Plain bupivacaine: an unpredictable spinal anaesthetic agent.

Abstract:

:Plain bupivacaine 0.5% or 0.75% was injected intrathecally in four groups of 10 patients. Group A received 0.75% bupivacaine 2.7 ml at L3/4, group B 0.5% bupivacaine 4 ml at L3/4, group C 0.75% bupivacaine 2.7 ml at L2/3 and group D 0.75% bupivacaine 2 ml at L3/4. A very wide range of height of block was found in each group and because of this there were few statistically significant differences between the groups. The mean height of anaesthetic blockade was significantly higher when 20 mg (group C) was injected compared with 15 mg (group D). Decreasing the volume of injection from 4 ml (group B) to 2.7 ml (group A) did not decrease this variability. By injecting at L2/3 spinal space (group C) the mean maximum level of anaesthesia (T7) was four segments higher than group A (T11) injected at L3/4, and this was reflected in a greater incidence of arterial hypotension.

journal_name

Br J Anaesth

authors

Logan MR,McClure JH,Wildsmith JA

doi

10.1093/bja/58.3.292

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

292-6

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)37846-7

journal_volume

58

pub_type

临床试验,杂志文章,随机对照试验
  • Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.

    abstract::In rats injected s.c. with formalin, behavioural correlates of the amount and pattern of Fos-like immunoreactivity (Fos-Ll) (molecular responses to pain) were studied to test if early phase treatment with 75% nitrous oxide or 2% halothane, or both, suppressed subsequent spinal sensitization. Rats were allocated to fou...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.1.99

    authors: Sun WZ,Shyu BC,Shieh JY

    更新日期:1996-01-01 00:00:00

  • Caesarean section associated with gross obesity.

    abstract::The anaesthetic and surgical problems associated with Caesarean section in eight grossly obese patients (weight 150-204 kg) are described. In addition to an increase in the frequency and severity of the complications of obesity, those weighing more than 150 kg present a panniculus which may weigh 70 kg. Extradural ana...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.9.919

    authors: Hodgkinson R,Husain FJ

    更新日期:1980-09-01 00:00:00

  • Oxygen consumption and delivery relationship in brain-dead organ donors.

    abstract::The oxygen delivery (DO2) and consumption (VO2) relationship in brain-dead organ donors is unknown. Therefore, in a prospective study, we determined the DO2/VO2 relationship in 21 consecutive brain-dead patients. Patients were allocated to one of two groups, according to plasma lactate concentration: normal (group NL,...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.6.783

    authors: Langeron O,Couture P,Mateo J,Riou B,Pansard JL,Coriat P

    更新日期:1996-06-01 00:00:00

  • Tube tip and cuff position using different strategies for placement of currently available paediatric tracheal tubes.

    abstract:BACKGROUND:Tracheal tube tip and cuff positions of different cuffed paediatric tracheal tube brands in the trachea can vary with design. METHODS:Data from three clinical studies with measured tracheal lengths were pooled in a database including 422 children aged from birth to 16 yr. Dimensional data of seven cuffed pa...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.05.002

    authors: Kemper M,Imach S,Buehler PK,Thomas J,Dave M,Weiss M

    更新日期:2018-08-01 00:00:00

  • Viability criterion of muscle bundles used in the in vitro contracture test in patients with neuromuscular diseases.

    abstract::We have compared the viability criteria of muscle bundles used in the in vitro contracture test for susceptibility to malignant hyperthermia (MH) in a group of 28 patients with various neuromuscular diseases (NMD) and 93 MH-related family patients. In the patients with NMD, this standard test gave one positive, six eq...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/72.1.93

    authors: Adnet PJ,Krivosic-Horber RM,Krivosic I,Haudecoeur G,Reyford HG,Adamantidis MM,Medahoui H

    更新日期:1994-01-01 00:00:00

  • High frequency jet ventilation v. manual jet ventilation during bronchoscopy in patients with tracheo-bronchial stenosis.

