyl. The latter technique has several advantages: abolit...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/48.9.919
更新日期：1976-09-01 00:00:00
abstract：:We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. D...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.4.456
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:This study compared the efficacy of topical anaesthesia with levobupivacaine 0.75% vs lidocaine 2% during cataract surgery by phacoemulsification. METHODS:A prospective, randomized, double-blind study comparing two agents for topical anaesthesia in cataract surgery. Two hundred and forty-six consecutive pat...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aen369
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:The aim of this study is to test the hypothesis that a standard 30-min break in a routine 7.5 h period of work makes a difference in cognitive function. METHODS:In a double-blinded, cross-over trial 30 residents in anaesthesia were randomized to receive or not to receive a 30-min break between the assessmen...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/ael151
更新日期：2006-09-01 00:00:00
abstract：:Abnormal oxygen use and organ failure in the critically ill may result from 'poisoning' of mitochondrial function. Measurement of arterial ketone body ratio (AKBR) has been proposed to reflect mitochondrial redox state and may provide a useful marker to monitor mitochondrial function in the critically ill. We measured...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/83.2.325
更新日期：1999-08-01 00:00:00
abstract：:We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent manner with an ED50 value of 140 (95% confidence limits 123-160) mg kg-1 (n = 40; eight animals per d...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/83.4.665
更新日期：1999-10-01 00:00:00
abstract：:We describe an anaesthesia simulator capable of simulating all possible situations during anaesthesia. The Leiden anaesthesia simulator (LAS) may be used with most commercially available anaesthesia equipment and monitors, which are connected to the simulated patient as they are to a patient. A commercially available ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/73.3.287
更新日期：1994-09-01 00:00:00
abstract：:We have studied the effects of alcuronium in 10 healthy, non-anaesthetized volunteers after they had been taking oral pyridostigmine 30 mg 8 hourly. The responses of adductor pollicis were recorded using an isolated forearm procedure (IFP) during onset and recovery of neuromuscular block produced by 1.5 mg of relaxant...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/66.3.365
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:A pulmonary hypertensive crisis (PHC) can be a life-threatening condition. We established a PHC model by exposing rats with monocrotaline (MCT)-induced pulmonary hypertension to acute hypoxia, and investigated the effects of vasopressin, phenylephrine, and norepinephrine on the PHC. METHODS:Four weeks after...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2019.01.014
更新日期：2019-04-01 00:00:00
abstract：:Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.11.1091
更新日期：1976-11-01 00:00:00
