Abstract：
BACKGROUND:Lidocaine is frequently used as an agent to treat ventricular arrhythmias associated with acute myocardial ischaemia. Lidocaine is a potent blocker not only of sodium channels, but also of ATP-sensitive potassium channels. The opening of these channels is a key mechanism of ischaemic preconditioning. We investigated the hypothesis that lidocaine blocks the cardioprotection induced by ischaemic preconditioning. METHODS:Isolated rat hearts (n=60) were subjected to 30 min of no-flow ischaemia and 60 min of reperfusion. Control hearts (CON) underwent no further intervention. Preconditioned hearts (PC) received two 5-min periods of ischaemia separated by 10 min of reflow before the 30 min ischaemia. In three groups, lidocaine was infused at concentrations of 2, 10 or 20 microg ml(-1) for 5 min before the preconditioning ischaemia. Left ventricular developed pressure (LVDP) and infarct size (IS) (triphenyltetrazolium choride staining) were measured as variables of ventricular function and cellular injury, respectively. RESULTS:PC reduced IS from 24.8 (sem 4.1) % to 4.0 (0.7) % of the area at risk (P<0.05). Adding 2 or 10 microg ml(-1) lidocaine had no effect on IS compared with PC alone (3.7 (0.7) %, 6.9 (1.8) %). Adding 20 microg ml(-1) lidocaine increased IS to 14.1 (2.5) % compared with PC (P<0.05). Baseline LVDP was similar in all groups (111.4 (2.1) mm Hg). Compared with CON, PC improved functional recovery (after 60 min of reperfusion; 52.3 (5.9) mm Hg vs 16.0 (4.0) mm Hg, P<0.01). The improved ventricular function was not influenced by addition of 2 or 10 microg ml(-1) lidocaine (47.3 (5.7) mm Hg, not significant; 45.3 (7.3) mm Hg, not significant), but was blocked by the infusion of 20 microg ml(-1) lidocaine (22.5 (8.0) mm Hg, P<0.01 vs PC). CONCLUSIONS:Lidocaine blocks the cardioprotection induced by ischaemic preconditioning only at supratherapeutic concentrations.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Barthel H,Ebel D,Müllenheim J,Obal D,Preckel B,Schlack Wdoi
10.1093/bja/aeh262subject
Has Abstractpub_date
2004-11-01 00:00:00pages
698-704issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)35824-5journal_volume
93pub_type
杂志文章abstract：:We have studied the haemodynamic and myocardial effects of propofol-fentanyl anaesthesia in 12 patients undergoing coronary artery bypass surgery during the pre-bypass period. The induction dose of propofol was 1.5 mg kg-1 and mean infusion rate during maintenance was 4.48 mg kg-1 h-1 (range 1.87-7.24 mg kg-1 h-1). Th...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/66.4.504
更新日期：1991-04-01 00:00:00
abstract：:All 484 candidates for the 1988 Fellowship in Anaesthesia (Part Three) were surveyed to investigate any differences between successful and unsuccessful candidates in study techniques, work and domestic factors, and examination history that might lead to better guidance to those preparing for the examination and an imp...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/64.6.752
更新日期：1990-06-01 00:00:00
abstract：:Riluzole modulates several transmitter systems which may be involved in nociception. Antinociceptive effects have been shown in animal studies, but there are no human data. Therefore, we have examined the acute analgesic effect of riluzole in a human model of inflammatory pain induced by a thermal injury on the distal...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/82.5.718
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Several medications have proved to be useful in preventing postoperative nausea and vomiting (PONV). However, routine antiemetic prophylaxis is not cost-effective. We evaluated the accuracy and discriminating power of an artificial neural network (ANN) to predict PONV. METHODS:We analysed data from 1086 in-...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael282
更新日期：2007-01-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/bja/83.4.564
更新日期：1999-10-01 00:00:00
abstract：:The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.1.22
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to determine whether assessment of stroke volume (SV) and measurement of exhaled end-tidal carbon dioxide [Formula: see text] during an end-expiratory occlusion (EEO) test can predict fluid responsiveness in the operating theatre. METHODS:Forty-two subjects monitored by oesop...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet582
更新日期：2014-06-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/57.2.220
更新日期：1985-02-01 00:00:00
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journal_title：British journal of anaesthesia
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更新日期：2018-05-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.10.1021
更新日期：1980-10-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.5.527
更新日期：1992-05-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.4.522
更新日期：1996-10-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.6.796
更新日期：1993-12-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/59.8.1017
更新日期：1987-08-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.6.758
更新日期：1996-12-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 杂志文章,多中心研究
doi：10.1093/bja/aev369
更新日期：2015-12-01 00:00:00
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journal_title：British journal of anaesthesia
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doi：10.1093/bja/aer386
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-05-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of anaesthesia
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1998-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/bja/aeq367
更新日期：2011-03-01 00:00:00
