Comparison of speed of onset of analgesic effect of diamorphine and morphine.

abstract：BACKGROUND:The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters. METHODS:Nineteen obese ASA II patients undergoing bariatric surgery were studied. Patients received propofol 2 mg kg(-1) bolus dose followed by a 5-20-40-120 min, 10-8-...

journal_title：British journal of anaesthesia

authors： Cortínez LI,Anderson BJ,Penna A,Olivares L,Muñoz HR,Holford NH,Struys MM,Sepulveda P

更新日期：2010-10-01 00:00:00

abstract：:Arterial PO2 (PaO2) has been related to inspired oxygen concentration (FIO2 range 0.21-0.60) in 20 patients, breathing spontaneously, while recovering from a range of conditions treated in an intensive therapy unit. There was a highly significant linear trend (P < 0.001) for the mean venous admixture ("virtual shunt")...

journal_title：British journal of anaesthesia

authors： Petros AJ,Doré CJ,Nunn JF

更新日期：1994-05-01 00:00:00

abstract：:Dysregulation of the immuno-inflammatory response, as seen in sepsis, may culminate in host cell and organ damage. Lipopolysaccharide from Gram-negative bacterial cell walls induces gene activation and subsequent inflammatory mediator expression. Gene activation is regulated by a number of transcription factors at the...

journal_title：British journal of anaesthesia

authors： Macdonald J,Galley HF,Webster NR

更新日期：2003-02-01 00:00:00

abstract：:We prospectively studied spontaneous recovery from cisatracurium-induced neuromuscular block in 18 patients scheduled for cardiac surgery, and its suitability for fast-track cardiac surgery. Neuromuscular block was induced by an i.v. bolus (range 0.15-0.3 mg kg(-1)) and maintained by a continuous infusion (range 1.1-3...

journal_title：British journal of anaesthesia

authors： Ouattara A,Richard L,Charrière JM,Lanquetot H,Corbi P,Debaene B

更新日期：2001-01-01 00:00:00

abstract：:We studied 40 elderly patients undergoing cataract surgery. Ten non-insulin-dependent diabetes mellitus (NIDDM) patients received standardized general anaesthesia, 10 NIDDM patients received local anaesthesia using retrobulbar block, 10 non-diabetic control patients received general anaesthesia and 10 non-diabetic con...

journal_title：British journal of anaesthesia

authors： Barker JP,Robinson PN,Vafidis GC,Burrin JM,Sapsed-Byrne S,Hall GM

更新日期：1995-05-01 00:00:00

abstract：:Human plasma cholinesterase (E.C. 3.1.1.8) was shown to be inhibited by physiological concentrations of propanidid and suxamethonium using a colourimetric assay at 25 degrees C and pH 7.2 unit with butyrylthiocholine as substrate. Propanidid inhibited the enzyme in a non-competitive manner (I50 = 2.0 mmol litre-1; app...

journal_title：British journal of anaesthesia

authors： Taussig PE,Stojak HE,Bennett NR

更新日期：1979-03-01 00:00:00

abstract：:Midazolam 0.3 mg kg-1 was given as a single dose to three groups of children undergoing cardiac surgery to determine its pharmacokinetic profile in this situation. The first group, undergoing closed heart surgery, received the midazolam during the operation. The other groups underwent cardiopulmonary bypass (CPB) with...

journal_title：British journal of anaesthesia

authors： Mathews HM,Carson IW,Lyons SM,Orr IA,Collier PS,Howard PJ,Dundee JW

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. We assessed the effect of transcutaneous electric acupoint...

journal_title：British journal of anaesthesia

authors： Wang H,Xie Y,Zhang Q,Xu N,Zhong H,Dong H,Liu L,Jiang T,Wang Q,Xiong L

更新日期：2014-06-01 00:00:00

abstract：:The haemodynamic effects of diltiazem were studied in six dogs during fentanyl-nitrous oxide (in oxygen) anaesthesia. A bolus of diltiazem 300 micrograms kg-1 was given, followed by infusions at 30, 60 and 90 micrograms kg-1 min-1 which produced plasma diltiazem concentrations of 392 +/- 30, 908 +/- 54 and 1483 +/- 13...

journal_title：British journal of anaesthesia

authors： Griffin RM,Dimich I,Jurado R,Kaplan JA

更新日期：1988-05-01 00:00:00

abstract：:We have compared the postoperative morphine requirements and analgesic efficacy of four doses of i.m. ketorolac 30 mg administered 6-hourly with placebo in a double-blind study of patients undergoing major or minor orthopaedic surgery. During the 24-h postoperative study period which began at the end of surgery, patie...

