Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model.

abstract：:Ketamine, as the sole anaesthetic agent, was assessed in a double-blind study of 135 female patients who underwent laparoscopic sterilization. The patients were allocated randomly to one of four groups according to the type (pentobarbitone or droperidol) and route (i.v. or i.m.) of premedication. In addition all the p...

journal_title：British journal of anaesthesia

authors： Figallo EM,Casali H,McKenzie R,Tantisira B,Wadhwa RK,Taylor FH

更新日期：1977-11-01 00:00:00

abstract：:The problems of selection of tracheal tubes, and the need for a rationale, are outlined. Tracheal tubes of 7.5 mm and 8.5 mm i.d. are recommended for female and male patients, respectively. Tracheal size was determined using high pressure-low volume cuffs as measuring devices. The average diameter of the cuff at seal ...

journal_title：British journal of anaesthesia

authors： Chandler M,Crawley BE

更新日期：1986-01-01 00:00:00

abstract：:In 10 dogs, one carotid sinus was isolated from the systemic circulation without disturbing its sympathetic innervation. The isolated sinus was connected to a servo-controlled pressure generator which kept mean intrasinus pressure, pulse pressure, and frequency of pulsation constant. The carotid sinus baroreceptor ner...

journal_title：British journal of anaesthesia

authors： Behnia R,Koushanpour E,Shanks CA,McCarthy WJ

更新日期：1987-04-01 00:00:00

abstract：:The determination of blood flow, i.e. cardiac output, is an integral part of haemodynamic monitoring. This is a review on noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. We present the underlying principles and validation data of the following technologies: thoracic elect...

journal_title：British journal of anaesthesia

authors： Saugel B,Cecconi M,Wagner JY,Reuter DA

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Opioid prescribing is increasing worldwide with associated increases in misuse and other harms. We studied variations in national opioid prescription rates, indicators of prescribing quality, co-prescribing of benzodiazepines and relationship with pain severity in Scotland. METHODS:Electronic linkages of op...

journal_title：British journal of anaesthesia

authors： Torrance N,Mansoor R,Wang H,Gilbert S,Macfarlane GJ,Serpell M,Baldacchino A,Hales TG,Donnan P,Wyper G,Smith BH,Colvin L

更新日期：2018-06-01 00:00:00

abstract：:Cardiovascular risk prediction using clinical risk factors is integral to both the European and the American algorithms for preoperative cardiac risk assessment and perioperative management for non-cardiac surgery. We have reviewed these risk factors and their ability to guide clinical decision making. We examine thei...

journal_title：British journal of anaesthesia

authors： Biccard BM,Rodseth RN

更新日期：2011-08-01 00:00:00

abstract：:As constant hypoxaemia itself may trigger development of apnoea and periodic breathing, we have studied the effect of oxygen therapy on the occurrence of late postoperative episodic hypoxaemia. Thirty-five patients without cardiopulmonary disease and undergoing elective total hip replacement were monitored with a puls...

journal_title：British journal of anaesthesia

authors： Rosenberg J,Pedersen MH,Gebuhr P,Kehlet H

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:One major risk factor of the sitting position for neurosurgery is air embolism, especially in patients with persistent foramen ovale (PFO). The first aim of this prospective study was to evaluate a bedside method for detecting PFO using transcranial Doppler sonography (TCD) with contrast medium. A second aim...

journal_title：British journal of anaesthesia

authors： Engelhardt M,Folkers W,Brenke C,Scholz M,Harders A,Fidorra H,Schmieder K

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the prevalence of postoperative nausea and vomiting (PONV) after fast-track cardiac anaesthesia, risk factors for PONV and its influence on the length of stay in the intensive care unit (ICU). METHODS:A prospective study was performed in the cardiothoracic ICU (CTICU) ...

journal_title：British journal of anaesthesia

authors： Kogan A,Eidelman LA,Raanani E,Orlov B,Shenkin O,Vidne BA

更新日期：2003-08-01 00:00:00

abstract：:In a prospective double-blind study, single dose lumbar extradural blockade was instituted in 80 healthy male patients undergoing lower abdominal surgery. Patients were assigned randomly to one of four groups. Each group received treatment with 0.5% bupivacaine 20 ml containing adrenaline 1:200 000. To this solution w...

