A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

Abstract:

:The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy volunteers. No significant change in the ventilatory response to rebreathing carbon dioxide was observed after meptazinol 100 mg/70 kg or placebo. However, both morphine 10 mg/70 kg and pentazocine 60 mg/70 kg depresesd the slope of the ventilatory response (-30.0% and -31.6% respectively, P less than 0.02, averaged over the first 3.5-h period). End-tidal carbon dioxide tension (PE'CO2) while breathing room air increased significantly following all three drugs. However, the increase in PE'CO2 after meptazinol (0.22 kPa averaged over 3.5 h) was significantly less than that following morphine (0.40 kPa, P less than 0.05) and pentazocine (0.59 kPa, P less than 0.01). While breathing room air with a resistive inspiratory load of 8 kPa litre-1 s, PE'CO2 again increased significantly (P less than 0.05) following all three drugs. The increase in PE'CO2 after meptazinol was then the same as that after morphine (0.51 kPa averaged over 3.5 h). The increase following pentazocine (0.80 kPa) was significantly greater than that after both morphine and meptazinol (P less than 0.02).

journal_name

Br J Anaesth

authors

Jordan C,Lehane JR,Robson PJ,Jones JG

doi

10.1093/bja/51.6.497

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

497-502

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)44926-9

journal_volume

51

pub_type

临床试验,杂志文章,随机对照试验
  • Interactions between the neuromuscular blocking drug Org NC 45 and some anaesthetic, analgesic and antimicrobial agents.

    abstract::The effects of some anaesthetics and other agents used in anaesthetic practice on the neuromuscular blocking activity of cumulative doses of Org NC 45 have been studied in cats anaesthetized with chloralose. As expected from studies with other neuromuscular blocking drugs, both inhalation and i.v. anaesthetics reduced...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.8.785

    authors: McIndewar IC,Marshall RJ

    更新日期:1981-08-01 00:00:00

  • Effect of baricity on spinal anaesthesia with amethocaine.

    abstract::Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/52.6.589

    authors: Brown DT,Wildsmith JA,Covino BG,Scott DB

    更新日期:1980-06-01 00:00:00

  • Gram stain of bronchoalveolar lavage fluid in the early diagnosis of ventilator-associated pneumonia.

    abstract::To assess the usefulness of the Gram stain in the early diagnosis of ventilator-associated pneumonia (VAP), we performed 146 protected specimen brushings (PSB) and bronchoalveolar lavages (BAL) in 118 patients suspected of having nosocomial pneumonia. Gram stain and counts of infected cells were performed in all sampl...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/83.6.845

    authors: Allaouchiche B,Jaumain H,Chassard D,Boulétreau P

    更新日期:1999-12-01 00:00:00

  • Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat.

    abstract::We have studied the effect of clonidine, dexmedetomidine and morphine on gastric emptying and gastrointestinal transit in the rat. In one group, each agonist was injected i.p. in 6-12 male Wistar rats. In another group of rats, yohimbine, naloxone or saline was injected with an agonist. At 30 min, radiolabelled saline...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/78.3.301

    authors: Asai T,Mapleson WW,Power I

    更新日期:1997-03-01 00:00:00

  • Protective ventilation of patients with acute respiratory distress syndrome.

    abstract::The majority of patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation. This support provides time for the lungs to heal, but the adverse effects of mechanical ventilation significantly influence patient outcome. Traditionally, these were ascribed to mechanical effects, such as haemody...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aeh031

    authors: Moloney ED,Griffiths MJ

    更新日期:2004-02-01 00:00:00

  • Isolated lung transplantation: a review of problems and guide to anaesthesia.

    abstract::Some recipients of isolated, orthotopic lung transplants have now survived to leave hospital with greatly improved quality of life. Inevitably, the successful demonstration of the feasibility of these operations means that transplant centres throughout the world may wish to participate in a lung transplant programme. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/61.4.468

    authors: Conacher ID

    更新日期:1988-10-01 00:00:00

  • Effects of temperature and haematocrit on the relationships between blood flow velocity and blood flow in a vessel of fixed diameter.