journal_title：British journal of anaesthesia

authors： Kinsella J,Moffat AC,Patrick JA,Prentice JW,McArdle CS,Kenny GN

更新日期：1992-07-01 00:00:00

abstract：Background:Identification of statistically reliable outcomes for comparison among anaesthetists is challenging. Time-weighted intraoperative mean arterial pressure <65 mm Hg (AUC 65 ) is associated with increased odds for myocardial damage. We explored retrospectively whether such hypotension before incision was statis...

journal_title：British journal of anaesthesia

authors： Epstein RH,Dexter F,Schwenk ES

更新日期：2017-07-01 00:00:00

abstract：:We describe the perioperative management of a 31-yr-old primipara with Glanzmann's thrombasthenia, who required urgent Caesarean delivery at 33 weeks' gestation. Peripartum haemorrhage was inevitable and was pre-empted by transfusion of multiple blood products, the effects of which were monitored by Thrombelastograph....

journal_title：British journal of anaesthesia

authors： Monte S,Lyons G

更新日期：2002-05-01 00:00:00

abstract：:We report two patients who developed skin necrosis following an intramuscular injection of non-steroidal anti-inflammatory drug into the anteriolateral area of their thigh. Both patients required further multiple operations and one developed life threatening septicaemia. They were left with disfiguring scars. Skin nec...

journal_title：British journal of anaesthesia

authors： McGee AM,Davison PM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:We defined the nature of the pharmacological interaction after intrathecal co-administration of ginsenosides with clonidine, and clarified the contribution of the α-2 adrenoceptors on the effect of ginsenosides. METHODS:Pain was evoked by injection of a formalin solution (5%, 50 μl) into the hindpaw of male...

journal_title：British journal of anaesthesia

authors： Yoon MH,Huang LJ,Choi JI,Lee HG,Kim WM,Kim CM

更新日期：2011-03-01 00:00:00

abstract：:This is the report of a 55-yr-old female who developed severe myotonia and dystonia after general anaesthesia. Before starting on gabapentin therapy for a neuropathic pain condition, she had undergone numerous uneventful general anaesthetics. Since receiving treatment with gabapentin, she has experienced severe moveme...

journal_title：British journal of anaesthesia

authors： Allford MA

更新日期：2007-08-01 00:00:00

abstract：:In theory, setting an infrared multi-gas analyser to measure a volatile anaesthetic different from that in the sampled gas mixture may cause interference with carbon dioxide and nitrous oxide readings. The theory was investigated during evaluation of the Dräger Cicero EM anaesthetic workstation for the Medical Devices...

journal_title：British journal of anaesthesia

authors： Wilkes AR,Mapleson WW

更新日期：1996-05-01 00:00:00

abstract：Background:Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. We therefore conducted...

journal_title：British journal of anaesthesia

authors： Nieuwenhuijs-Moeke GJ,Nieuwenhuijs VB,Seelen MAJ,Berger SP,van den Heuvel MC,Burgerhof JGM,Ottens PJ,Ploeg RJ,Leuvenink HGD,Struys MMRF

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The solubility of desflurane compared with sevoflurane suggests more rapid recovery from desflurane anaesthesia. This could be important after prolonged anaesthesia and fast recovery may be advantageous in the elderly where slow recovery of mental function is a concern. We compared emergence from desflurane ...

journal_title：British journal of anaesthesia

authors： Heavner JE,Kaye AD,Lin BK,King T

更新日期：2003-10-01 00:00:00

abstract：:Abnormal oxygen use and organ failure in the critically ill may result from 'poisoning' of mitochondrial function. Measurement of arterial ketone body ratio (AKBR) has been proposed to reflect mitochondrial redox state and may provide a useful marker to monitor mitochondrial function in the critically ill. We measured...

journal_title：British journal of anaesthesia

authors： Yassen KA,Galley HF,Lee A,Webster NR

更新日期：1999-08-01 00:00:00

abstract：:We have compared the effects of inhalation of aerosolized surfactant on experimental acute respiratory distress syndrome. Escherichia coli endotoxin (55 (SD 20) mg kg(-1)) was injected into the tracheas of 36 adult rats anaesthetized and mechanically ventilated with pure oxygen. When the Pa(O(2)) decreased to 11.3 (3....

journal_title：British journal of anaesthesia

authors： Tashiro K,Yamada K,Konzaki T,Yamamoto K,Ohmura S,Kobayashi T,Suzuki Y

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Single preoperative gabapentinoid (gabapentin and pregabalin) administration has been associated with respiratory depression during Phase I anaesthesia recovery. In this study, we assess for associations between chronic (home) use and perioperative administration (preoperative and postoperative) of gabapenti...