journal_title：British journal of anaesthesia

authors： Rucci FS,Cardamone M,Migliori P

更新日期：1985-03-01 00:00:00

abstract：:A modification of an i.v. regional anaesthesia (IVRA) technique is described in which the arm is re-exsanguinated before surgery (re-IVRA). IVRA and re-IVRA were compared for quality of operative field, sensory and motor block, quality of analgesia and blood concentrations of prilocaine, lignocaine and mepivacaine in ...

journal_title：British journal of anaesthesia

authors： Rawal N,Hallén J,Amilon A,Hellstrand P

更新日期：1993-03-01 00:00:00

abstract：:Simple methods are described for computing the variables derived from the Siggaard-Andersen nomogram, where the in vitro buffer line is either established by direct measurement or calculated from measurements of pH, Pco2 and haemoglobin. Calculations are performed using the equation of the pH-log Pco2 buffer line, the...

journal_title：British journal of anaesthesia

authors： Blackburn JP,Preston TD,Strickland DA

更新日期：1975-04-01 00:00:00

abstract：:This report describes the anaesthetic management of a ventricular arrhythmia-prone patient with a prolonged Q-T interval for closed reduction and wiring of a mandibular fracture. The patient was premedicated with propranolol and anaesthetized with isoflurane (inhalation). Documentation of heart rate v. Q-T interval re...

journal_title：British journal of anaesthesia

authors： Medak R,Benumof JL

更新日期：1983-04-01 00:00:00

abstract：:We report the case of a morbidly obese patient who developed rhabdomyolysis with acute renal failure, hepatic dysfunction, and an increase of cardiac troponin-1 after total knee arthroplasty. Postoperative rhabdomyolysis has a wide range of triggers and differential diagnoses that should be considered by the anaesthes...

journal_title：British journal of anaesthesia

authors： Karcher C,Dieterich HJ,Schroeder TH

更新日期：2006-12-01 00:00:00

abstract：:The concentrations of volatile hydrocarbons were studied in breath samples from patients before and after anaesthesia. In patients to whom halothane was administered, there was a significant increase in the concentration of isobutene (from 0.43 +/- 0.09 to 4.66 +/- 2.22 nmol litre-1). There was no change in the concen...

journal_title：British journal of anaesthesia

authors： Hempel V,May R,Frank H,Remmer H,Köster U

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:A recent study showed that the noble gas helium induces early myocardial preconditioning. Cyclooxygenase-2 (COX-2) has been shown to be an important mediator in the signal transduction of late preconditioning. In the present study, we investigated whether helium induces late preconditioning in a concentratio...

journal_title：British journal of anaesthesia

authors： Huhn R,Heinen A,Weber NC,Hieber S,Hollmann MW,Schlack W,Preckel B

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Pressures (Pe) exerted by bronchial blockers on the inner wall of the bronchi may cause mucosal ischaemia. Our aims were as follows: (i) to compare the intracuff pressure (Pi) and Pe exerted by commercially available bronchial blockers in an in vitro and an ex vivo model; (ii) to investigate the influence of...

journal_title：British journal of anaesthesia

authors： Carassiti M,Mattei A,Pizzo CM,Vallone N,Saccomandi P,Schena E

更新日期：2016-09-01 00:00:00

abstract：:The Swedish Society of Anaesthetists conducted a nationwide retrospective survey of clinical experience with extradural and intrathecal opiates. Special interest was focused on the frequency and type of ventilatory depression. The questionnaire was answered by 84 of 93 departments (90%). Up to May 1981 extradural morp...

journal_title：British journal of anaesthesia

authors： Gustafsson LL,Schildt B,Jacobsen K

更新日期：1982-05-01 00:00:00

abstract：:Transoesophageal echocardiography (TOE) is valuable for perioperative monitoring in patients at risk from haemodynamic disturbance. However, its use is not practicable in patients undergoing surgical procedures under regional anaesthesia. We describe two cases showing that transthoracic echocardiography (TTE) has the ...

journal_title：British journal of anaesthesia

authors： Filipovic M,Seeberger MD,Schneider MC,Schmid M,Pargger H,Hunziker P,Skarvan K

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:There is growing interest in the effect of postoperative analgesics on oncological outcomes after cancer surgery. We investigated the impact of tramadol after breast cancer surgery on recurrence and mortality and explored the mechanism by which tramadol affects cultured breast cancer cells in vitro. METHODS...