    abstract::Six patients with airway stenosis were submitted to bronchoscopy under general anaesthesia. Each was ventilated with a gas mixture of 50% oxygen and nitrogen using successively manual jet insufflation (JV) using the Sanders technique at 20 b.p.m., and high frequency jet ventilation (HFJV) at rates of 150, 300 and 500 ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/55.10.969

    authors: Vourc'h G,Fischler M,Michon F,Melchior JC,Seigneur F

    更新日期:1983-10-01 00:00:00

  • Estimation of arterial PCO2 during high frequency jet ventilation. Studies in the dog.

    abstract::The arterial to end-tidal PCO2 difference (PaCO2-PE'CO2) was measured in five anaesthetized dogs during controlled ventilation at 0.25 Hz (15 b.p.m.) and during high frequency jet ventilation at 1, 3 and 5 Hz. Because of the slow response of the infra-red carbon dioxide analyser, satisfactory recordings of end-tidal c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.2.240

    authors: Mortimer AJ,Cannon DP,Sykes MK

    更新日期:1987-02-01 00:00:00

  • General anaesthesia for caesarean section in severe pre-eclampsia. Comparison of the renal and hepatic effects of enflurane and halothane.

    abstract::In a randomized study of patients undergoing Caesarean section, either enflurane (mean 0.24 MAC-h) or halothane (mean 0.23 MAC-h) and 50% nitrous oxide in oxygen were administered to women (n = 12) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function. No eviden...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/56.6.587

    authors: Crowhurst JA,Rosen M

    更新日期:1984-06-01 00:00:00

  • Recovery after total intravenous general anaesthesia or spinal anaesthesia for total knee arthroplasty: a randomized trial.

    abstract:BACKGROUND:This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS:One hundred and twenty subjects were randomly alloca...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aet104

    authors: Harsten A,Kehlet H,Toksvig-Larsen S

    更新日期:2013-09-01 00:00:00

  • Extrafascial injection for interscalene brachial plexus block reduces respiratory complications compared with a conventional intrafascial injection: a randomized, controlled, double-blind trial.

    abstract:BACKGROUND:Hemidiaphragmatic paresis after ultrasound-guided interscalene brachial plexus block is reported to occur in up to 100% of patients. We tested the hypothesis that an injection lateral to the brachial plexus sheath reduces the incidence of hemidiaphragmatic paresis compared with a conventional intrafascial in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aew028

    authors: Palhais N,Brull R,Kern C,Jacot-Guillarmod A,Charmoy A,Farron A,Albrecht E

    更新日期:2016-04-01 00:00:00

  • Differential effects of desflurane and halothane on peripheral airway smooth muscle.

    abstract::Volatile anaesthetics have been shown to have direct relaxant effects on airway smooth muscle. We have examined the effects of 0.9, 1.9, and 2.8 dog MAC of desflurane and halothane on isolated proximal and distal canine airways precontracted with acetylcholine. The proximal and distal airway smooth muscle relaxed with...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.6.841

    authors: Mazzeo AJ,Cheng EY,Bosnjak ZJ,Coon RL,Kampine JP

    更新日期:1996-06-01 00:00:00

  • Epidural analgesia in a child with sickle cell disease complicated by acute abdominal pain and priapism.

    abstract::We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/87.6.935

    authors: Labat F,Dubousset AM,Baujard C,Wasier AP,Benhamou D,Cucchiaro G

    更新日期:2001-12-01 00:00:00

  • A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia.

    abstract::A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/48.5.469

    authors: Gjessing J,Barsa J,Tomlin PJ

    更新日期:1976-05-01 00:00:00

  • Termination of supraventricular tachycardia by propofol.

    abstract::It is known that propofol can have effects on atrioventricular node conduction. We report a case where administration of propofol was associated with termination of supraventricular tachycardia. Although a similar phenomenon has been reported in children, this is the first such case in an adult. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:

    authors: Kannan S,Sherwood N

    更新日期:2002-06-01 00:00:00

  • Effects of midazolam on insulin secretion from isolated rat pancreatic islets of Langerhans.

