Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine.

Abstract:

BACKGROUND:The incidence of pain on injection of propofol remains unacceptably high in children, despite various strategies to reduce it. A new drug formulation of propofol has, in adult studies, been reported to cause less injection pain compared with other propofol solutions. The aim of the present prospective randomized double-blind clinical trial was to compare the incidence of pain-free injection following the use of this new formulation with that following the use of propofol with added lidocaine in children undergoing day case surgery. METHODS:Eighty-three children (age range 2-18 yr) were randomized to receive 3 mg kg(-1) of either Propofol-Lipuro (propofol dissolved in a mixture of medium- and long-chain triglycerides [MCT-LCT]; group pL, n=42) or Diprivan (propofol dissolved in long-chain triglycerides [LCT]) with added lidocaine (0.3 mg kg(-1)) (group pD, n=41). A specially trained nurse anaesthetist assessed the occurrence of injection pain using a four-graded pain scale. RESULTS:Significantly fewer patients had an entirely pain-free propofol injection in group pL (33.3%) than in group pD (61.0%) (P=0.016). CONCLUSIONS:A new MCT-LCT propofol formulation as a plain solution was associated with a higher incidence of injection pain than LCT propofol with added lidocaine when used for induction of anaesthesia in children.

journal_name

Br J Anaesth

authors

Nyman Y,von Hofsten K,Georgiadi A,Eksborg S,Lönnqvist PA

doi

10.1093/bja/aei156

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

222-5

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)34937-1

journal_volume

95

pub_type

临床试验,杂志文章,随机对照试验
  • General anaesthesia for caesarean section in severe pre-eclampsia. Comparison of the renal and hepatic effects of enflurane and halothane.

    abstract::In a randomized study of patients undergoing Caesarean section, either enflurane (mean 0.24 MAC-h) or halothane (mean 0.23 MAC-h) and 50% nitrous oxide in oxygen were administered to women (n = 12) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function. No eviden...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/56.6.587

    authors: Crowhurst JA,Rosen M

    更新日期:1984-06-01 00:00:00

  • Impact of metabolic syndrome in surgical patients: should we bother?

    abstract::Clinicians inevitably encounter patients who meet the diagnostic criteria for the metabolic syndrome (MetS); these criteria include central obesity, hypertension, atherogenic dyslipidaemia, and hyperglycaemia. Regardless of the variations in its definition, MetS may be associated with adverse outcomes in patients unde...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aev199

    authors: Tzimas P,Petrou A,Laou E,Milionis H,Mikhailidis DP,Papadopoulos G

    更新日期:2015-08-01 00:00:00

  • Procedural sedation of elderly patients by emergency physicians: a safety analysis of 740 patients.

    abstract:BACKGROUND:The elderly are perceived as a high-risk group for procedural sedation. Concern exists regarding the safety of sedation of this patient group by emergency physicians, particularly when using propofol. METHODS:We analysed prospectively collected data on patients aged 75 yr or older undergoing sedation betwee...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.07.038

    authors: Homfray G,Palmer A,Grimsmo-Powney H,Appelboam A,Lloyd G

    更新日期:2018-12-01 00:00:00

  • Comparative effect of thermal, mechanical, and electrical noxious stimuli on the electroencephalogram of the rat.

    abstract:BACKGROUND:Thermal, mechanical, and electrical stimuli are often used in acute pain studies and cause qualitatively different pain sensations. Yet, the comparative electroencephalogram (EEG) changes caused by these stimuli have not been studied. We hypothesized that because these stimuli cause different pain sensations...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael377

    authors: Murrell JC,Mitchinson SL,Waters D,Johnson CB

    更新日期:2007-03-01 00:00:00

  • Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

    abstract:BACKGROUND:The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters. METHODS:Nineteen obese ASA II patients undergoing bariatric surgery were studied. Patients received propofol 2 mg kg(-1) bolus dose followed by a 5-20-40-120 min, 10-8-...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aeq195

    authors: Cortínez LI,Anderson BJ,Penna A,Olivares L,Muñoz HR,Holford NH,Struys MM,Sepulveda P