journal_title：British journal of anaesthesia

authors： Kim MH,Oh JE,Park S,Kim JH,Lee KY,Bai SJ,Song H,Hwang HJ,Kim DW,Yoo YC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Inconsistent and poorly coordinated systems of tracheostomy care commonly result in frustrations, delays, and harm. Quality improvement strategies described by exemplar hospitals of the Global Tracheostomy Collaborative have potential to mitigate such problems. This 3 yr guided implementation programme inves...

journal_title：British journal of anaesthesia

authors： McGrath BA,Wallace S,Lynch J,Bonvento B,Coe B,Owen A,Firn M,Brenner MJ,Edwards E,Finch TL,Cameron T,Narula A,Roberson DW

更新日期：2020-07-01 00:00:00

abstract：:The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery (trapeziectomy). Further investigations revealed a lifelong history...

journal_title：British journal of anaesthesia

authors： Habib AM,Okorokov AL,Hill MN,Bras JT,Lee MC,Li S,Gossage SJ,van Drimmelen M,Morena M,Houlden H,Ramirez JD,Bennett DLH,Srivastava D,Cox JJ

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Early postoperative negative behaviour in preschool children after general anaesthesia is a common problem. The distinction between emergence delirium (ED) and pain is difficult, but management differs between the two. The aim of the current analysis was to identify individual observational variables that ca...

journal_title：British journal of anaesthesia

authors： Somaini M,Engelhardt T,Fumagalli R,Ingelmo PM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:We investigated the effects of total i.v. anaesthesia (TIVA) and balanced anaesthesia (BAL) with sevoflurane on postoperative lung function in patients undergoing surgery in the prone position. METHODS:Sixty patients, aged 21-60 yr, undergoing elective lumbar disc surgery in the prone position were randomly...

journal_title：British journal of anaesthesia

authors： Tiefenthaler W,Pehboeck D,Hammerle E,Kavakebi P,Benzer A

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Signalling of several G-protein-coupled receptors of the Gq/11 family is time-dependently inhibited by local anaesthetics (LAs). Since LA-induced modulation of muscarinic m1 and m3 receptor function may explain their beneficial effects in clinical practice, such as decreased postoperative cognitive dysfuncti...

journal_title：British journal of anaesthesia

authors： Picardi S,Stevens MF,Hahnenkamp K,Durieux ME,Lirk P,Hollmann MW

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Cerebral state index (CSI) has recently been introduced as an intra-operative monitor of anaesthetic depth. We compared the performance of the CSI to the bispectral index (BIS) in measuring depth of anaesthesia during target-controlled infusion (TCI) of propofol. METHODS:Twenty Chinese patients undergoing g...

journal_title：British journal of anaesthesia

authors： Zhong T,Guo QL,Pang YD,Peng LF,Li CL

更新日期：2005-12-01 00:00:00

abstract：:Protein kinase C (PKC) is a key regulatory enzyme that has been implicated as a molecular target for the action of general anaesthetics. We have determined the effects of halothane on the translocation and down-regulation of conventional PKC (cPKC) by analysing the subcellular distribution of PKC activity, [3H]phorbol...

journal_title：British journal of anaesthesia

authors： Hemmings HC Jr,Adamo AI

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anaesthetic. An alternative is topical anaesthesia, such as Rapydan which is a novel topical anaesthetic patch containing 70 mg each of lidocaine and tetraca...

journal_title：British journal of anaesthesia

authors： Ruetzler K,Sima B,Mayer L,Golescu A,Dunkler D,Jaeger W,Hoeferl M,You J,Sessler DI,Grubhofer G,Hutschala D

更新日期：2012-11-01 00:00:00

abstract：:The evidence for an association between hypertensive disease, elevated admission arterial pressure, and perioperative cardiac outcome is reviewed. A systematic review and meta-analysis of 30 observational studies demonstrated an odds ratio for the association between hypertensive disease and perioperative cardiac outc...

journal_title：British journal of anaesthesia

authors： Howell SJ,Sear JW,Foëx P

更新日期：2004-04-01 00:00:00

abstract：:Regional haemodynamic control by the cardiovascular baroreceptors was examined in dogs anaesthetized with 1 + MAC halothane in oxygen (1%). The open-loop relationships between carotid sinus pressure (CSP) and regional haemodynamics in the iliac, renal, mesenteric, aortic and coeliac beds were examined before vagotomy,...

journal_title：British journal of anaesthesia

authors： Bagshaw RJ,Cox RH

更新日期：1977-06-01 00:00:00