Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine.


BACKGROUND:The incidence of pain on injection of propofol remains unacceptably high in children, despite various strategies to reduce it. A new drug formulation of propofol has, in adult studies, been reported to cause less injection pain compared with other propofol solutions. The aim of the present prospective randomized double-blind clinical trial was to compare the incidence of pain-free injection following the use of this new formulation with that following the use of propofol with added lidocaine in children undergoing day case surgery. METHODS:Eighty-three children (age range 2-18 yr) were randomized to receive 3 mg kg(-1) of either Propofol-Lipuro (propofol dissolved in a mixture of medium- and long-chain triglycerides [MCT-LCT]; group pL, n=42) or Diprivan (propofol dissolved in long-chain triglycerides [LCT]) with added lidocaine (0.3 mg kg(-1)) (group pD, n=41). A specially trained nurse anaesthetist assessed the occurrence of injection pain using a four-graded pain scale. RESULTS:Significantly fewer patients had an entirely pain-free propofol injection in group pL (33.3%) than in group pD (61.0%) (P=0.016). CONCLUSIONS:A new MCT-LCT propofol formulation as a plain solution was associated with a higher incidence of injection pain than LCT propofol with added lidocaine when used for induction of anaesthesia in children.


Br J Anaesth


Nyman Y,von Hofsten K,Georgiadi A,Eksborg S,Lönnqvist PA




Has Abstract


2005-08-01 00:00:00














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    abstract::In a randomized study of patients undergoing Caesarean section, either enflurane (mean 0.24 MAC-h) or halothane (mean 0.23 MAC-h) and 50% nitrous oxide in oxygen were administered to women (n = 12) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function. No eviden...

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    pub_type: 临床试验,杂志文章,随机对照试验


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  • Impact of metabolic syndrome in surgical patients: should we bother?

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    authors: Tzimas P,Petrou A,Laou E,Milionis H,Mikhailidis DP,Papadopoulos G

    更新日期:2015-08-01 00:00:00

  • Procedural sedation of elderly patients by emergency physicians: a safety analysis of 740 patients.

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    authors: Homfray G,Palmer A,Grimsmo-Powney H,Appelboam A,Lloyd G

    更新日期:2018-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Murrell JC,Mitchinson SL,Waters D,Johnson CB

    更新日期:2007-03-01 00:00:00

  • Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Cortínez LI,Anderson BJ,Penna A,Olivares L,Muñoz HR,Holford NH,Struys MM,Sepulveda P

    更新日期:2010-10-01 00:00:00

  • Effects of midazolam on insulin secretion from isolated rat pancreatic islets of Langerhans.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Desborough JP,Jones PM,Persaud SJ,Howell SL

    更新日期:1993-02-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Ashurst N,Rout CC,Rocke DA,Gouws E

    更新日期:1996-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Antonio RP,Philbin DM,Savarese JJ

    更新日期:1979-11-01 00:00:00

  • A dose-response study with nalbuphine hydrochloride for pain in patients after upper abdominal surgery.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Pugh GC,Drummond GB

    更新日期:1987-11-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Bricker SR,Sugden JC

    更新日期:1985-06-01 00:00:00

  • Inhalation induction with sevoflurane: a double-blind comparison with propofol.

    abstract::We conducted a randomized, double-blind comparison of 8% sevoflurane and propofol as induction agents for day-case cystoscopy in 102 patients. All patients received an i.v. cannula and breathed oxygen 5 litre min-1. Anaesthesia was induced with propofol i.v. or inhalation of 8% sevoflurane and 10% Intralipid (as a pla...

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thwaites A,Edmends S,Smith I

    更新日期:1997-04-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Davies JR

    更新日期:1978-05-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Briggs LP,Clarke RS,Dundee JW,Moore J,Bahar M,Wright PJ

    更新日期:1981-11-01 00:00:00

  • A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man.

    abstract::The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in thre...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Agoston S,Vermeer GA,Kersten UW,Scaf AH

    更新日期:1978-04-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Yoshizumi J,Marshall RW,Sanders LD,Vickers MD

    更新日期:1993-12-01 00:00:00

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    authors: Ford PN,Thomas I,Cook TM,Whitley E,Peden CJ

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    authors: Chapple DJ,Miller AA,Ward JB,Wheatley PL

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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


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    pub_type: 杂志文章


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