    abstract::Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenaline 10 mumol litre-1 was used as a control. In contrast with noradrenaline...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.2.221

    authors: Desborough JP,Jones PM,Persaud SJ,Howell SL

    更新日期:1993-02-01 00:00:00

  • Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.

    abstract:BACKGROUND:Low fibrinogen (Fg) concentrations in trauma haemorrhage are associated with poorer outcomes. Cryoprecipitate is the standard source for Fg administration in the UK and USA and is often given in the later stages of transfusion therapy. It is not known whether early cryoprecipitate therapy improves clinical o...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev134

    authors: Curry N,Rourke C,Davenport R,Beer S,Pankhurst L,Deary A,Thomas H,Llewelyn C,Green L,Doughty H,Nordmann G,Brohi K,Stanworth S

    更新日期:2015-07-01 00:00:00

  • Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loops.

    abstract:BACKGROUND:Left ventricular (LV) pressure-volume (PV) loops were used to compare the functional effects that accompany the cardioprotection seen with desflurane, sevoflurane, and propofol in a rabbit preparation of coronary ischaemia-reperfusion (IR). METHODS:Male New Zealand White rabbits (n=48) were anaesthetized wi...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aep238

    authors: Andrews DT,Royse AG,Royse CF

    更新日期:2009-11-01 00:00:00

  • Determination of cardiac output by ultrasound dilution technique in infants and children: a validation study against direct Fick principle.

    abstract:BACKGROUND:In critically ill children, monitoring of cardiac output (CO) is essential to guide haemodynamic management and facilitate cardiovascular therapy. The ultrasound dilution technique (UDT), a novel minimally invasive indicator method, was recently introduced to determine CO. We validated UDT against the 'gold ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aet382

    authors: Boehne M,Baustert M,Paetzel V,Köditz H,Schoof S,Happel CM,Bertram H

    更新日期:2014-03-01 00:00:00

  • Lipid solubility of pancuronium and vecuronium determined by n-octanol/water partitioning.

    abstract::We have measured the n-octanol/water distribution coefficients at 37 degrees C of two steroidal myoneural blockers (pancuronium and vecuronium) and of their 3-hydroxy metabolites over a pH range from 1.5 to 11. Pancuronium was found not to be lipid soluble. The mean distribution coefficient of 3-hydroxy vecuronium at ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.5.579

    authors: Weindlamayr-Goettel M,Gilley H,Sipos E,Steinbereithner K

    更新日期:1993-05-01 00:00:00

  • Review of perioperative falls.

    abstract::Falls are a known public health problem, and there is increasing recognition of the importance of perioperative falls for risk prediction and quality assessment. Our objective was to review existing literature regarding the occurrence, injuries, and risk factors of preoperative and postoperative falls. A systematized ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aew377

    authors: Kronzer VL,Wildes TM,Stark SL,Avidan MS

    更新日期:2016-12-01 00:00:00

  • Comparison of two induction regimens using or not using muscle relaxant: impact on postoperative upper airway discomfort.

    abstract:BACKGROUND:Muscle relaxants facilitate tracheal intubation, but they are often not used for short peripheral surgical procedures. The consequences of this practice on the upper airway are still a matter of controversy. We therefore compared the incidence of post-intubation symptoms in a randomized study comparing patie...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aem147

    authors: Combes X,Andriamifidy L,Dufresne E,Suen P,Sauvat S,Scherrer E,Feiss P,Marty J,Duvaldestin P

    更新日期:2007-08-01 00:00:00

  • Pharmacokinetics of glycopyrronium in uraemic patients.

    abstract::We studied the pharmacokinetics of glycopyrronium in 11 uraemic patients undergoing cadaveric renal transplantation and in seven ASA I control patients undergoing general surgery. Glycopyrronium 4 micrograms kg-1 was given i.v. before induction of anaesthesia. Blood and urine samples were collected for up to 24 h for ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/71.3.437

    authors: Kirvelä M,Ali-Melkkilä T,Kaila T,Iisalo E,Lindgren L

    更新日期:1993-09-01 00:00:00

  • Efficacy of low-dose bupivacaine in spinal anaesthesia for Caesarean delivery: systematic review and meta-analysis.