    更新日期:2010-10-01 00:00:00

  • Effects of midazolam on insulin secretion from isolated rat pancreatic islets of Langerhans.

    abstract::Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenaline 10 mumol litre-1 was used as a control. In contrast with noradrenaline...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.2.221

    authors: Desborough JP,Jones PM,Persaud SJ,Howell SL

    更新日期:1993-02-01 00:00:00

  • Use of a mechanical simulator for training in applying cricoid pressure.

    abstract::Using an airway management training model, we have assessed anaesthesia personnel in their use of correct cricoid force and ability to retain this skill after a short training programme. A perspex device, working on a hydraulic principle, was used to measure cricoid pressure when applied to the model. After initial as...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/77.4.468

    authors: Ashurst N,Rout CC,Rocke DA,Gouws E

    更新日期:1996-10-01 00:00:00

  • Comparative haemodynamic effects of tubocurarine and metocurine in the dog.

    abstract::On accout of its histamine releasing and ganglion blocking properties tubocurarine is known to have significant haemodynamic effects. Methylation of the compound produces metocurine and should decrease both histamine release and ganglionic blockade. The haemodynamic effects of these two compounds were compared in 10 m...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.11.1007

    authors: Antonio RP,Philbin DM,Savarese JJ

    更新日期:1979-11-01 00:00:00

  • A dose-response study with nalbuphine hydrochloride for pain in patients after upper abdominal surgery.

    abstract::Six male patients were studied on the morning following upper abdominal surgery for highly selective vagotomy. Nalbuphine hydrochloride was infused i.v. at different rates that increased progressively in each hour over a 4-h period. In the last 15 min of each hour, the plasma nalbuphine concentrations were almost stea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.11.1356

    authors: Pugh GC,Drummond GB

    更新日期:1987-11-01 00:00:00

  • Anaesthesia for surgery in a patient with a transplanted heart.

    abstract::Five-year survival following cardiac transplantation approaches 50% and such patients occasionally present for non-cardiac surgery. The application of a simple general anaesthetic technique is described in a patient undergoing minor surgery, and the problems involved in managing heart transplant recipients are discuss...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.6.634

    authors: Bricker SR,Sugden JC

    更新日期:1985-06-01 00:00:00

  • Inhalation induction with sevoflurane: a double-blind comparison with propofol.

    abstract::We conducted a randomized, double-blind comparison of 8% sevoflurane and propofol as induction agents for day-case cystoscopy in 102 patients. All patients received an i.v. cannula and breathed oxygen 5 litre min-1. Anaesthesia was induced with propofol i.v. or inhalation of 8% sevoflurane and 10% Intralipid (as a pla...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/78.4.356

    authors: Thwaites A,Edmends S,Smith I

    更新日期:1997-04-01 00:00:00

  • The fibreoptic laryngoscope in the management of cut throat injuries.

    abstract::The trachea of a man who had cut his own throat was successfully intubated using a fibreoptic laryngoscope after attempts at conventional oral intubation had failed. The advantages of the fibreoptic instrument and the method of use in such an injury are discussed. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.5.511

    authors: Davies JR

    更新日期:1978-05-01 00:00:00

  • Use of di-isopropyl phenol as main agent for short procedures.

    abstract::The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with a...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/53.11.1197

    authors: Briggs LP,Clarke RS,Dundee JW,Moore J,Bahar M,Wright PJ

    更新日期:1981-11-01 00:00:00

  • A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man.

    abstract::The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in thre...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.4.345

    authors: Agoston S,Vermeer GA,Kersten UW,Scaf AH

    更新日期:1978-04-01 00:00:00

  • Effects of small concentrations of isoflurane on some psychometric measurements.

