General anaesthesia for caesarean section in severe pre-eclampsia. Comparison of the renal and hepatic effects of enflurane and halothane.

Abstract:

:In a randomized study of patients undergoing Caesarean section, either enflurane (mean 0.24 MAC-h) or halothane (mean 0.23 MAC-h) and 50% nitrous oxide in oxygen were administered to women (n = 12) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function. No evidence of nephrotoxicity was found in any pre-eclamptic or normal patient. Metabolism of enflurane resulted in plasma inorganic fluoride concentrations (max 15 mumol litre -1) which were well below the toxic value. Postoperative liver function tests showed no important changes from preoperative values, although reductive metabolites of halothane were not measured. In patients with severe pre-eclampsia there appears no contraindication to enflurane or, probably, halothane as volatile supplements during general anaesthesia.

journal_name

Br J Anaesth

authors

Crowhurst JA,Rosen M

doi

10.1093/bja/56.6.587

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

587-97

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)42315-4

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验
  • An evaluation of procaine in the treatment of malignant hyperpyrexia.

    abstract::Procaine has been advocated in the treatment of malignant hyperpyrexia, whereas lignocaine has been shown to worsen the condition. Using muscle from patients susceptible to malignant hyperpyrexia in vitro, it has been demonstrated that muscle contracture can occur with procaine on its own, and in one patient the halot...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.1.17

    authors: Clarke IM,Ellis FR

    更新日期:1975-01-01 00:00:00

  • Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation.

    abstract:BACKGROUND:Anaesthetics blunt neuronal responses to noxious stimulation, including effects on electroencephalographic (EEG) responses. It is unclear how anaesthetics differ in their ability to modulate noxious stimulation-evoked EEG activation. We investigated the actions of propofol and halothane on EEG responses to n...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei208

    authors: Orth M,Barter L,Dominguez C,Atherley R,Carstens E,Antognini JF

    更新日期:2005-10-01 00:00:00

  • End-tidal carbon dioxide concentration as an indicator of pulmonary blood flow during closed heart surgery in children. A report of two cases.

    abstract::The value of the continuous monitoring of end-tidal carbon dioxide concentration as an indicator of the acute intraoperative interruption of pulmonary blood flow, in patients with pre-existing restrictions of pulmonary blood flow undergoing closed heart surgery, is illustrated by two case reports. Decreases in end-tid...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.12.1257

    authors: Schuller JL,Bovill JG,Nijveld A

    更新日期:1985-12-01 00:00:00

  • Recordings of, and an anatomical explanation for, false positive loss of resistance during lumbar extradural analgesia.

    abstract::Loss of resistance dorsal to the ligamentum flavum was recorded in 10 of 16 patients aged 43--75 yr whilst performing extradural anaesthesia at the L2--3 interspace via the midline approach. Degeneration of the interspinous ligament with cavity formation is observed frequently in the elderly and may account for false ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.3.253

    authors: Sharrock NE

    更新日期:1979-03-01 00:00:00

  • Evaluation of flexible (part-time) training in anaesthesia.

    abstract::One hundred and six former or current flexible trainees in anaesthesia responded to a questionnaire evaluating their part-time training (a response rate of 71%). They were compared with a group of 32 flexible trainees in obstetrics and gynaecology. Anaesthetists were more satisfied than obstetricians and gynaecologist...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/81.2.268

    authors: Scriven PM

    更新日期:1998-08-01 00:00:00

  • Comparison of success rates, learning curves, and inter-subject performance variability of robot-assisted and manual ultrasound-guided nerve block needle guidance in simulation.

    abstract:BACKGROUND:This study focuses on a recently developed robotic nerve block system and its impact on learning regional anaesthesia skills. We compared success rates, learning curves, performance times, and inter-subject performance variability of robot-assisted vs manual ultrasound (US)-guided nerve block needle guidance...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aet440

    authors: Morse J,Terrasini N,Wehbe M,Philippona C,Zaouter C,Cyr S,Hemmerling TM

    更新日期:2014-06-01 00:00:00

  • Ultrasonographic guidance for sciatic and femoral nerve blocks in children.