    abstract::Spinal anaesthesia is the preferred anaesthetic technique for elective Caesarean deliveries. Hypotension is the most common side-effect and has both maternal and neonatal consequences. Different strategies have been attempted to prevent spinal-induced hypotension, including the use of low-dose bupivacaine. We conducte...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aer200

    authors: Arzola C,Wieczorek PM

    更新日期:2011-09-01 00:00:00

  • Soluble E-cadherin concentrations in patients with systemic inflammatory response syndrome and multiorgan dysfunction syndrome.

    abstract::We have assessed the role of the cell-cell adhesion molecule, E-cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE-cadherin) was measured by enzyme immunoassay. The medi...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.5.629

    authors: Pittard AJ,Banks RE,Galley HF,Webster NR

    更新日期:1996-05-01 00:00:00

  • Anaesthesia for surgery in a patient with a transplanted heart.

    abstract::Five-year survival following cardiac transplantation approaches 50% and such patients occasionally present for non-cardiac surgery. The application of a simple general anaesthetic technique is described in a patient undergoing minor surgery, and the problems involved in managing heart transplant recipients are discuss...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.6.634

    authors: Bricker SR,Sugden JC

    更新日期:1985-06-01 00:00:00

  • Gram stain of bronchoalveolar lavage fluid in the early diagnosis of ventilator-associated pneumonia.

    abstract::To assess the usefulness of the Gram stain in the early diagnosis of ventilator-associated pneumonia (VAP), we performed 146 protected specimen brushings (PSB) and bronchoalveolar lavages (BAL) in 118 patients suspected of having nosocomial pneumonia. Gram stain and counts of infected cells were performed in all sampl...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/83.6.845

    authors: Allaouchiche B,Jaumain H,Chassard D,Boulétreau P

    更新日期:1999-12-01 00:00:00

  • Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.

    abstract:Background:Retrospective clinical studies suggest there is a risk for neurodevelopmental impairment following early childhood exposure to anaesthesia. In the developing animal brain, including those of non-human primates (NHPs), anaesthetics induce apoptotic cell death. We previously reported that a 5 h isoflurane (ISO...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aex123

    authors: Noguchi KK,Johnson SA,Dissen GA,Martin LD,Manzella FM,Schenning KJ,Olney JW,Brambrink AM

    更新日期:2017-09-01 00:00:00

  • Four phases of intravenous fluid therapy: a conceptual model.

    abstract::I.V. fluid therapy plays a fundamental role in the management of hospitalized patients. While the correct use of i.v. fluids can be lifesaving, recent literature demonstrates that fluid therapy is not without risks. Indeed, the use of certain types and volumes of fluid can increase the risk of harm, and even death, in...

    journal_title:British journal of anaesthesia

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1093/bja/aeu300

    authors: Hoste EA,Maitland K,Brudney CS,Mehta R,Vincent JL,Yates D,Kellum JA,Mythen MG,Shaw AD,ADQI XII Investigators Group.

    更新日期:2014-11-01 00:00:00

  • Safe use of remifentanil in a patient treated with the monoamine oxidase inhibitor phenelzine.

    abstract::We report the safe use of remifentanil as part of the anaesthetic technique in a patient undergoing major head and neck surgery who was being treated for depressive illness with the non-specific monoamine oxidase inhibitor (MAOI) phenelzine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.bja.a013453

    authors: Ure DS,Gillies MA,James KS

    更新日期:2000-03-01 00:00:00

  • Intraoperative therapeutic suggestions in day-case surgery: are there benefits for postoperative outcome?

    abstract::To determine if improved postoperative recovery in surgical inpatients receiving intraoperative therapeutic suggestions are applicable in an outpatient population, 70 consenting, unpremedicated adults undergoing elective outpatient hernia repair under general anaesthesia were allocated randomly to either a therapeutic...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/82.6.861

    authors: Lebovits AH,Twersky R,McEwan B

    更新日期:1999-06-01 00:00:00