    abstract::We have investigated the effects of 9.5% and 14.1% MAC concentrations of isoflurane on some psychometric measurements. Both concentrations depressed peak saccadic velocity (P < 0.01), choice reaction time (P < 0.05) and visual analogue scores for sedation (P < 0.05), but not the critical flicker fusion threshold. The ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/71.6.839

    authors: Yoshizumi J,Marshall RW,Sanders LD,Vickers MD

    更新日期:1993-12-01 00:00:00

  • Determinants of outcome in critically ill octogenarians after surgery: an observational study.

    abstract:BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aem307

    authors: Ford PN,Thomas I,Cook TM,Whitley E,Peden CJ

    更新日期:2007-12-01 00:00:00

  • Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.

    abstract:BACKGROUND:Low fibrinogen (Fg) concentrations in trauma haemorrhage are associated with poorer outcomes. Cryoprecipitate is the standard source for Fg administration in the UK and USA and is often given in the later stages of transfusion therapy. It is not known whether early cryoprecipitate therapy improves clinical o...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev134

    authors: Curry N,Rourke C,Davenport R,Beer S,Pankhurst L,Deary A,Thomas H,Llewelyn C,Green L,Doughty H,Nordmann G,Brohi K,Stanworth S

    更新日期:2015-07-01 00:00:00

  • Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs.

    abstract::The effects of laudanosine, a metabolite of atracurium, on the behaviour of conscious mice, rats and dogs, and on cardiovascular function in conscious and anaesthetized dogs have been evaluated: EEG studies were performed in anaesthetized dogs. In mice and rats, i.v. bolus doses of laudanosine 10-20 mg kg-1, caused co...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.2.218

    authors: Chapple DJ,Miller AA,Ward JB,Wheatley PL

    更新日期:1987-02-01 00:00:00

  • The skeletal muscle response to edrophonium during neuromuscular blockade by tubocurarine in anaesthetized man.

    abstract::Tetanic contractions of the adductor pollicis muscle in man were evaluated continuously after the administration of tubocurarine 0.2 mg/kg and during reversal by edrophonium 0.1 mg/kg. Single twitch contractions of the adductor pollicis were measured simultaneously. The response of tetanic and single twitch contractio...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/47.10.1087

    authors: Sugai N,Payne JP

    更新日期:1975-10-01 00:00:00

  • Psychology of pain.

    abstract::This article briefly reviews psychological aspects of pain, paying special attention to chronic pain. The review considers the interruptive and interference effects of pain and its impact on a person's identity. The importance of processes related to interruption, interference, and identity will vary across people and...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aen123

    authors: Morley S

    更新日期:2008-07-01 00:00:00

  • Intelligent dynamic clinical checklists improved checklist compliance in the intensive care unit.

    abstract:Background:Checklists can reduce medical errors. However, the effectiveness of checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual patient. Our purpose in this simulation-base...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aex129

    authors: De Bie AJR,Nan S,Vermeulen LRE,Van Gorp PME,Bouwman RA,Bindels AJGH,Korsten HHM

    更新日期:2017-08-01 00:00:00

  • Effects of resuscitation fluids on T cell immune responses.

    abstract::This study was designed to determine whether dextran, gelatin or hydroxyethyl starch-based colloidal resuscitation fluids (CRF) are inhibitory to T lymphocyte activation and mitogenesis in vitro. Isolated peripheral blood lymphocytes from normal donors were activated with mitogen (PHA) and cultured in up to 50% v:v CR...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/81.2.242

    authors: Sillett HK,Whicher JT,Trejdosiewicz LK

    更新日期:1998-08-01 00:00:00

  • Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children. Effect on the pain associated with venous cannulation.

    abstract::The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner. Sixty boys and girls between the ages of 4 and 10 yr who were to undergo surgery participated in the study. No analgesic premedication was given and the venous cannulatio...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/58.11.1242

    authors: Maunuksela EL,Korpela R

    更新日期:1986-11-01 00:00:00

  • End-expiratory occlusion manoeuvre does not accurately predict fluid responsiveness in the operating theatre.