    abstract:BACKGROUND:Recent studies have shown that ultrasound guidance for paediatric regional anaesthesia can improve the quality of upper extremity and neuraxial blocks. We therefore investigated whether ultrasound guidance for sciatic and femoral nerve blocks prolongs sensory blockade in comparison with nerve stimulator guid...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aem092

    authors: Oberndorfer U,Marhofer P,Bösenberg A,Willschke H,Felfernig M,Weintraud M,Kapral S,Kettner SC

    更新日期:2007-06-01 00:00:00

  • Effect of baricity on spinal anaesthesia with amethocaine.

    abstract::Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/52.6.589

    authors: Brown DT,Wildsmith JA,Covino BG,Scott DB

    更新日期:1980-06-01 00:00:00

  • Effect of volatile anaesthetics on cell survival as measured by colony forming ability.

    abstract::Chinese hamster fibroblast cells in stirred suspension cultures were exposed to volatile anaesthetic agents for 3 hr or for 24 hr. Cell viability was measured as colony forming ability and was found to be reduced, in a dose related manner, by halothane, chloroform, methoxyflurane, trichloroetheylene and diethyl ether....

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.8.831

    authors: Sturrock JE

    更新日期:1975-08-01 00:00:00

  • Effect of a mixture of pyridostigmine and atropine on forced expiratory volume (FEV1), and serum cholinesterase activity in normal subjects.

    abstract::Pyridostigmine 0.143 mg kg-1 (maximum 10 mg) and atropine 0.0143 mg kg-1 (maximum 1 mg) were administered i.v. to six healthy male volunteers. Peripheral venous blood samples were drawn for measurement of serum cholinesterase activity. Maximum inhibition of the enzyme was found 5 min after injection with a decrease to...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.2.204

    authors: Feldt-Rasmussen BF,Gefke K,Mosbech H,Hanel HK

    更新日期:1985-02-01 00:00:00

  • Electrical stimulation in chronic low-back pain.

    abstract::Since 1972, 367 patients with chronic low-back pain have been treated by electrical stimulation (e.s.). Patients with herniated disc lesions and spondylitis and allied conditions were included. Following e.s. 75-100% pain relief was obtained by 53% of the patients 50% pain relief by 27% and there was no improvement in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.6.629

    authors: Rutkowski B,Niedzialkowska T,Otto J

    更新日期:1977-06-01 00:00:00

  • The proseal laryngeal mask: results of a descriptive trial with experience of 300 cases.

    abstract:BACKGROUND:The ProSeal laryngeal mask airway (PLMA) is a new laryngeal mask device with a modified cuff and a drainage tube. METHODS:We assessed the PLMA in 300 anaesthetized adults either paralysed or breathing spontaneously. We assessed insertion characteristics, airway seal pressures, haemodynamic response to inser...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/88.4.534

    authors: Evans NR,Gardner SV,James MF,King JA,Roux P,Bennett P,Nattrass R,Llewellyn R,Visu D

    更新日期:2002-04-01 00:00:00

  • Comparison between single-step and balloon dilatational tracheostomy in intensive care unit: a single-centre, randomized controlled study.

    abstract:BACKGROUND:Balloon dilatational tracheostomy using the Ciaglia Blue Dolphin device has recently been introduced as a modification of the Ciaglia technique. The aim of this study was to compare the new Dolphin system with the single-step dilatational tracheostomy (Ciaglia Blue Rhino) in intensive care unit (ICU) patient...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aeq087

    authors: Cianchi G,Zagli G,Bonizzoli M,Batacchi S,Cammelli R,Biondi S,Spina R,Peris A

    更新日期:2010-06-01 00:00:00

  • Sodium nitroprusside and regional arterial haemodynamics in the dog.