    abstract:BACKGROUND:To determine whether temperature and haematocrit (Hct) alter the relationship between blood flow (BF) and blood flow velocity (BFV). METHODS:Using a transcranial Doppler apparatus, we measured the peak velocity of whole blood cells pumped by a cardiopulmonary bypass (CPB) circuit, through a 0.15-cm internal...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/88.2.277

    authors: Paut O,Bissonnette B

    更新日期:2002-02-01 00:00:00

  • The auditory steady state response during sufentanil anaesthesia.

    abstract::The auditory steady state response (ASSR) is a sinusoidal evoked potential elicited by rapidly repeated auditory stimuli. The ASSR was recorded in eight patients during high-dose sufentanil anaesthesia for cardiac surgery in order to assess its usefulness as a measure of the level of consciousness. The electroencephal...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/66.6.683

    authors: Plourde G,Boylan JF

    更新日期:1991-06-01 00:00:00

  • Randomized cross-over comparison of cervical-spine motion with the AirWay Scope or Macintosh laryngoscope with in-line stabilization: a video-fluoroscopic study.

    abstract:BACKGROUND:The AirWay Scope (AWS) is a fibreoptic device that allows for intubation without alignment of the oral, pharyngeal, and tracheal axes. It may be useful for patients with an unstable cervical-spine (C-spine) or when C-spine movement is undesirable. This study was conducted to fluoroscopically evaluate upper C...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aen207

    authors: Maruyama K,Yamada T,Kawakami R,Hara K

    更新日期:2008-10-01 00:00:00

  • Effects of amrinone on left and right ventricular function in patients with impaired myocardial performance during general anaesthesia.

    abstract::We have studied the effects of amrinone on left and right ventricular haemodynamics in patients with impaired ventricular performance caused by coronary artery disease. Anaesthesia was achieved with fentanyl, flunitrazepam and pancuronium. After reaching steady state, a bolus dose of amrinone 0.5 mg kg-1 was administe...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/72.5.567

    authors: Petry A,Dütschke P

    更新日期:1994-05-01 00:00:00

  • Printed three-dimensional airway model assists planning of single-lung ventilation in a small child.

    abstract:BACKGROUND:Single-lung ventilation in infants and small children is challenging because suitable sizes of double-lumen cuffed tracheal tubes are not available. A 6-yr-old child required pulmonary saline washout for primary alveolar proteinosis, and therefore needed sequential single-lung ventilation in order to achieve...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aev305

    authors: Wilson CA,Arthurs OJ,Black AE,Schievano S,Hunt C,van Hoog S,Wallis C,Sury MR

    更新日期:2015-10-01 00:00:00

  • Mitochondrial redox state in the critically ill.

    abstract::Abnormal oxygen use and organ failure in the critically ill may result from 'poisoning' of mitochondrial function. Measurement of arterial ketone body ratio (AKBR) has been proposed to reflect mitochondrial redox state and may provide a useful marker to monitor mitochondrial function in the critically ill. We measured...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/83.2.325

    authors: Yassen KA,Galley HF,Lee A,Webster NR

    更新日期:1999-08-01 00:00:00

  • Comparison of duration of neuromuscular blocking effect of atracurium and vecuronium in young and elderly patients.

    abstract::In a controlled, randomized study, we evaluated duration of neuromuscular block in 80 patients undergoing routine abdominal surgery. Forty patients were aged 18-50 yr (control group) and 40 patients were more than 65 yr (elderly group). All patients had normal plasma creatinine concentrations. After induction of anaes...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/74.6.709

    authors: Slavov V,Khalil M,Merle JC,Agostini MM,Ruggier R,Duvaldestin P

    更新日期:1995-06-01 00:00:00

  • Correlation of microalbuminuria and outcome in patients with extensive burns.

