Abstract:
:We have examined the role of gamma-aminobutyric acid (GABA) neurones in propofol anaesthesia in mice using the righting reflex. Propofol i.p. increased the percentage of loss of the righting reflex in a dose-dependent manner with an ED50 value of 140 (95% confidence limits 123-160) mg kg-1 (n = 40; eight animals per dose, five doses per dose-response curve). The ED50 for propofol decreased significantly to 66 (58-75) mg kg-1 in the presence of the GABAA receptor agonist muscimol 1 mg kg-1 i.p. (n = 40) (P < 0.05). In contrast, the ED50 increased significantly to 240 (211-274) mg kg-1 in the presence of the antagonist bicuculline 5 mg kg-1 i.p. (n = 40) (P < 0.05). Our results suggest that propofol anaesthesia may be mediated, at least in part by GABA neurons.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Irifune M,Sugimura M,Takarada T,Maeoka K,Shimizu Y,Dohi T,Nishikawa T,Kawahara Mdoi
10.1093/bja/83.4.665subject
Has Abstractpub_date
1999-10-01 00:00:00pages
665-7issue
4eissn
0007-0912issn
1471-6771pii
S0007-0912(17)38310-1journal_volume
83pub_type
杂志文章abstract::For 6 months after renal transplant serum cholinesterase concentrations were measured in 10 patients. The value decreased in the first 15 days after operation, but was normal thereafter. Liver function tests were normal throughout the study; the cholinesterase changes were independent of immunosuppressive therapy. ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/51.9.881
更新日期:1979-09-01 00:00:00
abstract::We have compared the effects of progressive (30% and 60%) in vitro haemodilution with hydroxyethyl starch (HES), gelatin (GEL) and albumin (ALB) with haemodilution using 0.9% saline in 96 patients by thrombelastography. Haemodilution with HES, GEL and ALB significantly (P < 0.05) compromised coagulation time (k), angl...
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doi:10.1093/bja/78.6.684
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anaesthetic. An alternative is topical anaesthesia, such as Rapydan which is a novel topical anaesthetic patch containing 70 mg each of lidocaine and tetraca...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-01 00:00:00
abstract::This case series presents 10 patients undergoing vascular surgery with asymptomatic elevated high-sensitivity troponin T concentrations, measured at outpatient clinic before surgery. Patients were included in the RAVE (Rotterdam Antiplatelet therapy in Vascular patiEnts) pilot study. All included patients underwent co...
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更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate whether reversal of rocuronium-induced neuromuscular blockade with sugammadex reduced the incidence of residual blockade and facilitated operating room discharge readiness. METHODS:Adult patients undergoing abdominal surgery received rocuronium, followed by randomized allocat...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1093/bja/aev104
更新日期:2015-11-01 00:00:00
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journal_title:British journal of anaesthesia
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更新日期:2006-12-01 00:00:00
abstract::The effects of the i.v. infusion of insulin, 70 mu. kg-1h-1 for the first 60 min and 35 mu. kg-1h-1 subsequently, on the metabolic and endocrine responses to gynaecological surgery were investigated. In comparison with a control group of patients, the insulin infusion caused a marked decrease in circulating glucose, n...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-10-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章,多中心研究
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更新日期:2010-12-01 00:00:00
abstract::We have determined the effect of pretreatment with mivacurium on the potency of suxamethonium and the effect of prior administration of suxamethonium on the potency of mivacurium. We studied 100 ASA I or II patients during thiopentone-fentanyl-nitrous oxide-isoflurane anaesthesia. Neuromuscular block was recorded as t...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-01-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-11-01 00:00:00
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更新日期:2002-12-01 00:00:00
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journal_title:British journal of anaesthesia
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章
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更新日期:1990-08-01 00:00:00
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journal_title:British journal of anaesthesia
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更新日期:1992-02-01 00:00:00
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更新日期:2016-12-01 00:00:00
abstract::The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aei075
更新日期:2005-04-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/65.2.268
更新日期:1990-08-01 00:00:00