    abstract::Blood flow to functionally different vascular beds was examined during a sodium nitroprusside infusion in 10 dogs anaesthetized with halothane (1 MAC) in oxygen. Blood flows were measured in the ascending aorta, and the coeliac, superior mesenteric, renal and iliac arteries. In two dogs, regional vascular impedance an...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.8.735

    authors: Bagshaw RJ,Cox RH,Campbell KB

    更新日期:1977-08-01 00:00:00

  • 4-Aminopyridine reversal of fentanyl-induced respiratory depression in normocapnic and hypercapnic patients.

    abstract::Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2' suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.4.373

    authors: Sia RL,Zandstra DF

    更新日期:1981-04-01 00:00:00

  • A brief historical review of non-anaesthetic causes of fires and explosions in the operating room.

    abstract::Fires and explosions have occurred in the operating theatre for many years. Flammable inhalation anaesthetic agents were responsible for many incidents in the past, but these are no longer available in many countries. Other causes of fires and explosions still exist in the operating theatre and, from time to time, res...

    journal_title:British journal of anaesthesia

    pub_type: 历史文章,杂志文章

    doi:10.1093/bja/73.6.847

    authors: Macdonald AG

    更新日期:1994-12-01 00:00:00

  • Lower oesophageal contractility and detection of awareness during anaesthesia.

    abstract::We have investigated the value of lower oesophageal contractility (LOC) in detecting awareness during anaesthesia in 20 human volunteer patients. LOC was measured either with subjects awake or after induction with propofol, during induction with propofol, and then as consciousness returned. Statistically significant c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/65.3.319

    authors: Isaac PA,Rosen M

    更新日期:1990-09-01 00:00:00

  • Perioperative management of patients with suspected or confirmed COVID-19: review and recommendations for perioperative management from a retrospective cohort study.

    abstract:BACKGROUND:Current guidelines for perioperative management of coronavirus disease 19 (COVID-19) are mainly based on extrapolated evidence or expert opinion. We aimed to systematically investigate how COVID-19 affects perioperative management and clinical outcomes, to develop evidence-based guidelines. METHODS:First, w...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1016/j.bja.2020.08.049

    authors: Zheng H,Hébert HL,Chatziperi A,Meng W,Smith BH,Yan J,Zhou Z,Zhang X,Luo A,Wang L,Zhu W,Hu J,Colvin LA

    更新日期:2020-12-01 00:00:00

  • Intravenous dexamethasone fails to prolong psoas compartment block when assessed by objective pinprick sensory testing: a prospective, randomised, dose-dependent, placebo-controlled equivalency trial.

    abstract:BACKGROUND:Recent studies have concluded that i.v. dexamethasone can prolong the duration of peripheral nerve blockade. We hypothesized that a 4 mg dose would equally prolong the duration of psoas compartment blocks (PCBs) when compared with 8 mg, and that both doses would prolong the duration when compared with placeb...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bja.2017.11.073

    authors: Turner JD,Dobson SW,Weller RS,Russell GB,Henshaw DS

    更新日期:2018-02-01 00:00:00

  • Resistant hypertension and preoperative silent myocardial ischaemia in surgical patients.

    abstract::We studied 325 patients undergoing elective noncardiac surgery who had preoperative ambulatory ECG monitoring performed for a duration of 5130 h (range 8-24 h; mean 15.8 h). Sixty-four subjects (20%) had one or more episodes of ST segment depression consistent with myocardial ischaemia. Of all preoperative cardiovascu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/73.5.574

    authors: Allman KG,Muir A,Howell SJ,Hemming AE,Sear JW,Foëx P

    更新日期:1994-11-01 00:00:00

  • Therapeutic potential of cannabis in pain medicine.

    abstract::Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance. Cannabinoids (CBs) are chemical compounds derived from cannabis. The major psychotropic CB delta-9-tetrahydrocannabino...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aen119

    authors: Hosking RD,Zajicek JP

    更新日期:2008-07-01 00:00:00

  • Sources of error in partial rebreathing pulmonary blood flow measurements in lungs with emphysema and pulmonary embolism.