journal_title：British journal of anaesthesia

authors： Deljou A,Hedrick SJ,Portner ER,Schroeder DR,Hooten WM,Sprung J,Weingarten TN

更新日期：2018-04-01 00:00:00

abstract：:A specific technique for detection of pulmonary aspiration during the perioperative period is lacking. In this study, we developed a scintigraphic method for its diagnosis. Technetium 99m sulphur colloid was given orally 2 h before an i.v. infusion of propofol in patients undergoing elective colonoscopy. During the pr...

journal_title：British journal of anaesthesia

authors： Rezaiguia-Delclaux S,Streich B,Bouleau D,Delchier JC,Dhonneur G,Meignan M,Duvaldestin P

更新日期：2001-08-01 00:00:00

abstract：:We have recently reported that continuous administration of butorphanol into the brachial plexus neurovascular sheath provided superior analgesia compared with that obtained with continuous i.v. administration. Furthermore, we found that analgesia was most pronounced when a mixture of mepivacaine and butorphanol was g...

journal_title：British journal of anaesthesia

authors： Wajima Z,Shitara T,Nakajima Y,Kim C,Kobayashi N,Kadotani H,Adachi H,Ishikawa G,Kaneko K,Inoue T,Ogawa R

更新日期：1997-01-01 00:00:00

abstract：:To understand the cellular and molecular basis of the anaesthetic state, it is important to remember that, in the intact CNS, synapses operate within elaborate nerve networks. From the data presented above, it is evident that block of impulse conduction in presynaptic fibres does not explain the effects of most anesth...

journal_title：British journal of anaesthesia

authors： Pocock G,Richards CD

更新日期：1993-07-01 00:00:00

abstract：:We studied the pharmacokinetics of glycopyrronium in 11 uraemic patients undergoing cadaveric renal transplantation and in seven ASA I control patients undergoing general surgery. Glycopyrronium 4 micrograms kg-1 was given i.v. before induction of anaesthesia. Blood and urine samples were collected for up to 24 h for ...

journal_title：British journal of anaesthesia

authors： Kirvelä M,Ali-Melkkilä T,Kaila T,Iisalo E,Lindgren L

更新日期：1993-09-01 00:00:00

abstract：:We have investigated the effects of propofol on beat-to-beat fluctuations in heart rate, arterial pressure (continuous arterial tonometry) and infrared finger plethysmography in 10 healthy male patients undergoing elective surgery. Administration of Diprivan (propofol 10 mg ml-1) 0.2 ml kg-1, followed by an infusion o...

journal_title：British journal of anaesthesia

authors： Robinson BJ,Buyck HC,Galletly DC

更新日期：1994-08-01 00:00:00

abstract：:We have investigated the effect of a bolus injection of atracurium 0.6 mg kg-1 on the cardiovascular system in 16 patients undergoing aortocoronary bypass surgery. H1- and H2-receptor antagonists were administered to eight patients before the neuromuscular blocker. A standard anaesthetic was used comprising fentanyl, ...

journal_title：British journal of anaesthesia

authors： Adt M,Baumert JH,Reimann HJ

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:There is growing interest in the effect of postoperative analgesics on oncological outcomes after cancer surgery. We investigated the impact of tramadol after breast cancer surgery on recurrence and mortality and explored the mechanism by which tramadol affects cultured breast cancer cells in vitro. METHODS...

journal_title：British journal of anaesthesia

authors： Kim MH,Oh JE,Park S,Kim JH,Lee KY,Bai SJ,Song H,Hwang HJ,Kim DW,Yoo YC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:There are regional differences in the effects of anaesthetics agents and perioperative stimuli on the EEG. We studied the topography of the EEG during induction of anaesthesia and intubation in patients receiving thiopental and fentanyl to document regional electrical brain activity. METHODS:EEG was recorde...

journal_title：British journal of anaesthesia

authors： Rundshagen I,Schröder T,Prichep LS,John ER,Kox WJ

更新日期：2004-01-01 00:00:00

abstract：:Studies with an emulsion formulation of ICI 35 868 (2,6- diisopropylphenol ) indicate that this new formulation has anaesthetic properties in rats and mice, and haemodynamic effects in the mini-pig which are similar to those of the previously available Cremophor formulation. Administration of the emulsion formulation ...

journal_title：British journal of anaesthesia

authors： Glen JB,Hunter SC

更新日期：1984-06-01 00:00:00