    abstract:BACKGROUND:Microalbuminuria, often referred to as the urinary albumin-creatinine ratio (ACR), is thought to be a reflection of increased capillary permeability associated with the systemic inflammatory response syndrome, and has been found to be predictive of outcome in several studies. Therefore, we explored the usefu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael211

    authors: Yew WS,Pal SK

    更新日期:2006-10-01 00:00:00

  • Study to determine the repeatability of supra-sternal Doppler (ultrasound cardiac output monitor) during general anaesthesia: effects of scan quality, flow volume, and increasing age.

    abstract:BACKGROUND:The ultrasound cardiac output monitor (USCOM) is a continuous wave Doppler system designed to measure cardiac output (CO) non-invasively and intermittently either from the pulmonary or from the aortic valve. USCOM scan quality is critical to obtaining reliable data and during anaesthesia it is said to deteri...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aet254

    authors: Huang L,Critchley LA

    更新日期:2013-12-01 00:00:00

  • Comparison of sampling techniques for studies of nitrous oxide pollution.

    abstract::The retention of nitrous oxide in samples of nitrous oxide in air held in disposable plastic syringes, glass syringes and custom-made nylon film bags was studied by means of gas chromatography at intervals of 90 min, 24, 48 and 120 h after filling the containers. After 24 h the nylon bags retained a mean concentration...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.11.1109

    authors: Austin JC,Shaw R,Crichton R,Cleaton-Jones PE,Moyes D

    更新日期:1978-11-01 00:00:00

  • Review of perioperative falls.

    abstract::Falls are a known public health problem, and there is increasing recognition of the importance of perioperative falls for risk prediction and quality assessment. Our objective was to review existing literature regarding the occurrence, injuries, and risk factors of preoperative and postoperative falls. A systematized ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aew377

    authors: Kronzer VL,Wildes TM,Stark SL,Avidan MS

    更新日期:2016-12-01 00:00:00

  • Diazepam: routes of administration and rate of absorption. A study of women with pre-eclampsia.

    abstract::Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/48.11.1091

    authors: Sturdee DW

    更新日期:1976-11-01 00:00:00

  • Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.

    abstract:BACKGROUND:We used an automated bispectral index (BIS)-guided dual-loop controller to determine propofol and remifentanil requirements during general anaesthesia in obese and lean surgical patients. METHODS:Obese patients, BMI>35 kg m(-2), and lean patients (<25 kg m(-2)) having laparoscopic procedures were prospectiv...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/bja/aeu401

    authors: Liu N,Lory C,Assenzo V,Cocard V,Chazot T,Le Guen M,Sessler DI,Journois D,Fischler M

    更新日期:2015-04-01 00:00:00

  • Effect of clonidine on gastric emptying of liquids.

    abstract::We have investigated the effects of clonidine on gastric emptying of liquids in 30 patients. In a double-blind, randomized design, clonidine 150 micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later, the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous blood samples were obtaine...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/78.1.28

    authors: Asai T,McBeth C,Stewart JI,Williams J,Vaughan RS,Power I

    更新日期:1997-01-01 00:00:00

  • Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability.

    abstract::In a double-blind, placebo-controlled three-way cross over study, the efficacy of Ro 15-1788 200 mg, a new benzodiazepine antagonist, in blocking the amnesic, cognitive, psychomotor and subjective effects of diazepam 20 mg, was investigated in a group of six healthy male volunteers. The amnesic effects of diazepam wer...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/55.4.349

    authors: O'Boyle C,Lambe R,Darragh A,Taffe W,Brick I,Kenny M

    更新日期:1983-04-01 00:00:00

  • Premedication of children with trimeprazine tartrate.

    abstract::A double-blind trial was undertaken to compare the effects of trimeprazine tartrate (2 mg kg-1 or 4 mg kg-1) plus atropine 0.03 mg kg-1 for oral premedication of 192 children undergoing tonsillectomy. Demeanour before operation, side-effects after operation, recovery times and fluid balance were studied. Behaviour in ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/53.8.821

    authors: Bramwell RG,Manford ML

    更新日期:1981-08-01 00:00:00

  • Effect of lidocaine on ischaemic preconditioning in isolated rat heart.