    abstract:BACKGROUND:The objective of this study was to determine whether assessment of stroke volume (SV) and measurement of exhaled end-tidal carbon dioxide [Formula: see text] during an end-expiratory occlusion (EEO) test can predict fluid responsiveness in the operating theatre. METHODS:Forty-two subjects monitored by oesop...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aet582

    authors: Guinot PG,Godart J,de Broca B,Bernard E,Lorne E,Dupont H

    更新日期:2014-06-01 00:00:00

  • Pharmacokinetics of glycopyrronium in uraemic patients.

    abstract::We studied the pharmacokinetics of glycopyrronium in 11 uraemic patients undergoing cadaveric renal transplantation and in seven ASA I control patients undergoing general surgery. Glycopyrronium 4 micrograms kg-1 was given i.v. before induction of anaesthesia. Blood and urine samples were collected for up to 24 h for ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/71.3.437

    authors: Kirvelä M,Ali-Melkkilä T,Kaila T,Iisalo E,Lindgren L

    更新日期:1993-09-01 00:00:00

  • Comparison of propofol/remifentanil and sevoflurane/remifentanil for maintenance of anaesthesia for elective intracranial surgery.

    abstract:BACKGROUND:Propofol and sevoflurane are suitable agents for maintenance of anaesthesia during neurosurgical procedures. We have prospectively compared these agents in combination with the short-acting opioid, remifentanil. METHODS:Fifty unpremedicated patients undergoing elective craniotomy received remifentanil 1 mic...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/aei141

    authors: Sneyd JR,Andrews CJ,Tsubokawa T

    更新日期:2005-06-01 00:00:00

  • Days alive and out of hospital after fast-track total hip and knee arthroplasty: an observational cohort study in 16 137 patients.

    abstract:BACKGROUND:Days alive and out of hospital (DAH) has been proposed as a pragmatic outcome measure of surgical quality. However, there is a lack of procedure specific data or data within an optimised fast-track protocol. Furthermore, information about influence of follow-up duration and types of complications on DAH is l...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.bja.2019.07.022

    authors: Jørgensen CC,Petersen PB,Kehlet H,Lundbeck Foundation Center for Fast-track Hip and Knee Replacement Collaborative Group.

    更新日期:2019-11-01 00:00:00

  • Uncalibrated arterial pressure waveform analysis for cardiac output monitoring is biased by low peripheral resistance in patients with intracranial haemorrhage.

    abstract:BACKGROUND:Cardiac output (CO) monitoring by uncalibrated arterial pressure waveform analysis (APCO) using the FloTrac/Vigileo™ is feasible in patients with intracranial haemorrhage, but the results of validation studies are contradictory. The aim of the present study was to analyse the clinical agreement between the i...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer170

    authors: Junttila EK,Koskenkari JK,Ohtonen PP,Ala-Kokko TI

    更新日期:2011-10-01 00:00:00

  • Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat.

    abstract::We have studied the effect of clonidine, dexmedetomidine and morphine on gastric emptying and gastrointestinal transit in the rat. In one group, each agonist was injected i.p. in 6-12 male Wistar rats. In another group of rats, yohimbine, naloxone or saline was injected with an agonist. At 30 min, radiolabelled saline...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/78.3.301

    authors: Asai T,Mapleson WW,Power I

    更新日期:1997-03-01 00:00:00

  • Diagnostic and management dilemmas in a patient with tracheal trauma.

    abstract::A patient with a foreign body penetrating the neck and chest was found to have physical signs which were consistent with serious tracheal injury and included a large movement of air through the lower part of the neck. The subsequent management of the patient and the difficult problem of securing an airway are describe...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/66.6.724

    authors: Brierley JK,Oates J,Bogod DG

    更新日期:1991-06-01 00:00:00