    abstract:BACKGROUND:Studies of the accuracy of partial rebreathing measurements of pulmonary blood flow (PBF) in patients with abnormal lungs have not fully explained the sources of error. METHODS:We used computer models of emphysema and pulmonary embolism incorporating both ventilation-perfusion (V/Q) and ventilation-volume (...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael214

    authors: Yem JS,Turner MJ,Baker AB

    更新日期:2006-11-01 00:00:00

  • In vitro diagnosis of malignant hyperthermia: influence of electrical stimulation on the contracture response to caffeine.

    abstract::We have examined the influence of electrical stimulation on caffeine-induced tension generation during contracture testing used to diagnose malignant hyperthermia. The cumulative contracture response to caffeine was compared in pairs of morphologically comparable muscle bundles obtained from the same patient. Only one...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.1.87

    authors: Heytens L,Martin JJ,Bossaert LL

    更新日期:1992-07-01 00:00:00

  • Effect of doxapram on the rate of recovery from atracurium and vecuronium neuromuscular block.

    abstract::We have studied the effect of doxapram on the rates of spontaneous and neostigmine-induced recovery from neuromuscular block with atracurium and vecuronium, by measurement of the time to recovery of T1 (first twitch in the train-of-four) from 25 to 75% of control (recovery index, RI). After each neuromuscular blocking...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/68.5.527

    authors: Cooper R,McCarthy G,Mirakhur RK,Maddineni VR

    更新日期:1992-05-01 00:00:00

  • Ondansetron and droperidol in the prevention of postoperative nausea and vomiting.

    abstract::We have performed a prospective, randomized, double-blind clinical study to assess the efficacy of ondansetron, droperidol, or both, in preventing postoperative emesis. We studied 242 patients undergoing biliary or gynaecological surgery under general anaesthesia. Shortly before induction of anaesthesia, patients rece...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/83.5.813

    authors: Bugedo G,Gonzalez J,Asenjo C,De la Cuadra JC,Gajardo A,Castillo L,Muñoz H,Dagnino J

    更新日期:1999-11-01 00:00:00

  • Psychosocial interventions for managing pain in older adults: outcomes and clinical implications.

    abstract::Interest in the use of psychosocial interventions to help older adults manage pain is growing. In this article, we review this approach. The first section reviews the conceptual background for psychosocial interventions with a special emphasis on the biopsychosocial model of pain. The second section highlights three p...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aet129

    authors: Keefe FJ,Porter L,Somers T,Shelby R,Wren AV

    更新日期:2013-07-01 00:00:00

  • Extradural blood patch--why delay?

    abstract::Seven patients are described in whom a prophylactic blood patch was instituted within 15 min of accidental dural puncture. Five of the patients received extradural anaesthesia before the blood patch, and one after the blood patch had been performed. In three of these patients further "top-up" doses of local anaestheti...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.5.538

    authors: Quaynor H,Corbey M

    更新日期:1985-05-01 00:00:00

  • Suspected opioid-induced hyperalgesia in an infant.

    abstract::One explanation for diminished opioid analgesic efficacy is opioid-induced hyperalgesia (OIH). We report a case of OIH in an infant with gastroschisis, requiring multiple surgical interventions and prolonged sedation for ventilation. This is the first report of OIH in an infant. On day 41 of life after nine separate s...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer332

    authors: Hallett BR,Chalkiadis GA

    更新日期:2012-01-01 00:00:00

  • Comparison of the effectiveness of bilateral ilioinguinal nerve block and wound infiltration for postoperative analgesia after caesarean section.

    abstract::We have studied the effects of bilateral ilioinguinal nerve block and wound infiltration with 0.5% bupivacaine on postoperative pain and analgesic requirements in 62 patients undergoing Caesarean section under general anaesthesia. A control group received no local anaesthetic supplementation. Both ilioinguinal block a...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/72.2.229

    authors: Ganta R,Samra SK,Maddineni VR,Furness G

    更新日期:1994-02-01 00:00:00

  • A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

    abstract::The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy volunteers. No significant change in the ventilatory response to rebreathing carbon dioxide was observed after meptazin...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/51.6.497

    authors: Jordan C,Lehane JR,Robson PJ,Jones JG

    更新日期:1979-06-01 00:00:00