    abstract:BACKGROUND:Lidocaine is frequently used as an agent to treat ventricular arrhythmias associated with acute myocardial ischaemia. Lidocaine is a potent blocker not only of sodium channels, but also of ATP-sensitive potassium channels. The opening of these channels is a key mechanism of ischaemic preconditioning. We inve...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeh262

    authors: Barthel H,Ebel D,Müllenheim J,Obal D,Preckel B,Schlack W

    更新日期:2004-11-01 00:00:00

  • Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. I: Patients premedicated with morphine sulphate.

    abstract::The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaesthesia in 57 patients premedicated with morphine sulphate 0.15 mg kg-1. Anaesthesia was induced with propofol 2 mg kg-1, and maintained before incision with a fixed-rate...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/58.10.1080

    authors: Spelina KR,Coates DP,Monk CR,Prys-Roberts C,Norley I,Turtle MJ

    更新日期:1986-10-01 00:00:00

  • Bispectral Index asymmetry and COMFORT score in paediatric intensive care patients.

    abstract:BACKGROUND:The Bispectral Index (BIS) monitor has been suggested as a potential tool to measure depth of sedation in paediatric intensive care unit (PICU) patients. The primary aim of our observational study was to assess the difference in BIS values between the left and right sides of the brain. Secondary aims were to...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aen035

    authors: Froom SR,Malan CA,Mecklenburgh JS,Price M,Chawathe MS,Hall JE,Goodwin N

    更新日期:2008-05-01 00:00:00

  • Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints.

    abstract:BACKGROUND:State entropy (SE) is a newly available monitor for depth of anaesthesia. We investigated whether the relationship between predicted effect-site propofol concentration and Bispectral Index (BIS) and SE values is useful for predicting loss of verbal contact and loss of consciousness during steady-state condit...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei075

    authors: Iannuzzi M,Iannuzzi E,Rossi F,Berrino L,Chiefari M

    更新日期:2005-04-01 00:00:00

  • Use of prothrombin complex concentrate for management of coagulopathy after cardiac surgery: a propensity score matched comparison to plasma.

    abstract:BACKGROUND:An important cause of coagulopathy in cardiac surgery is impaired thrombin generation. While plasma is often used to correct this element of the coagulopathy, studies in vitro suggest that prothrombin complex concentrates (PCCs) might be more effective. Comparative data, however, are scant. METHODS:We compa...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.02.017

    authors: Fitzgerald J,Lenihan M,Callum J,McCluskey SA,Srinivas C,van Rensburg A,Karkouti K

    更新日期:2018-05-01 00:00:00

  • Magnesium moderately decreases remifentanil dosage required for pain management after cardiac surgery.

    abstract:BACKGROUND:Magnesium is a calcium and an NMDA-receptor antagonist and can modify important mechanisms of nociception. We evaluated the co-analgesic effect of magnesium in the postoperative setting after on-pump cardiac surgery. METHODS:Forty patients randomly received either magnesium gluconate as an i.v. bolus of 0.2...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/ael037

    authors: Steinlechner B,Dworschak M,Birkenberg B,Grubhofer G,Weigl M,Schiferer A,Lang T,Rajek A

    更新日期:2006-04-01 00:00:00

  • Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery.

    abstract::We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/81.5.707

    authors: Ilkjaer S,Nikolajsen L,Hansen TM,Wernberg M,Brennum J,Dahl JB

    更新日期:1998-11-01 00:00:00

  • Effect of graft reperfusion on haemodynamics and gas exchange during liver transplantation.

    abstract::We have documented the changes in gas exchange, haemodynamic state and associated physiological variables which occurred after graft reperfusion in 20 patients undergoing uncomplicated orthotopic liver transplantation. Gas exchange was measured during constant ventilation using a metabolic monitor. After reperfusion, ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/81.3.311

    authors: Walsh TS,Hopton P,Garden OJ,Lee A

    更新日期:1998-09-01 00:00:00